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pohlaví.25622410012157111166189236281304324
Nejvíce29062410012166116138186209252300
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ženy2510255001214290143187
nad27122550012155101155
muži.28822550012183135176198217
V31142550012155
České31872550012157104142186233
republice3435255001213381135189243266287330377
je340269001212473
více429269001214871114162
než6062690012156105147
milion7682690012183105128149203257
migreniků.10412690012183105160191240294316361415434
Většina14912690012156102134173195249296
z18032690012142
nich1864269001215577121174
trpí2054269001213364120143
migrénou22122690012184106160191240294348402
epizodickou,26302690012150105128169223279300344389441495515
nejméně31612690012155104127209258312361
dvacet35382690012156103151194242274
procent340283001215789142187235290321
z6812830012143
nich743283001215577121175
pak9382830012157105150
trpí1108283001213365121144
formou1271283001213084116198253307
chronickou,1598283001214498130183238260304349402456476
která2094283001214782130162210
se2323283001214089
významně2432283001214898142197244326380429
odráží28812830012155111143190233255
na31562830012155102
kvalitě3278283001214797144167189221269
života3567283001214365112165197245
nemocného3402970012155105188242286341390445499
i8582970012124
jeho901297001212473128182
rodiny.1103297001213286142164219263278
V14012970012156
léčbě1476297001212373117173223
migrény17182970012183106160192241295340
zažíváme2077297001214392134157204251334383
v24802970012148
posledních25472970012157112150172221278332354398452
letech3018297001212473106154199253
revoluci.3290297001213382128181204258302324343
Máme365329700121801283403110012183133
k4923110012146
dispozici558311001215678116172227268290334356
specifickou932311001214095145190212240266309355408462
medikaci14123110012184133190212257306349371
akutní1802311001214894148181235257
i20783110012123
profylaktickou2120311001215789143171221244291336371393437483535590
v27283110012148
různých2796311001213287129183228270325
formách3139311001212983115198245289343
podání.35013110012156111168215269291311
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slova:686327001244472131183236261
migréna,9693280012183107162195245300348369
akutní1360328001214895150183238262
léčba,1643328001212374119176224245
CGRP,19103280012158119173227236
gepanty,21673280012156107164212268300350366
rimegepant.2554328001213356139190247297354403458491512
Gepants3403550012468122183237296332377
–7383550012450
new8093550012459112188
moleculs10173550012486145173227273332360404
in1441355001242786
migraine15483550012486114173211264292351404
treatment1973355001243676129183219307360420457
Migraine3403730012180103158190237259313363
is726373001212462
a8113730012149
frequent879373001212962111167221270324356
disabling1258373001215779117165221244266320375
disease.1657373001215678116166213251300320
The20003730012150105155
worldwide21783730012174127159182237310333388438
prevalence2639373001215789138185232254304358402450
of3113373001215583
migraine32203730012183105160192239261315365
is3609373001212361
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to681387001213386
be7883870012157107
between9153870012157107140215263313368
10–151303387001215297150194238
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Migraines16733870012180103158189237259313362401
often2095387001215583118166221
start2337387001213972120151186
already2544387001214871102151198254300
in2865387001212377
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when34223870012174128178232
the3675387001213387137
ratio340401001213380112134188
of546401001215583
girls648401001215678109132170
to837401001213386
boys9414010012157112157196
tends1155401001213381136192230
to1404401001213386
be15084010012157107
higher1633401001215678133187237269
in1920401001212378
boys,20164010012157112157196216
and22504010012148103158
during24274010012156110141164218273
puberty27194010012157111167217249283332
the3070401001213387136
numbers32254010012155109191247297329368
even3612401001215097145199
out.3404150012155109141162
As5204150012162101
age6404150012148103153
continues,811415001214598153184206260314363402422
the1252415001213387136
ratio1407415001213380112134188
leans1614415001212373120174212
more18454150012183137169218
towards2082415001213386158205237292330
the2431415001213387137
female2586415001213079161208231280
sex.2885415001214089135156
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it3461415001212355
mostly35354150012183137176209231277
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adults6464290012149106160183215255
of928429001215684
working10394290012174128161208232287343
age,14084290012149105155174
where16094290012174130180212262
women18974290012175129212263318
already2242429001214871103153200257304
significantly2573429001214062118173195224250294342398429452499
outnumber30994290012155110143198252336392443475
men.36014290012184134190210
There3404430012150105155186235
are601443001214879128
more7554430012183137169218
than999443001213387134188
a12134430012148
million12804430012183106128150172226281
migrainers15864430012184106161192240262316365397437
in2048443001212478
the2151443001213387137
Czech23134430012158102151196250
Republic.25884430012154104160214270293315359379
Most29934430012180135173206
of3224443001215583
them3333443001213387137219
suffer3578443001213993121153202234
from340457001212962115198
episodic5594570012150106128167221277299343
migraine,9234570012183105160192239261316365384
while13284570012173128150172222
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least1671457001212473120158191
twenty18834570012133108156211242291
percent21954570012157107139182230285316
of2532457001215583
them2636457001213387136219
suffer2876457001213993121153202234
from3131457001212962115198
the3350457001213387136
chronic3507457001214599130184239261304
form,340471001212983115198218
which5804710012174129151195249
significantly851471001214062117171193222247290338392424446492
affects1366471001214876108157202236276
the1664471001213388137
quality18244710012156110157179201233282
of2129471001215583
life223447100121244674124
of2380471001215583
the2486471001213387136
patient26454710012157105136158207262293
and29614710012148102158
her/his31424710012155105137166221243281
family.3446471001212977159181204250265
In3734471001212478
recent340485001213382126174229260
years,621485001214795142173213233
we8744850012174122
have10174850012155102148196
experienced1233485001215096153203235257306361405453509
a17634850012148
revolution1830485001213382128181204258290312366421
in2271485001212378
the2369485001213387137
treatment2526485001213365113160192274324378410
of2956485001215583
migraine.30594850012184106161192240262316366385
We34644850012185131
have36164850012155102148196
available340499001214893140162184231286309358
specific713499001214095145189211239264307
acute1036499001214891145176224
and12764990012148102157
prophylactic1449499001215688141197251295318365409443464508
medication19724990012183133188210254301332354408462
in2450499001212377
various2542499001214895126149202256294
forms2852499001212983114196234
of3102499001215482
administration.32004990012148103185207261283320353384431462484538592612
Key3405150012461113164
words:5255150012475133171232276302
migraine,8485160012183107162195244267322372392
acute1261516001214993148181231
treatment,1513516001213365115163196279330385418439
CGRP,19735160012158119173227236
gepants,22315160012155106163212267299340361
rimegepant.2613516001213356139190247297354403458490512
Migréna480552001097293143172216266308
je809552001092266
třetí896552001093058102132152
nejčastější1069552001095094115155198233263307328362383
neurologickou1472552001095095144173221242292342362402443491540
nemocí.340566001095094168217257277295
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je966566001092266
i10465660010921
jednou1084566001092266117166215263
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nejvíce1417566001094994114157178217260
handicapujících1691566001095092141191211250293340580001095199119139178197236284
nemocí637580001095094167215255274
na925580001094991
světě1029580001093678121150193
(Nežádal,1235580001092582126164207256298318335
2019).1584580001094689130170192208
Podle1805580001094894144164208
amerických3405940010943118163192212252293338377426
odhadů7825940010949100149192243291
je1089594001092266
migréna1171594001097595145174218268310
třetí1497594001093058103132152
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let34062200109226898
strávených46362200109366797141184228279321361411
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invaliditě.961622001092272115159180201253274304349366
Léčba1352622001094389131182227
migrény1603622001097798149179224275317
je1944622001092369
také340636001092972112154
finančně50863600109254896137185224272315
náročná,837636001094990118165205253294312
jak1162636001092263103
pro1279636001095078126
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tak1761636001093072112
pro1887636001095078126
pojišťovnu,3406500010951101122142177207255297347396414
tak771650001093073115
pro903650001095180129
zaměstnavatele.1049650001093983157202237267316359401444472516537582600
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se,86066400109358097
že972664001093882
migrénou1069664001097394143172215265313362
trpí1446664001092957108129
miliarda1589664001097495115135177206255298
lidí190166400109214191112
na340678001095093
celém449678001094085107152227
světě.692678001093680124155199217
V9256780010950
České994678001095296132174218
republice1228678001093075126176227249270311355
je1599678001092267
přibližně1682678001095181102153175196235285330
kolem340692001094291113159234
milionu597692001097596117138188239288
pacientů908692001095195136157203253283332
s12636920010935
migrénou,1317692001097597147177222273323373392
z17316920010939
čehož1789692001094085135185223
nejméně340706001095197120197243295342
50708706001094793
000828706001094796145
žen999706001093985137
a11627060010944
mužů12267060010976127167218
trpí1470706001093061114136
migrénou1632706001097698150180227278329380
chronickou.340720001094090120169220241282324373423442
U4807340010960
migrény5617340010978101154185233285329
se921734001093785
nejedná1038734001095199123171225278323
pouze13937340010953106158199247
o16727340010951
bolest,17447340010953105129177215248268
která340748001094377123153199
pacienta565748001095298140161208260290336
paralyzuje.927748001095298128173196240282333356403422
Nemocný13757480010961108185236279330373
zažívá1774748001093986126148193239
i3407620010921
další381762001095196118154176
nepříjemné583762001095097150180202225272348399446
projevy1055762001095283133155202246292
vegetativní,1374762001094389141188219264294316360412434453
jako1853762001092367110160
je340776001092269
fotofobie,436776001092778109159187238291314361380
fonofobie,843776001092678130181209260313336383402
osmofobie,1271776001095187164216243295348370417436
nauzea1734776001095196147187234279
a21405520010945
zvracení.2206552001093987119165208254307329349
Souběžně2583552001094597150203251292345392
s30035520010936
bolestí30605520010953106129177214246269
se3356552001093785
objevuje34685520010951105128176221273296344
i21405660010921
neschopnost2182566001095198135177228280333385436473505
soustředit2714566001093688139176208238285338360391
se,3132566001093684103
někdy3261566001095198142194238
i35265660010921
potíže35685660010952104135157197244
s21405800010936
výbavností2195580001094490143188230282332368399421
slov2641580001093658108152
a28185800010944
potíže28825800010951102133154194239
s31475800010936
jemnou3202580001092269145195246297
motorikou.352458000109761261572062372582140594001094291141160
Jednotlivý2317594001093379131181231261282304347393
záchvat2727594001093984125174217261290
může30345940010975125164209
až3260594001094382
u33595940010950
803428594001094693
%35385940010971
pacientů36265940010951951361572140608001094596126176
předcházet2342608001095181127179220270314354400431
předzvěst2798608001095282127180219265310346377
záchvatu3201608001093984125176218263292342
neboli3569608001095096149199222243
prodrom2140622001095283135188219270348
(nápadné2514622001092676121174219272324371
zívání,2912622001093962107152204226246
únava,31856220010950102147191236256
chutě3468622001094193144175221
na3716622001095196
sladké2140636001093657101152194239
a23956360010944
jídlo,245863600109224394115165183
časté2658636001094084120151195
močení,28706360010975125166211261282301
žízeň,318863600109396099144195214
podrážděnost,3418636001095110215418422826731836421406500010950100136166186
agresivita,2350650001094394123169205226269291321366385
ztuhlost2759650001093871121171192242278309
šíje,309265000109355679125143
průjmy,3259650001095181131153228270284
přecitlivělost3567650001095181127168189219214066400109214286131152202238269
na2425664001095094
světlo,2535664001093580124155176226244
kognitivní2795664001094291142192213244265308359380
potíže)31926640010951102131152192237260
(Recobrt,3468664001092674120161210262292324344
2021).2140678001094589132173191208
Přibližně236267800109477595145166186224272317
u26936780010949
20–302759678001094690137180225
%29996780010969
migreniků3083678001097494143171215264284325374
může34716780010974122160203
být3689678001095091123
před2140692001095181126178
nástupem2336692001095093129160210261307383
vlastního2737692001094365109144175225246298348
záchvatu3103692001093984125174217261290340
přítomna3461692001095181102133182257307351
aura2140706001094494124168
(rozšiřující2334706001092653103142180201231281303325366387
se2747706001093682
skotomy,2855706001093679128158208284326341
světélkující3222706001093681126156202224267317339361402423
fosfémy,36717060010926771132140720001092774153196211
parestezie2378720001095399130177214247293334357404
jednostranných2809720001092370124176228265297328374426478521563615
končetin,3450720001094494147189236267290342362
neobratnost2140734001094994143194223266295344392427457
horní2612734001094998127177197
končetiny2824734001094289139178222251272320361
a32007340010942
jazyka,3260734001092264103147189233251
závratě,3526734001093882123153196224268286
potíže21407480010951102132153192237
s23977480010936
expresí,2452748001094588140170215251272291
dysartrie,2762748001095194130175204237266288334352
výjimečně3133748001094490112133208254296346391
ataxie).3544748001094373117160182227251268
Migréna2140762001097395146176222273317
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