1109
www.neurologiepropraxi.cz34080430107651332012142633073553814284484965465656086586857327828098518919109269661005
/33788043010732
Neurol.3455804301075593139165209227243
praxi.3714804301074672114152170186
2023;24(5):346-3523916804301074487128172186230270295337360374419463509538579621662
/46238043010732
NEUROLOGIE47018043010757101158205267310370429450493
PRO5216804301074591154
PRAXI5391804301074591148201221
35156558026012657113167
HLAVNÍ4945207012670127198263336370
TÉMA5337207012657114204274
Precizní411236501063368100135153185227244
neuroonkologie437236501063971111147187228270306345376415455472504
–4892365010645
realita495336501063365107138156188224
a5193365010638
perspektivy524636501063365100135169201236270288326365
LITERATURA341380001234978134189250318368438498567
1.34039600853648
Appay40939610834180120153184
R,61339610833549
Dehais68339610834580119151166192
C,89539610834053
Maurage96939610835487124145178217252
C‑A,12423961083405395109
Alentorn13713961083415791129151188210248
A,164039610834055
et171539610833456
al.17923961083314760
CDKN2A18723961083408512134040610834580123
homozygous48440610833877136176204239278317356383
deletion8884061083397591126149165204243
is115240610831541
a1214406108333
strong12684061083265072110149189
adverse147840610833272106141162190226
prognosis172540610833961100140179218245260287
factor3404161083185284108145167
in52541610831553
diffuse597416108338537291130156191
malignant80741610835790105120159197229267289
IDH‑mutant111441610831561106129187225248280318340
gliomas.14734161083385368106164197223237
Neuro172941620834373109130165
Oncol.190941620834582340426208329637892
2019;21:1519-28.44742620833468100130143178209218248278309339363394427441
2.34043600853652
Binabaj4054362083355189121160193208
MM,627436208354109123
Bahrami76343620833669107128161219234
A,101043620834155
ShahidSales107943620833270102140156194227260275310337
S,142943620833346
et148843620833456
al.15584362083314760
The163143620833372107
prognostic175143620833961981371762142413404461083223769
value4304461083326581118153
of60444610833757
MGMT68244610835499154188
promoter8914461083386098156195217251272
methylation118444610835893115154185201233255271309348
in155244610831553
glioblastoma:16264461083385469107147163195222246283341374386
A340456108340
meta‑analysis39345610835791113145167199236268283314340355380
of78545610833756
clinical853456108331466198113144176191
trials.1056456108322435889104130143
J1211456208324
Cell1245456208337668095
Physiol.13504562083336895120133168183196
2018;233:378-86.15564561083346798129141175209241252287318351373409443456
3.34046600853651
Brat4104661083355790111
DJ,5414661083456780
Aldape6404661083415695128167202
K,86246610833549
Colman9314661083407793150183221
H,117146610834457
et124746610833457
al.13234661083324760
cIMPACT‑NOW140346610833146101137174213249267313361419
update18414661083387711614934047610832255
5:41647610833445
recommended4814761083215588125183241276314354389428
grading9304761083385992131146184223
criteria1174476108331526890124145161193
and138747610833270109
terminologies15174761083225577135150188227243281320335370397
for19354761083185677
IDH‑mutant34048610831560104126184221244276313334
astrocytomas.6874861083315780101138170203228264321353379393
Acta10924862083376688122
Neuropathol.122448620834272108128162198234254290325340353
2020;139:603-8.159048610833467100133146176205238251285320353374410423
4.34049600853651
Buckner40449610833573105135174209231
JC,6484961083246578
Shaw73949610833270102153
EG,9054961083327690
Pugh100849610833572111149
SL,11704961083326377
et126049610833456
al.13294961083324760
Radiation140249610833568107122154176191229267
plus16824961083395592118
Procarbazine,1814496108335559212515817934050610833972101117155190202
CCNU,55550610834078123167178
and74750610833270109
Vincristine8695061083365290122144159185209224262297
in117950610831553
Low‑Grade124550610833269120142189211244283318
Glioma.15765061083446075113171203217
N1806506208343
Engl186050620833167102117
J1988506208324
Med.34051620835383119133
2016;374:1344-55.48851620833468100131143179211241253283313348385408442475487
5.34052600853650
Cairncross4085262083407388109148180201238265292
G,71752620834357
Wang79152620835789127166
M,97452620835468
Shaw105952620833270103153
E,122952620833346
et129252620833457
al.13665262083314760
Phase144352620833572105131166
III16265262083153046
trial1689526208321435991106
of181252620833757
chemoradiotherapy18865262083316910434053610835693114146184198235256293327347379417447
for7995361083185475
anaplastic8865361083316899137152183209231246277
oligodendroglioma:11745361083375266104141179213250288308344382397411448505536547
long‑term17335361083155289127148170202223279
results3405461083215582119134156184
of54054610833756
RTOG61154610833670116161
9402.78754610833570106139928546008515
J955546208324
Clin9925462083375267103
Oncol.110854620834582112146161174
2013;31:337-43.129554610833468100130141176207216251284316335371404416
6.34055600853652
Doroshow41155620834584106143169207246297
DB,7275562083468295
Doroshow84155620834684106143170208246297
JH.11585562083246982
Genomics126055620834379117155214229261288
and156855620833270109
the16975562083215994
History18115562083445986109146167201
of34056620833757
Precision4125662083355690122138164178216255
Oncology.68256620834786118155171209249281962566008515
Surg9895662083316686121
Oncol112256620834583112147162
Clin12965662083385367104
N1412566208343
Am.1468566208337931561566208312
2020;29:35-49.158956620833468101135148183217230265298320357390401
7.34057600853644
Doz39757610834583111
F,52157610833238
van57157610833264102
Tilburg6865761083324964102140161199
CM,89757610834095108
Geoerger101857610834378117152173211245266
B,129757610833547
et135757610833456
al.14255761083324760
Efficacy1497576108333506886118150182215
and172557610833169108
safety18455761083265978112134167
of34058610833755
larotrectinib4075861083154667103124145178210234248285300338
in75758610831451
TRK82158610833268103
fusion‑positive936586108318568195132170192231269295309331345377410
primary13595861083385873130161182215
central158658610833164101122143175190
nervous17885861083377191125162199225
system3405961083265986109143200
tumors.55659610832159117156177204218
Neuro79059620834373109130165
Oncol.96759620834583112146162175
2022;24:997-1007.115459610833468101136148183215227262298330349380411447480486
8.34060600853652
Ducray40860620834584116137170201
F,62560620833238
Sanson67960620833366104130168207
M,90260620835468
Chinot9866062083407792130169190
O,119360620834658
et126760620833456
al.13396062083324760
KS02.141560620833570105138150
4.158160620833447
A1644606208341
Olaparib17016062083476395134167188204243
in196060620831553
Recurrent34061620833570103141162184218256277
IDH‑mutant63661620831561106128187225247280318340
High‑Grade9946162083446098136159205227260299334
Glioma13476162083435974112170203
(OLAGLI).15696162083186497140183215230249260
Neuro184861620834373109130165
Oncol.34062620834582112146161175
2021;23:ii4.53062620833468101133141176211222237252287300
9.34063600853649
Federici41063610833266106141162178210225
L,65663610833145
Capelle72163610834073112148164179214
L,95563610833245
Annereau102163610834179117152173208239277
M,131963610835468
et140763610833456
al.14846361083324760
5-Azacitidine15656361083345697128162194209232247286301339374
in196063610831452
patients3406461083397395111146185207235
with5966461083516790129
IDH1/2-mutant74664610831561107139161197218277316339372411433
recurrent12006461083215589127149171206244266
glioma.14876461083395570109168201214
Neuro172364620834374111132167
Oncol.190864620834583340656208329637892
2020;22:1226-8.44765610833468101135148183218230260290325358382418431
10.3406660085367085
Gonzalez43866610834482121150183199233263
Castro7146661083407399122144181
LN,9086661083317689
Wesseling101066610835791117144179194209247286
P.130966610833540
The136266610833372107
cIMPACT‑NOW148266610833146101137174213249267313361418
updates1913666108338773406761083387091125151
and50467610833169107
their6246761083225994109130
significance7666761083264179117132149166198230268300333
to111167610832258
current11826761083316989111144182203
neuro‑oncology139867610833772109130167190229267299335351389428459
practice.187067610833860921243406861083223769103115
Neurooncol47068620834373109130165201238267302317
Pract.7996862083345387117139152
2021;8:4-10.96368610833468101133141176188223246277308321
11.3406960085356476
Kaley4286961083346782115146
T,58669610833240
Touat63869610833265102134155
M,80569610835366
Subbiah88369610833268106145160191228
V,112369610833543
et117869610833355
al.12456961083314658
BRAF131569610833570112143
Inhibition14706961083155289103141156178192229267
in174969610831451
BRAFV600-Mutant18126961083357011114318034070610833571108133191229253287326348
Gliomas:7097061083456177116176209236249
Results9807061083367299138154177205
From12077061083335391151
the13797061083226298
VE‑BASKET14987061083367194132174209244280316
Study.18357061083335594134167177
J340716208324
Clin3777162083375267103
Oncol.49371620834582112146161174
2018;36:3477-84.68071610833468100131143178213225260296328362381417453466
12.3407260085366985
Lassman4467261083326693120179212251
AB,7187261083417891
Sepúlveda‑Sánchez83072610833369108147163196231272305328360393432465504539569
JM,14207261083258195
et153672610833457
al.16147261083324861
Infigratinib1696726108315547289129151184206222261276316
in34073610831554
Patients4157361083366991107142182204232
with6687361083526891130
Recurrent82073610833672105144166188223262284
Gliomas11267361083446176115175208235
and138373610833271111
FGFR151573610833378112148
Alterations:16847361083425881116138172194210249288316328
A340746108341
Multicenter39674610835593108130146178211249271305326
Phase73774610833573105132167
II91974610831530
Study.9647461083335492131163173
Clin11497462083385267103
Cancer126574620833873109139168188
Res.14667462083346489103
2022;28:2270-7.158574610833468101136148183217229264299332365389420426
13.3407560085366883
Loriot4397562083316990106144166
Y,62175620833543
Schuler68075620833365103141156191212
MH,90875620835599112
Iyer10367562083154781102
G,115575620834357
et122875620833456
al.13007562083324760
Tumor137675620833366124163184
agnostic157675620833271109147174197213244
efficacy183775620833452708812015334076620833165
and42376620833270109
safety5517662083265978113135169
of73876620833857
erdafitinib8147662083345593125143160182198236251290
in112276620831553
patients11947662083387193108143181203230
(pts)14437662083195880108125
with15877662083516689127
advanced173376620833170103136174206240279
solid340776208326648095134
tumors49377620832159117156177204
with7167762083516689127
prespecified8627762083386094121160195228243261278312352
fibroblast1233776208317347394131171187219246269
growth15207762083386097148173211
factor17497762083195284108145167
receptor193577620832054214039620833165104126163185
alterations23413962083324770103125158179195233271297
(FGFRalt)26553962083185195128163196211234252
in292439620831452
RAGNAR:299339620833578121166208243257
Interim32663962083155374108129145203
analysis348539620833270102118149176191217
(IA)3719396208318337493
results.21404062083215582119134156184198
JCO.235340620832462106118
2022;40:3007-3007.248440620833468101136148183219232267302338370389421456492525531
14.21404160085366984
Louis224141620833169107122148
DN,240641620834591104
Perry25274162083356890111145
A,268941620834155
Reifenberger27614162083367186105139178217252274312347368
G,314641620834357
et322041620833456
al.32934162083324760
The337041620833372107
2016349441620833468100131
World364241620835794115131170
Health214042620834479111126149187
Organization234542620834769107139177192221255277292330368
Classification27324262083395587113140155172189222254276291329368
of311842620833757
Tumors319342620833266123162183211
of342242620833756
the34964262083226095
Central360942620834074112134155188204
Nervous214043610834579100135172210236
System:23894361083326289112145203215
a2617436108332
summary.266143610832664121179211232266275
Acta29474362083376789123
Neuropathol.308043620834373109129164200236257293328343356
2016;131:80320.34474361083346810013014317320223324127631134421404461083346881
15.21404560085366782
Louis223445610833168105120146
DN,239245610834590103
Perry25074561083356889110144
A,266345610834154
Wesseling273045610835789116142176192206244282
P,302545610833439
et307645610833456
al.31444561083324759
The321645610833271105
202133344561083336799130
WHO3477456108357101149
Classification363845610834054861121381532140466108317346699121136174212
of236546610833857
Tumors243546610833366124162184211
of265946610833857
the27294661083226095
Central283746610834074112133155188203
Nervous305346610834580101136174212238
System:33044661083336289113146204216
a3534466108331
summary.35784661083276412217921221404762083215565
Neuro221747620834373109130165
Oncol.239447620834583112146162175
2021;23:1231-51.258247620833468101133141176211222252282316347366400431440
16.21404860085367086
Machida224748610835588120159174213246
Y,251348610833644
Nakagawa257848610834578108142181214265298
M,289748610835568
Matsunaga298648610835588110138175214246286318
H,332548610834457
et340348610833457
al.34814861083324760
A3562486108341
Potent36244861083357294129167189
Blood‑Brain21404961083355087125163185221242274288325
Barrier‑Permeable24774961083356787109124157178197233265286343377408446462495
Mutant298449610835491113145182202
IDH1319949610831459103133
Inhibitor33444961083155289103142156178214235
Suppresses35914961083326810714516619921405061083275591119
the22815061083236299
Growth240250610834567106159185225
of264950610833859
Glioblastoma27295061083456278118159176210237262300361394
with31455061083526993132
IDH1329950610831563110143
Mutation346450610835695119153176192232272
in375850610831554
a2140516108332
Patient‑Derived21905161083356789104139177199218265301322338370404444
Orthotopic26535161083476893131169191228268283315
Xenograft298751610833871109148187208241260285
Model.329151610835493132167183196
Mol350551620835389104
Cancer362451620833873109139168188
Ther.21405262083316898119130
2020;19:375-83.228552620833468101135148178208221257289322344379413426
17.21405360085366876
Mellinghoff223253620835490105120135173212250288308327
IK,25755362083145064
Ellingson2655536208333486378116155181219257
BM,292853620833590104
Touat304753620833367105137159
M,322153620835568
et330553620833456
al.33775362083314760
Ivosidenib34525362083154785112127165200238253293
in376053620831553
Isocitrate21405461083154281114129152174208230265
Dehydrogenase242654610834682121152191213251291326365398425461
1-Mutated290854610833554111149172206228262303
Advanced323254610834180114147186219253293
Glioma.35465461083456176115174207221
J3788546208324
Clin21405562083385267103
Oncol.225655620834583112146161175
2020;38:3398-406.244355610833468101135148183218230265298331366389426461497510
18.21405660085366985
Mellinghoff224056620835490105120135173212250288308327
IK,25825662083155065
Penas‑Prado266256620833568107139165186223244277316354
M,303156620835568
Peters31145662083356991125146173
KB,33025662083357285
et340256620833356
al.34735662083324760
Vorasidenib,3548566208335719312615316720624121405762083385392104
a2263576208331
Dual231357620834684116132
Inhibitor24645762083145290105144160182219241
of272457620833756
Mutant279957620835593115148186208
IDH1/2,302557620831561106138159194207
in325157620831452
Recurrent332257620833570103141162184218256277
or361857620833859
Progressive3696576208335569321405861083385993119146161193227
Glioma;23805861083435974112170202214
Results26075861083357096133149171198
of281858610833756
a2887586108332
First‑in‑Human2932586108332476895118137153191213259296354386424
Phase336958610833572104130165
I3547586108315
Trial.3574586108333506597112125
Clin37105862083385267103
Cancer214059620833873109139168188
Res.23415962083346489103
2021;27:4491-9.245659610833468101133141176209219253290323355374409420
19.21406060085367084
Nabors224560610834578118158180208
LB,24746061083326982
Ammirati2577606108341101159175197230253268
M,286760610835569
Bierman29576061083365187109168201240
PJ,32186061083365568
et330760610833457
al.33856061083334862
Central346860610834075114136158192207
nervous36966061083387496214061610833168106132
system22846161083265885108141198
cancers.249561610833163101132166186213226
J2734616208324
Natl27686162083427898113
Compr289161620833771127162182
Canc308461620833772108137
Netw.32316162083437393143154
2013;11:1114-51.33986161083346799128139169196205234261288319342375406415
20.21406260085367287
Noushmehr224462610834583121147185243278316337
H,259962610834456
Weisenberger267362610835790105131166205244279300339373395
DJ,30856261083456779
Diefes31826261083456095114149176
K,337562610833449
et344162610833457
al.35156261083314760
Identification3592626108315548912714816318119821406361083316486101139178
of233863610833757
a2415636108332
CpG246763610834079124
island2612636108314415688126165
methylator279863610835792114153183199231253290312
phenotype313063610833977112151189211245285320
that34706361083226093114
defines36056361083387390107145180207
a2140646108332
distinct21876461083385379103118156188212
subgroup241464610832764103143164201239278
of270864610833756
glioma.27796461083395469107165197211
Cancer300564620833873109139168188
Cell.3206646208338678196109
2010;17:510-22.333164610833468100131144174204214249280312336366401414
21.21406560085367082
Ostrom22416562083477497119156214
QT,24746562083477988
Patil25816562083356789104119
N,271965620834557
Cioffi27956562083405593112130148
G,296265620834357
et303865620833356
al.31136562083314760
CBTRUS319265620833975108145190221
Statistical34326562083335487108124150173188220253268
Report:37196562083367121406661083397899124138
Primary22986661083355672130162183218
Brain25366661083365790105143
and270066610833270109
Other283066610834770109144165
Central301666610834073112133155188203
Nervous324066610834580101136174212238
System34996661083326289113147205
Tumors372466610833366214067610835898120148
Diagnosed23096761083476396136175214242277318
in264867610831554
the27236761083226298
United28426761083448399122157197
States30616761083335488111145173
in325567610831554
2013-2017.333067610833570103134156188223256286293
Neuro364467620834475112133169
Oncol.214068620834582112146161175
2020;22:iv1-96.233068610833468101135148183218230245278310329363399412
22.21406960085377592
Platten22596961083365286110135171211
M,249769610835671
Bunse259569610833676116144181
L,280369610833247
Wick287769610835977111142
A,304669610834358
et313169610833559
al.32176961083334963
A3307696108343
vaccine337769610833267101134150190227
targeting3631696108322577911915621407061083223979120
mutant228970610835999123158198221
IDH1253970610831563111144
in271270610831555
newly279670610833875129146180
diagnosed30057061083395690131171211240277319
glioma.33527061083405673113174208223
Nature.360470620834482104142164195209
2021;592:463-8.214071610833468101133141176208241254288324358380416429
23.21407260085367287
Polívka22457262083357288103135166199
J,246272620832436
Polívka25167262083357187102135166199
J2733726208324
jr,27747262083153646
Potužník28387262083357193131160199214246
P.310172620833540
Jak31597262083245686
léčit3263726208315498297119
nádory340072620833770109147168202
mozku362072620835796124154193
v2140736208332
současnosti.2187736208326641021341671942322702973203352524736008515
Neurol.255173620834373109130165180193
praxi.27567362083365690120135148
2021;22:206-11.291773620833468101133141176211223258292328352382410419
24.21407460085367085
Pusch22387461083357298130168
S,241874610833345
Krausert24767461083355789127153188209233
S,272274610833245
Fischer27797461083324773105143177198
V,299074610833544
et304774610833456
al.31157461083324760
Pan‑mutant318874610833566104127185222244277315336
IDH1353774610831460104136
inhibitor3686746108314528910421407561083395476113134
BAY228775610833576107
143603224077561083346597131167200232
for26527561083185677
effective27427561083345372106139163178210244
treatment29997561083224377108130188223261282
of329475610833756
IDH1336375610831560105136
mutant351275610835795117150188209
astrocytoma37347561083315821407661083224380113146171208267299
in245476610831553
vivo.25227661083324780118130
Acta26687662083386789123
Neuropathol.280476620834373109130165201237258294330345358
2017;133:629-44.317776610833468100129139169199232244279312346370407444456
25.21407760085367286
Rachdi22397761083356799137175190
A,244177610834155
Hernandez‑Tost250877610834479100138170207246280309331360394420443
H,296477610834356
et303277610833456
al.31007761083324760
Recent317277610833570102135173194
advances337877610833271103135173205238264
in365577610831452
the37197761083225994
diagnosis39403961083385385124162200227242268
and422139610833270109
the43433961083216094
treatment44503961083224478109131189224262284
of474739610833756
primary48163961083396076134166187221
CNS505039610834085117
lymphoma.518039610831547105144183221279312325
Rev55183962083346495
Neurol394040620834373109130165180
(Paris).41324062083195286107121145162172
2023;179:481-9.431740610833468101136147177207240253288324356374409420
26.39404160085367288
Reifenberger40494161083367187106141180219256277316351373
G,444341610834457
Wirsching45214161083587596124156195210249288
H‑G,483041610834568115129
Knobbe‑Thomsen497941610833675114154195231254285325363422449485523
CB,55234161083407689
Weller394042610835791106121156177
M.413542610835569
Advances422142610834180112145183215249276
in451542610831452
the45854261083226095
molecular469842610835795111146179216232264285
genetics500142610833873111146168184215243
of526242610833756
gliomas53364261083385469107165197224
–5578426108335
implications394043620831572111127142174207229244282321347
for43074362083185677
classification44044362083324779106132147165182214247268284322360
and478443620833270109
therapy.49134362083216095116149188219229
Nat51624362083437999
Rev52784362083346494
Clin53894362083375267103
Oncol.5508436208346833940446208329637892
2017;14:434-52.404744620833468100129139169200212247279315338372405417
27.39404560085377382
14.40434561083356780
Sahm414445610833367106165
F,433145610833339
Reuss439145610833672111138165
D,457845610834657
Koelsche465745610833574110126153186225261
C,494045610834054
et501545610833558
al.50944561083324862
Farewell51774561083336385120173208224240
to543845610832260
oligoastrocytoma:55194561083385570394046610833876109136159180218250284309346404436448
in440446610831552
situ44724661083264163101
molecular458946610835796112146179217232264286
genetics489046610833873111146168184216243
favor51494661083185283121142
classification53074661083314679105132147164181213246268283394047620833776
as403547620833259
either41134762083344972110145166
oligodendroglioma42994762083375368107145184219257297318355394410425463521553
or487247620833759
astrocytoma.49504762083325982103141173207232268327359372
Acta53424762083386789123
Neuropathol.54824762083427310939404862083205591127148184220235248
2014;128:551-9.420148620833468100131143173203237249284317348366401412
28.39404960085367288
Sepúlveda‑Sánchez404649620833268107145160193227267299321353386424456494529558
JM,46224962083247992
Vaz47324962083356796
MÁ,484649620835496110
Balañá49744962083356883116154186
C,517749620834053
et524849620833456
al.53224962083314760
Phase539949620833573105132167
II558349620831530
trial3940506208322435991106
of405950620833857
dacomitinib,412950620833871103140198213236251289304343355
a4497506208332
pan‑human454350620833871109132171208266299337
EGFR489350620833377110145
tyrosine50515062083225577115141156194229
kinase52935062083304684117143178
inhibitor,5485506208314529010539405162083395477114135145
in410351620831452
recurrent41735162083205487125146168202240261
glioblastoma44525162083385368106146162194221244281339371
patients48415162083397293109143181203231
with50895162083516689127
EGFR523451620833276109144
amplification.53965162083328912914516017719439405262083316486101139178191
Neuro414652620834373109130165
Oncol.432352620834583112146162175
2017;19:1522-31.451152620833468100129139169199213242272306340361393424433
29.39405360085367286
Smith404653610833390105128166
HL,42335361083447690
Wadhwani434453610835789128166217250288303
N,466753610834558
Horbinski474653610834482104144160198224254271
C.503753610834053
Major511153610835587103141163
Features52945361083336799121159180214241
of555653610833757
the39405461083226095
2021405454610833468101132
WHO4205546108358103151
Classification43755461083405587114140155173190222255276292330368
of476254610833757
CNS483854610834084117
Tumors.497454610833266124162183211224
Neurotherapeutics.52175462083437310913016518522225227330634237339405562083355671100126139
2022;19:1691-704.409255620833468101136148178209222251283317349367399432468480
30.39405660085367287
Stupp40455662083325492131170
R,423356620833549
Mason430056620835487113151190
WP,45075662083589499
van462356620833265103
den474356620833873111
Bent487256620833570108130
MJ,50195662083558193
et512956620833456
al.52035662083324760
Radiotherapy528156620833568107122160182220255276309394057620833970
plus40245762083395492118
concomitant415657620833168107139176234249272304342364
and453457620833270109
adjuvant46575762083317186123156189227249
temozolomide491957620832256114152180218233272330345384419
for53525762083185677
glioblastoma.544357620833854681061463940586208315477497134192224238
N4193586208343
Engl424858620833167103118
J4378586208324
Med.441558620835283119132
2005;352:987-96.456358620833468104138149184217250263298333366385419455468
31.39405960085366981
Sulkowski40415962083327085115152204230260277
PL,43375962083356680
Corso44365962083407798126164
CD,46195962083408596
Robinson473459620833674114129167193232270
ND,502359620834591102
et514459620833456
al.52195962083324760
2-Hydroxyglutarate52985962083345510113217119222925929339406062083385391113146167200222256
produced42126062083386097137174206240280
by450860620833869
neomorphic459360620833873112170208230270308323355
IDH496460620831560105
mutations508560620835895118151172188226264290
suppresses53916062083266410314216419839406162083265388115
homologous407361620833876134172188226266304342369
recombination44606162083215587124183222237275308329345383421
and489961620833270109
induces50276162083145291129161195221
PARP526761620833572108144
inhibitor5430616208315529010614516039406262083225980
sensitivity.403562620832762100126141163179211227249283293
Sci43446262083316075
Transl44316262083314882118142156
Med.459962620835384120133
2017;9:eaal2463.474562620833468100129139175188222254286302336367404437450
32.39406361085367186
Thiessen40476362083337287122148175210248
B,431563620833648
Stewart43846362083325387138171192217
C,462163620834053
Tsao46946362083335588126
M,484063620835568
et492963620833456
al.50056362083324760
A5086636208340
phase514763620833877109136171
I/II5338636208315405672
trial5430636208322435991106
of555663620833857
GW5720163940646208344102136169203237269300
(lapatinib)42546462083193467106139161176214229268285
in455364620831553
recurrent46196462083215588126147168203241262
glioblastoma48956462083385368106146162194220244281339371
multiforme:528064620835795110133148167205226285320332
clinical3940656108331466199114146179194
outcomes,41476561083377598129165224258285298
pharmacokinetics445865610833977109131189221253290321337375410432447479507
and497865610833169108
molecular509965610835896112146179217232264285
correlation.5397656108331689011214616119339406661083223775113127
Cancer407966620833873109139168188
Chemother428066620833874104160196217253283304
Pharmacol.459666620833469105126182217247281296310
2010;65:353-61.491966610833468100131144180214225260293326348385415425
33.39406760085367186
Torre40466762083336788110144
M,420967620835568
Vasudevaraja42976762083366793131170204237270291324339371
V,468867620833544
Serrano47526762083326788110143181220
J,499167620832436
et504767620833456
al.51226762083324861
Molecular520267620835593109144176214229262283
and550467620833270109
clinicopathologic3940686208331476299114146183223256278316354370408448463495
features44546862083185385106144166200226
of470068620833756
gliomas47756862083395469107165197224
harboring50186862083387091131170191207245284
NTRK532168620834579116152
fusions.5492686208318578398394069620833776102116
Acta40716962083386789123
Neuropathol420769620834373109130165201237258294330345
Commun.456469620833872128184220257270
2020;8:107.484769620833468101135148183196225257290296
34.39407060085367388
Turcan40487062083336687118151189
S,425770620833245
Fabius432270620833262101116154180
AWM,452270620834197151165
Borodovsky47067062083367496133173211243270300334
A,505970620834155
et513470620833456
al.52107062083324760
Efficient5290706208333516886118133168206228
induction553870620831452394071610833978112137153192232
of419471610833858
differentiation4274716108339557695131153188228250267300323339378418
and471471610833272112
growth484871610833961100153178218
inhibition50877161083155594110151167191207246286
in539571610831554
IDH1547171610831562109142
mutant394072610835795118150188210
glioma41667261083385469107165197
cells4380726108331648095121
by451872610833869
the46047261083216095
DNMT471572610834591146179
Inhibitor49117261083155391106145160183220241
Decitabine.516972610834580113128151183223238276311323
Oncotarget.55097262083458239407362083296384118139173204225237
2013;4:1729-36.419073620833468100130141176188218247282316339372406420
35.39407460085367186
Unruh404474620834482103141179
D,424174620834657
Zewde431674620833871122161196
M,453074620835568
Buss46177462083357399126
A,476174620834155
et483574620833456
al.49097462083324760
Methylation498874620835489112150180196229250266304342
and534974620833169108
transcription547674620832143761143940756208326588095134156172210248
patterns42077562083387193117151172211237
are44637562083315387
distinct45687562083385379103118156188212
in479875620831553
IDH486975620831561106
mutant499375620835895118151189210
gliomas52227562083385368106164196223
compared54637562083326912739407662083397293127166
to412276620832158
other41967662083375997132153
IDH436476620831561106
mutant448576620835895118151189210
cancers.471176620833164102134167189216230
Sci49567662083316075
Rep.504376620833465101113
2019;9:8946.516976620833468100130143178192226261296333346
36.39407760085367288
van404477620833265103
den416377620833873111
Bent429077620833570108130
MJ,44367762083548092
Brandes45447762083365790128167202229
AA,47897762083418498
Rampling490377620833568126165181196234273
R,519277620833549
et525777620833457
al.53307762083314760
RandoSeznam540677620833568106145183340622012454107155215269355
zkratek715622012447103143195232286341
2-HG3718050984368123178
D-2-hydroxyglutarát9478080955279113136181215259282325359397441458500526563587624648
MRI301980509866113136
Magnetic35928080956299143186226251268304
resonance3914808095236292136179216259295333
imaging42658080951782119163180223267
ALK3719250985191138
Anaplastic9479280954790127171189225255281298335
lymphoma12999280951753120164208251317354
kinase1670928095345396132162202
mTOR301992509868106162209
Mammalian35929280956299165231267284301337380
target3990928095256285129168193
of42019280954264
rapamycin42839280952360105142208243278295338
ATRX37110450985189135185
Alpha-thalassemia/mental94710480954764108152188214239282319336372402432472538555591621685724768792829846
retardation,18111048095236287124148191228252269312356370
X-linked21981048095446684101144178216261
MYB3019104509866112159
Myeloblastosis359210480956298137154197242260296326353394425441471
oncogene408010480954386123164209249292332
BRAF37111650984693146187
V-Raf94711680954164106143165
murine1129116809566108132150192232
sarcoma13791168095296791126168234270
viral16671168095365478115132
oncogene181711680954286122164209248291331
homolog216611680954286152196213257301
B2485116809540
MYBL3019116509866112159200
13235116509843
Myb359211680956298143
proto-oncogene375211680954569111136178204249293329371416455498538
like43071168095173468107
14431116809539
CDK4/6371128509847102150192220262
Cyclin-dependent94712880954677113130146189215260300344385428472512555579
kinase15441288095335295131161201
4/6176212880953967104
NEC301912850985496144
Not359212880955195119
elsewhere37291288095385685125183227266290329
classified40751288095365389119149166188206245290
CDKN2A/B371140509847102150205248300329376
Cyclin-dependent94714080954677113130146189215260300344385428472512555579
kinase15441408095335295131161201
inhibitor176214080951760103120164182207249273
2A/B205314080953986118159
NOS3019140509854112153
Not359214080955195119
otherwise372914080954267110150174234252281321
specified406714080953074115152168190208247292
cIMPACT-Now37115250983658125171219265309331387434494
Consortium94715280954687131161204228256273316382
to134615280952567
inform14301528095176081124148214
molecular1662152809565109127166203246263299323
and200315280953679123
practical214415280954468106142169187223260277
approaches243915280953680125149192229265308348378
to283515280952566
CNS94716280954696133
tumor109816280952467133176201
taxonomy13161628095256298140184227293328
–1661162809540
not171916280954386111
official18471628095436589107143160196214
WHO2078162809566117171
NTRK301915750985497143191
Neurotrophic359215780955191134157200224248290335379396432
tyrosine40421578095246287129160176219259
receptor43181578095246299137182207249273
kinase46081578095345396132162202
CNS371174509847101144
Centrální94717480954684127151175213230273290
nervový125417480954383107146188225263
systém15351748095306797123161227
OS301917450985698
Overall359217480955492130154192209226
survival38351748095307296135153190227244
DNA371186509855110161
Deoxyribonukleová94718680955292136170208233250295339382425459478517561597634
kyselina159918680953472103142160176219256
PARP301918650984592138184
Poly(ADP-ribózo)polymeráza359218680954082100135157204256297320345363407451483525545589633651687753793817854888926
EANO37119850984194148206
European94719880953779102145189230266309
association12731988095376797140177194230255272315358
of164919880954264
neuro-oncology173119880954282125149191217262306342384402445490526
PCV301919850984593143
Prokarbazin,359219880954063106140178202247284318335378392
lomustin400219880951760126169198224242285
a4304198809536
vinkristin43581988095365497131156173203229246289
EGFR37121290984195137182
Epidermal9472132095378199143182206273309326
growth129121320954367109167195239
factor15472132095215995122164189
receptor17532132095246299137182207248273
PFS301921290984585127
Progression-free359221320954063106150174213243273290333376402424449487527
survival41372132095307296135153189227244
FGFR137122490984194136181222
Fibroblast9472252095375498122164209227264294320
growh128422520954467110168211
factor15132252095215995122164188
receptor17192252095236299137182206248273
12009225209539
PR301922490984590
Partial359222520954076100128145181198
response38082252095236292136180224254293
GBM371236909853101168
Glioblastoma9472372095506885128172190227257283325391427
multiforme1392237209565108125150168189232256323362
PTEN301923690984588131186
Phosphatase359223720954083126156200244280305342372412
and402123720953679124
tensin416223720952563106136153195
homolog437523720954386152196214257302
G-CIMP37124890985381131152220266
Glioma9472492095506885128194230
CpG119524920954690141
island1354249209516466399142186
methylator1558249209566105130174208226263287329353
phenotype192924920954487127170214238276322362
SD301924890984297
Stable35922492095376198142160200
disease38092492095446190130166196235
H3F3A37126190985497138180230
H394726220955089
histone10532622095436089116157201241
family131126220952159125141158194
member1523262209565105171215256280
3A182026220953985
SHH301926190984296151
Sonic359226220953781124141177
hedgehog378726220954382127171211254297342
HR371273909854100
Homologní94727420955094160204221265309352369
rekombinace13342742095236296139205249267310346383421
TACC1/3301927390984289135181222245289
Transforming35922742095375694137167189232256322339382426
acidic40362742095367390134151187
coiled-coil-containing42402742095367895112151196221259301319336361399441484508545562605622665709
protein496727420954468110135173190233
1/3521827420953963103
IDH1/237128590982177132172196239
Izocitrát-dehydrogenáza9472862095175092129146171195232257279325364408442486510552597636679716749787
1/2175228620953963103
TERT301928590984284131174
Telomerase35922862095377289133199238262300330369
reverse39792862095236298137161192232
transcriptase42282862095254986129159196219237281306343373413
MAPK371297909866118163210
Mitogen94729820956280105147191231274
activated123929820953672100117154191215253298
protein155529820954468111135173190233
kinase18062982095345295131161201
TP53301929790984288130171
Tumor359229820953775141184208
protein381829820954468111135173190233
p53406929820954482119
MDM2371309909866122189232
Murine947310209562105129146189229
double119331020954487130175193232
minute144331020956582125167193231
21691310209540
WHO3019309909870124182
The359231020953782121
World3731310209565107131149193
health394131020954383119136161205
organization416331020954367110147190207239277302319362406
MDM4371321909866122189233
Murine947322209562105129146189229
double119332220954487130175193232
minute144332220956582125167193231
41691322209540
WNT3019321909870125167
Wingless/integrated359232220956684127171188227258288317335378402440485509546571609654
MGMT371333909866120188230
O-6-Methylguanin94733420955481123149213253278321356374418460497540557600
DNA1564334209552104150
methyltransferáza1732334209566105130174208226251275313356386408447471508542580
YAP1301933390984693138179
Yes-associated359233420954075106129166196226269306323359384422467
protein407633420954469111135174191233
14327334209539
MHC371345909866121169
Major94734620956299116159184
histocompatibility11483462095436089115157194236302347384408426470487504521546585
complex175034620953677144188206245281
ZFTA301934590984587131178
Zinc359234620954360103139
finger37493462095213982126166189
translocation39563462095254986129159176219256293318335378422
associated43953462095366696140177194230254292337