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www.neurologiepropraxi.cz34080400107651332012142633073553814284484965465656086586857327828098518919109269661005
/34948040010732
Neurol.3570804001075593139165209227243
praxi.3829804001074672114152170186
2025;26(1):17-234031804001074487128172185229272295335353367404441464503547
/46238040010731
NEUROLOGIE47008040010758102158205268310370429450494
PRO5215804001074591154
PRAXI5390804001074692148201221
1756558020012657109
HLAVNÍ4945200012670127198263336370
TÉMA5337200012657114204274
Genetika359736001063769110142176193229271
Alzheimerovej388336001063869104145177195248280316357394426453
choroby435136001063374115151191227264
a4630360010638
demencie468436001063769124156197232250281
s4981360010631
Lewyho502736001062962123161203244
telieskami52863600106306294112143178213255309326
Genetika3409200298164291432557645711840966
Alzheimerovej1355920029815722033347560066687199710881225134714691536
choroby29399200298109249386476614756877
a34011800298127
demencie515118002981432694756017428499141039
s160311800298104
Lewyho175511800298123248428559699836
telieskami2640118002988821328034446957370282910341098
prof.3401580013766108172210236
MUDr.5981580013793168245287310
Stanislav931158001375998157222252300330389446
Šutovský,13991580013759123163227284330391451476
PhD.1,18971580013764128204230212015900803621541580013729
RNDr.22051580013765142219261285
Robert25121580013765128194253296338
Petrovič,28721580013764121161204268325355405436
PhD.2,33301580013764127204230356315900803636011580013729
RNDr.36521580013765142219261285
Katarína39591580013767126166224266296361419
Kolejáková,44001580013768129160218250308368430487545575
PhD.2,49971580013764127204230522915900803652671580013729
prof.3401730013766108172210236
MUDr.5981730013793168245287310
Peter9311730013764120161219262
Turčáni,12151730013760117159209268332362391
PhD.1162917300137641272042301852174008036
1I.340189007833371189001332650
neurologická4441890013361116176212271297357419444493544597
klinika1065189001335178103164188239293
LF13811890013352105
UK15091890013371131
a16631890013353
UNB,17391890013371143203225
Bratislava1988189001335995148183208250276328379431
2Ústav3402040078333732040013371113150203254
lekárskej650204001332681132186221265316369395
biológie,1069204001336288148174234296321376397
genetiky14892040013362117178233269294345400
a19122040013353
klinickej1988204001335279104164189238289342368
genetiky23792040013361116177232269293344399
LF28022040013351104
UK29292040013372131
a30832040013353
UNB,31602040013371143202225
Bratislava3408204001335995148183208251276328379432
Genetika3402550012164114168216248270315363
neurodegeneratívnych7182550012155104157188241297345400449503552583630661683729784828870923
demencií16572550012155104186235289332354375
je2047255001212573
turbulentnou2136255001213286117172226248296350381435488542
témou2693255001213380162215269
súčasnosti.2977255001214092136183220274327365397419438
Na34302550012165112
jednej3558255001212472128182230253
strane340269001213972103150203252
sa607269001213987
postupne7092690012156111148181234289343392
zvyšuje1116269001214292141178231253302
množstvo14332690012183137190231270303352404
génov18522690012155104158211257
zapojených2124269001214391146200222271325369411464
do26042690012156109
patogenézy27282690012157104135187242291345394435484
neurodegeneratívnych32272690012155104157188241297345400449503552340283001213380112134181236280323377
procesov,733283001215789142187235273327373388
na11372830012156102
druhej1255283001215788143197246269
strane1540283001214072104151205255
vystupuje1811283001214897136169223278333355405
problém2231283001215789143199222271354
s26012830012139
interpretáciou2659283001212377109157189245277326358406449471525579
dosiahnutých32542830012157111149171218272326380412460503557
výsledkov.340297001214898136159208264310363409424
Alzheimerova781297001216183125179229251334383415468515562
choroba1360297001214498153184238294342
(AD)1718297001212988153178
a19132970012148
demencia19802970012157106188238293337359405
s24022970012140
Lewyho2461297001214796168217273327
telieskami2804297001213382105127176214260308390412
(DLB)3233297001212893140192218
predstavujú34672970012157891381942332653133403110012148103126179
v5363110012148
súčasnosti604311001213993136184222276330369401423
dobre10443110012157111167199248
definované13093110012156106134160214268314361416465
klinické179131100121477193147169213259306
jednotky.2114311001212574130185239271316365381
Alzheimerova2512311001216183125180229252334383415469515562
choroba3091311001214599153185239295343
má34513110012183130
jasne3598311001212471110164213
určené340325001215587130178232282
kauzálne641325001214795149191240262317366
gény10273250012155105159204
(APP,1251325001212812803250012157106154168
PSEN1,1465325001215095140200244259
PSEN2)174032500121519614020124719843250012128
a20323250012148
významný2099325001214998142197244326380425
gén25433250012156106160
susceptibility2723325001213993131175223279311333389412434456488537
(APOE).32793250012129330932500121571061722183530325001212846
Popri35963250012153105161193215
nich340339001215678122176
sa542339001214088
postupne6563390012157112150183237293348398
objavujú10803390012155111134181227282304358
nové14653390012155109156204
gény16953390012156106160205
susceptibility,1926339001214093132176224280312335390413435457489538554
ktoré2506339001214782135167216
modifikujú27483390012184138194217245270316371393447
klinický322133900121477194148170214259309
obraz,35563390012155111144191234255
vek340353001214998146
nástupu5133530012156105144178233290346
ochorenia8863530012156101157212245295351374422
a13353530012149
spolu1404353001214198154178233
s16643530012140
APOE17253530012158108175223
vytvárajú19743530012149100136187236268317340395
komplikované23963530012148102187244267290337391438487542593
genetické30163530012157108164214248271315362411
pozadie.34543530012158114156206263286337357
Demencia3403670012167116199249303347369416
s7733670012139
Lewyho831367001214796168218273327
telieskami1174367001213482105127176214260308391413
je1603367001212474
heterogénnejšou16933670012156105137186218271327376431485535557595650704
entitou24133670012150105136158190244298
ako2727367001214894147
Alzheimerova2890367001216184125180229252334384416469515563
choroba3469367001214599153185238294342
z3403810012143
klinického40238100121477193147169212258305360414
aj832381001214871
genetického9193810012156105159209241263307352400454508
hľadiska.1443381001215679125180202240286334354
Génmi18133810012165115169251273
susceptibility2102381001214093131175223279311333388411433455487536
DLB26543810012166113165
sú2835381001214093
viaceré2944381001214871118161209241290
gény32503810012155105159204
zdieľané3470381001214298120169192238292342
s3403950012139
Alzheimerovou398395001216183124178227249330379410463509561615
chorobou,1028395001214598151183236291345399419
Parkinsonovou1462395001215398129175198252289343397451496548602
chorobou2079395001214598152183236292346399
(PD),2494395001212879142167184
frontotemporálnou2694395001212961114168199251282330412467521552599621675728782
demenciou34913950012156105187236290340409001214567121176
(FTD)543409001212875126193218
a7884090012148
inými855409001212478123207229
neurodegeneráciami.11114090012156105160192245302352408458512562594642686708756838861881
V20184090012156
našom20934090012156104142196279
príspevku2399409001215789112150206256303350405
sa2830409001214088
snažíme2945409001214094141184206289339
sumarizovať3310409001214094177224256279321375421469501
genetické3404230012156105160209242264308353401
pozadie7624230012157112152201257279328
AD11114230012161126
a12584230012148
DLB,13264230012166113166185
charakterizovať1532423001214599146177225271306354386408450504550597630
ich2182423001212468122
podobnosti23244230012157112168223279333388426459481
a28254230012149
rozdiely2893423001213386127182205254277323
a32374230012148
poukázať33044230012157112166212260303352384
na37094230012155102
komplexnosť3404370012147100182238261310356411465504537
neurodegeneratívneho8964370012156105160191245301350406455510560591639670692740795844899953
ekosystému1868437001215197149188235273306355437491
(„neurodegeneratómu“).23784370012129652445437001215398149180231283327378423475520551600630680760811325743700121356582
Kľúčové340453001246088148191247296346
slová:700453001244269125175225249
Alzheimerova964454001216082122176224245326374405457502548
choroba,1527454001214497150181233288334353
apolipoproteín18954540012148102156178199253307361392445475522544597
E,2507454001214868
demencia25894540012156104185233286329350396
s30004540012139
Lewyho3056454001214794165213267320
telieskami.3391454001213279101123171208252299380401420
The3404810012455114167
genetics5274810012459112172225263291337382
of929481001245892
Alzheimer's1042481001246593141201254282369423462484527
disease1589481001246088132185239283336
and19464810012452111172
dementia21384810012459113200253313350378432
with25904810012476104141201
Lewy28114810012451105181236
bodies30674810012460119179207261305
The3404990012150106157
genetics5164990012156106162212246269313354
of889499001215584
neurodegenerative9934990012155106161193248305356412463518569602650683706754803
dementias18154990012157107191241297329352400439
is2274499001212362
a23554990012149
turbulent2425499001213388120177233256306362394
topic.2839499001213387144167212234
On30924990012169125
the3236499001213489139
one33944990012155111162
hand,35754990012155103159215236
the340513001213388138
number4955130012155110192249299332
of844513001215584
genes9455130012156106161211250
involved1213513001212378124177201249297354
in1585513001212378
the1680513001213388138
pathogenesis18355130012157105138192247303353408458497520559
of2411513001215584
neurodegenerative25125130012156106160193247303353410460515565597646678700748797
processes3327513001215689143188237276315365404
is3748513001212462
gradually340527001215688136192246294317340387
increasing,744527001212378123155204252291313368423444
on12055270012155110
the1333527001213387137
other1488527001215487141191224
hand,17295270012156103158214235
the1981527001213388138
problem2136527001215789143200224274357
of2510527001215583
interpretation2611527001212378110159191248281330363411444466521576
of3205527001215483
the3305527001213388138
results3460527001213382121175198231271
is3749527001212362
emerging.3405410012150134184217273296351407428
Alzheimer's788541001216285128183234257340391424443481
disease1290541001215780119170218257307
(AD)1617541001212989155181
and18195410012148103160
dementia19995410012157107190241297329352400
with2419541001217498131186
Lewy2625541001214797170221
bodies28665410012157113170193243283
(DLB)3169541001212994142196222
represent3411541001213383140173223262313368401
currently340555001214498130162210265296319365
well-defined7225550012173121144167198256305334359413463519
clinical125855500121446689143165209256279
entities.15545550012149104135158190212261300320
AD18915550012161126
has20335550012155102140
clearly2190555001214467116163195218264
defined24715550012156105134159213263319
causal2807555001214492145183231254
genes30785550012155104159208247
(APP,3341555001212933715550012156105153168
PSEN1,3553555001215095140200243259
PSEN2)3405690012151971422042515905690012128
and6425690012148103160
a8265690012148
major8955690012183131155210243
susceptibility1161569001214094134179228285318341397421444467500550
gene17355690012156106162212
(APOE).19715690012128200056900121571071742212225569001212847
In2295569001212480
addition23985690012148105162185218241296352
to2773569001213387
these,2884569001213388139178229248
new31565690012155106179
susceptibility335956900121399413317822728431734039742034058300121244780129
genes4965830012156106162212251
are774583001214880130
gradually930583001215689137194249297320343391
emerging13475830012150134184217273296351407
that1780583001213389137169
modify19755830012184139196219249299
the2301583001213388138
clinical246558300121456891147170214263287
picture,2778583001215780125160215248298317
the3122583001213388138
age32875830012148104154
of3467583001215584
onset35775830012155111150200234
and,3405970012148103160181
together545597001213387144194228283333366
with935597001217497131186
APOE,1145597001215710717422113655970012121
create1410597001214577127175207257
a16915970012148
complicated1760597001214599182239263286331379412461518
genetic23025970012156107162213246269314
background.26405970012157106151197252284339394449506527
Dementia31915970012167118201252307340363411
with3626597001217397130185
Lewy340611001214898172223
bodies5916110012158114172195246286
(DLB)905611001212995143198224
is1158611001212363
a12506110012148
more13206110012184139173223
heterogeneous15726110012155106140190223278336386443493550606645
entity22466110012150107139163196246
than2521611001213389137193
Alzheimer's2743611001216285128184235259343394427447486
disease,3250611001215780120171219259310330
both36096110012157113146202
clinically34062500121456892147171216265289312360
and7296250012148104161
genetically.9196250012156107163214247271316365389412460477
DLB14246250012167115169
susceptibility1622625001214095134180229287320343401424448471505555
genes22056250012157107164214254
are2488625001214881131
multiple26486250012184139163196219277301352
genes30286250012156107163214254
shared3311625001214095144176227284
with3624625001217498131187
Alzheimer`s340639001216286129186237261345396430456492
disease,854639001215781121172221260312332
Parkinson12156390012154102135182208264303360416
disease,1660639001215781120172221260312332
frontotemporal2021639001212963119175208263297347431489546579629652
dementia27026390012157108193245301334357406
(FTD)3137639001212977130198225
and33906390012149105163
other3582639001215589145196229
neurodegenerations.3406530012155106161194248306356413463519569602650683706761817856877
In1239653001212480
our13416530012155110143
paper,15066530012157106162213246262
we17916530012173123
aim1936653001214871154
to2113653001213387
summarize2222653001214094177260309341365407457
the2702653001213388138
genetic28636530012156106162212246269313
background31996530012157105150197251284338394449506
of3727653001215584
both3406670012157113145201
AD5656670012161127
and7176670012148103160
DLB,9016670012167114168189
to1114667001213387
characterize12256670012145100148181229274309359391415458508
their1757667001213388139162195
similarities1976667001214062146169192240272296329352402442
and24426670012148104160
differences,2627667001215679108141191224274330375424463484
and31366670012148103160
to3320667001213387
highlight3431667001215679135190214237292348380
the340681001213388139
complexity500681001214598182239263313360384417467
of988681001215584
the1093681001213489139
neurodegenerative12536810012156106161194249306356413463519569602651683706755804
ecosystem2078681001215096149189237276310360443
(„neurodegeneratome“).25426810012129672611681001215399151183235288333385431484530562612643694775820343368100121356684
Key3406970012461113164
words:5256970012475133171232276302
Alzheimer's848698001216185127183233257340390423443481
disease,1350698001215780119169217256307327
apolipoprotein16986980012148105161185208264320377410465498547571626
E,2345698001214970
dementia24366980012157107191241297329352400
with2857698001217498131186
Lewy3064698001214797170221
bodies.33066980012157112170193243283304
Úvod3407450014780142208279
Alzheimerova480762001095782126181232258338389424478526575
choroba1120762001094196151186240297346
a15317620010945
demencia16037620010952103184235290336361409
s3407760010936
Lewyho395776001094287154199250300
telieskami71577600109307597118163199242286362383
sú1118776001093685
dve1223776001095195139
najčastejšie1382776001095094116156200236267312333369390436
neurodegeneratívne18387760010950951452140748001093082136184237285337385417463494516562615663
demencie.28307480010952100179226279322344391411
Alzheimerova3269748001095679120172220243321369400452496542
choroba2140762001094090139169218270314
predstavuje2470762001095181125177212243287329379401446
približne2932762001095181102153175196234284330
503278762001094691
–33807620010945
603436762001094693
%35457620010971
všetkých36327620010943781241542140776001094287126175
demencií2331776001095095169214264304325345
a26927760010943
demencia2753776001095095170215264305325368
s31367760010936
Lewyho3190776001094287152197247296
telieskaDECLARATIONS:3502776001092973951151601952372814068257008648871301662142563043393604124625014570257008514
Declaration406827100874987120141179207245272292334376
of445827100874166
originality:45382710087406888131151193231252272299338358
The406828200853473109
manuscript418828200855791130168195227249266306329
is452828200851644
original45832820085386178117133172205222
and481628200853472112
has49392820085387299
not50502820085387699
been516128200853975110149
published532128200854078118135151178217252292
or406829300853862
submitted414529300852867108167184208234269310
elsewhere.44702930085355381117169209246269305320
Ethical406830600873764107127160198219
principles43013060087427090132165185229249288319
compliance:463530600873172134177198218256298331369388
The406831800853678116
authors420531800853475100142183208238
attest44643180085356087124154179
that466431800852465101126
their481131800852465103121146
study49783180085295596138173
was517331800855389118
approved531331800853477119144185220257300
by406832900854073
the41583290085236399
local42743290085165689124141
Ethical44323290085345898115147182199
Committee464832900854179139198215239265300337
and500132900853474114
is513232900851745
in519432900851656
compliance526632900853270130170188205239279311347
with40683400085537298140
human423634000854081143180221
studies44863400085285496139157195226
and474034000853577119
animal48883400085347695156193212
welfare512834000855391110133170196233
regulations53903400085236110414516420140683510085234080120148
of423635100853859
the43153510085236399
authors’44343510085347397136176200229244
institutions46983510085175684109126150189214231270310338
as505635100853462
well513835100855187105122
as528035100853362
with53613510085526994133
the55143510085236399
World406836200856099124142184
Medical427336200855795137154188224242
Association453536200854474104144178196231256273314355
Declaration491136200854785119136172196232257274315356
of528836200853961
Helsinki536936200854785103132150190225244
on406837300853878
Ethical41653730085345898115147182199
Principles43833730085376178117150167207225261290
for46913730085216084
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