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Neurol.1374804001075593139165209227243
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4701298020012657113169
PŘEHLEDOVÉ341200012660124182256312369444520587645
ČLÁNKY1008200012660115187259327395
RAVULIZUMAB34136001063375110151182200233274327368403
V760360010636
LÉČBĚ8123600106296196132164
PACIENTŮ99236001063369103120152193226267
S1275360010630
AQP4-IgGpoz1321360010638771121431711882232621584360062193955
NEUROMYELITIS165436001063971112147188242278310342359391409442
OPTICA211136001063874105123158200
A2326360010638
ONEMOCNĚNÍM238036001063880111166207242283315357374428
JEJÍHO2824360010622548098139180
ŠIRŠÍHO30193600106314883117134175216
SPEKTRA32513600106316596132166202244
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v17729200298127
léčbě1948920029866191300443569
pacientů25669200298143269376441566707792932
s34011800298104
AQP4-IgGpoz49311800298157321461585669741881104415381200017484165229
neuromyelitis181511800298141266406496634839958108011471211129813641467
optica333011800298139281368434541667
a34014400298127
onemocněním515144002981392784046107488559951121126213261531
jejího20951440029870195262327470608
širšího275114400298104169259363428571709
spektra350814400298104247373503595687811
MUDr.3401840013793168245287311
Petra6731840013764120161204261
Nytrová1,9571840013776133176219283340398134718500803613821840013729
Ph.D.,14331840013764127156235261291
MUDr.17461840013793168245287310
Ingrid2079184001373196160203232298
Menkyová,23991840013793152217277338400457515544
Ph.D.1,29651840013764128157235261321818500803651
23282185008036
1Neurologická3402000078333712000013372128188223283309369431456505555609
klinika1003200001335279104164189240294
a13202000013353
Centrum13962000013364117178213249309400
klinických1820200001335178103163188237288343391451
neurověd22942000013361116176212271323376439
1.2756200001335673
LF28532000013352104
UK29812000013371130
a31342000013353
VFN32112000013361115185
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klinika1005215001335279104164189240294
SZU13222150013354113183
a15282150013353
UNB,16052150013371143202225
Bratislava1853215001336095148183208251276328379432
Ravulizumab3402660012154102149204228251294349432480537
je902266001212474
monoklonální10012660012184139194250297322377433481504559582
protilátka1608266001215790145177201224272304351400
proti2033266001215790144177200
C522582660012158110
složce2393266001213963118160205254
komplementu.26712660012147101185241265316399450506538593614
Tento3310266001214993149181235
léčivý3570266001212474120143191241
přípravek340280001215688111166199246292340386
byl7432800012156101125
schválen885280001213983137182230252302356
řadou1258280001213280135189243
lékových1518280001212473119172218267310364
agentur18992800012148102152206238292323
v22392800012148
léčbě2306280001212473118173223
AQP4-IgGpozNMOSD254628000121601251782242572823384022948280007133669030392800012165144212259324
na33802800012155102
základě3499280001214291136161208263312
klinické34029400121477295150173218264313
studie678294001214074129185209259
CHAMPION-NMOSD.9622940012158122183263317339409475508576656726774840858
Stejně1845294001214981130154209259
jako2129294001212573119173
ekulizumab,2327294001215097153176199242297380428485504
ravulizumab2856294001213382128184207230273328411460516
poskytuje33972940012157113152199249286340364414
vysoce340308001214899138194239288
efektivní651308001215080130177213236284340363
prevenci1037308001215790140187236292337360
rozvoje1419308001213388130180234258308
relapsu1750308001213382106154211250305
u20773080012155
NMOSD.21543080012165146215264329348
U25243080012165
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molekul28553080012184139163213261316339
klinické321730800121477295150173218264313
studie3553308001213973128185208258
prokázaly340322001215789143190239282331354401
více759322001214871116164
než9413220012155105148
90%11063220012151103183
snížení1306322001213994117160209264287
rizika161132200121325598121167216
relapsu1844322001213382106154210249303
ve2164322001214897
srovnání2278322001214071126172228276330353
s26493220012139
placebem.2709322001215781128173221278328411432
Ravulizumab31593220012153101147202226248291345428476532
na37083220012155103
rozdíl340336001213286127182205229
od5863360012155111
ekulizumabu714336001214996150173195237291373420476530
má12613360012182129
delší14073360012156106129167189
biologický1613336001215780134157211267289333379428
poločas20583360012156111135189233281319
umožňující23943360012155136191232286340363385429451
prodloužené2862336001215689142198221275329372420475525
dávkovací34043360012155102148194247293341385407
schéma340350001213984138188271319
ze676350001214392
dvou7863500012156103157211
na10153500012155103
osm1135350001215593175
týdnů.1328350001213382137192246266
U16113500012165
pacientů16963500012157105149172221276308362
léčených2076350001212373118167222267310364
C524583500012158109
inhibitory2584350001212478133156212235268321354403
je3005350001212474
zvýšené3096350001214393143182232287337
riziko345035000121335698121167221
závažných3688350001214392340364001214795137191235278332
meningokokových6893640012182131185208262316370416469515567613663705759
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a17663640012148
proto1834364001215688141173225
je2076364001212473
vakcinace2166364001214795140183205259305349397
povinná25803640012156110156179233287334
před2931364001215688136192
zahájením3140364001214291145191214263318340422
léčby.3578364001212473117172217233
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slova:692380001244472130182235261
ravulizumab,981381001213381128183207230273328411459516535
ekulizumab,1544381001215097152176199241297380428485504
komplementový20753810012147101185241265316399450506538592639690
systém,2792381001214088127161211294315
meningokokové31343810012184134190213268324380427481528582629678
infekce,340395001212379108158205249298317
neuromyelitis6793950012155106161193248332377426451473507530569
optica12693950012155112145168213261
a15523950012148
onemocnění16213950012155111161245300345401451507530
jejího217239500121247498121179234
širšího242739500121406395135158216271
spektra.2719395001213996147194230263311332
Ravulizumab3404220012459113165224252280328387474527587
in948422001242786
treatment1054422001243776130183220308361421457
of1532422001245792
AQP4-IgGpos1644422001246613619524828431537444320884230073357096
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Optica28604220012472133170199244298
Spectrum3404360012454114168214253292350437
Disorder797436001247098142200239299353392
Ravulizumab3404540012154104151208232255299355439488546
is915454001212363
a10074540012149
humanized10784540012156112196245301325368419477
monoclonal15844540012185141198254300324380436485509
antibody21224540012149105138162219276334382
targeting2533454001213483117173224258282338395
the2957454001213490141
complement31274540012145100185242267318403454511544
C537004540012159111
protein.340468001215790145178228251307328
This6974680012150106130169
drug894468001215790145202
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approved15404680012148105163196251298348405
by19744680012157103
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regulatory2499468001213383140195219267300354387438
agencies29654680012148105155211257280330370
worldwide33634680012174129162186243317341397448
for340482001212984117
the476482001213388138
treatment633482001213366115163196279330385418
of1069482001215584
AQP-411724820012161128181211266
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NMOSD19814820012166147216264330
based23304820012157105145195252
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the2730482001213388139
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of3179482001215584
the3282482001213388138
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trial.84749600121336587134157177
Similar1041496001214971152175197244276
to1334496001213285
eculizumab,1436496001215094148171193235289370417473492
ravulizumab1945496001213279125179202224266320402449504
offers2466496001215483114164196235
highly2718496001215577132186209255
effective2990496001214978110159204238261308356
prevention3363496001215688137183231286317340394448
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NMOSD4395100012164143210257322
relapses.777510001213281104150206244293331351
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molecules13545100012182136159208252305328377415
demonstrated17855100012156105186240294332365396443475523578
more23805100012182136168216
than2612510001213387133187
90%28165100012150101179
reduction3012510001213280136189233267289343397
in3425510001212377
relapse3519510001213280103150205243292
risk34052400121335695142
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to954524001213387
the1064524001213388138
placebo1225524001215681128173222279335
group.1582524001215689143199256275
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a26045240012148
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half-life29695240012156104127157186211234263313
allowing330552400121487194150222246301357
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from1340538001213063118201
two15655380012133109163
to1751538001213387
eight1862538001215074129185217
weeks21025380012174123174222264
compared2389538001214599183239288321370428
to2840538001213387
eculizumab.2951538001215095150174197239294378426482502
Patients34775380012153100133156206261294334
taking340552001213382129154210266
C56345520012158111
complement773552001214599183240264315398449505538
inhibitors1339552001212479135158215238272326359400
have17675520012156104151200
an19955520012149104
increased2128552001212378124156206255294345402
risk255955200121325695142
of2730552001215584
serious2842552001214091124147203258298
meningococcal31685520012184135190214269325381427481526570619643
infections,340566001212379108158203239262317373412433
therefore794566001213388138171221251306339389
vaccination1204566001214896141185208263311343367422477
is1702566001212463
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Key3405820012461111161
words:5175820012475131169228271297
ravulizumab,831583001213280125180202225266320402449505523
eculizumab,1371583001215094148171193235289370417473492
complement1879583001214597179235258307389439493525
system,2421583001213986125158206288308
meningococcal27465830012182132186209263317371416469513556603626
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neuromyelitis3405970012155106161194248332378427451474507530569
optica9305970012155112145168213262
spectrum1213597001214096147193228261316399
disorders.1634597001215679118173206262313346386407
Úvod3406470014780142208279
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nervu2739664001095096126172222
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neuritidou3351664001095095145175197227248299349399
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jedno2303678001092267119169219
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Recommendations406842800853977112153216278317359402439465483525568598
for46984280085216389
the481842800852466105
Conduct,495442800854283126169210245272290
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and430843900853373113
Publication443443900853776117134151183218242259298338
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Scholarly485743900853467106146163198221239273
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Medical537843900855693134151183218235
Journals,406845000852666105129169204221250265
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in462845000851756
December470445000854784116152211252289313
2018,503645000853673107140156
including52124500085165688105145185203242283
patient55144500085407540684610085234076116140
consent422246100853270110138175215238
where447546100855191128151187
appropriate.467746100853474115139178219243260295319354369
Conflict406847500874282125150171191224252
of433447500874066
interest:44144750087196188126154192224251271
Not406848600854686110
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Consent406850000874282125156194237263
for43465000087236593
publication:445350000874284127148168201239266287329371390
Not406851100854686110
applicable.419351100853374115132149182217257275311326
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z4736528008530
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ČR512953900854078
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