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2025387111800294128253374499
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aplikované6502030013353115141166216275326379440495
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ústav,11162180013360103140193244261
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fakulta1818218001333386137197223258312
Masarykovy21532180013389142184238273328380438490545
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lékárna,946233001332680132186221282334357
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u22382330013360
sv.2322233001334397114
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v27202330013353
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5I.340249007833373248001332650
interní446248001332686121175210271296
klinika,766248001335178103163188239293316
Kardioangiologie,11052480013360113149210235295348409470495555581641703728783804
Lékařská19332480013352106157211246290341395
fakulta,2351248001333286136197222258311334
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centrum9422630013349100159192225283372
klinického133326300133527699157180226275326385443
výzkumu,17952630013352106153202260349406427
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u31102630013361
sv.3190263001334395110
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univerzita,49182630013361119142192244277324347380432452
Brno5389263001336093152210
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ústav,8692780013361103140193244261
Lékařská11532780013352106158212247291342395
fakulta,1572278001333285136197222258311334
Masarykova19292780013388141184237273328380438490542
univerzita,24952780013360121146198252288336362398451474
Brno2992278001336095156216
Cluster340329001215879132169201248279
headache6403290012155104150204250293346395
je1055329001212573
primární1149329001215787109190236267321342
bolest15113290012157111133181219251
hlavy1782329001215677123168216
patřící20193290012157104134165186229250
mezi22893290012184132174195
trigeminové250532900121336385139187269290343396441489
autonomní30143290012148101132184238291373426447
cefalgie.3482329001214592119166188242263311329
Její340343001213785107128
léčba482343001212472115170216
vychází712343001214897139191237279300
z10263430012143
empirických10853430012150132186208238260302347395437489
doporučení15883430012157110165218249302345392446467
a20683430012149
zahrnuje2134343001214290143173227280301349
akutní,2497343001214993146177231252270
preventivní2781343001215788135181228281312333379433454
a32493430012148
přemosťující3314343001215787135216269306339391413434476497
přístupy,340357001215686107143175227280324337
které690357001214780126156203
jsou906357001212561113165
doplňovány10853570012155107162183235287331377429472
neuromodulačními15703570012155102155184236316369423475496541583635655735756
metodami.23393570012182130161212266311391412430
Verapamil2782357001215599129175228274354375395
je3190357001212572
považován32753570012156109153199240291335381433
za3721357001214390
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lék812371001212372117
první946371001215687136191212
volby,11743710012149100122177221235
ačkoliv1426371001214891135187209230276
se1719371001214088
u18243710012155
cluster1896371001214566119156188235266
headache21793710012155104150204250293346395
jedná2590371001212573128182228
o28343710012155
off-label2906371001215583113140163209264313335
použití.32583710012156110164205226257278297
Léčba3572371001214794138192239
verapamilem340385001214895125172226273353374395444525
má8783850012184129
být10213850012157101135
zahájena1170385001214390143189210258312358
co1541385001214596
nejdříve16513850012155104125180210231277324
na19893850012155101
začátku2104385001214290132179209253306
clusterové2424385001214566118155187234265317362409
periody28463850012157106137158211266311
dávkou31713850012156102146191242295
2403480385001215197148
mg/36423850012183137169
den,3403990012156105158177
podmínkou5403990012157111166247268322366418471
je1034399001212473
vyloučení1130399001214896118172225268315368389
kontraindikací1542399001214799153183213260281334389410455502545566
a21303990012149
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elektrokardiografický2582399001215072120165199230282327375405459481534588619665692717759804852
nález.34573990012155101123171212232
Již371239900121375899
v3404130012148
prvním404413001215686134187208288
týdnu705413001213279132184236
léčby954413001212370113166210
je1177413001212471
pak12614130012156102146
dosažena14204130012156108144190230277330375
obvyklá18084130012154108153200245267312
účinná2133413001215597117169221266
dávka24124130012156101144189235
3602660413001215198147
mg/den.28204130012183136168217264317335
Další31694130012165110131167187
navyšování33694130012155100144192228280324370422442
probíhá340427001215788140195217272318
postupně6784270012157111148180233287341389
dle1087427001215678126
individuálních1232427001212477132153199221276328374396449470513566
potřeb18174270012157111142172220275
pacienta21114270012157104147168216270300347
a24774270012149
za2543427001214391
pravidelných2653427001215788134179201255304326379422464517
kontrol3190427001214798152182213265287
elektrokardiogramu.3497427001215072120166199230283340441001214795126181202256311342390472525544
Léčba909441001214896140195243
vysokou1176441001214998136190236288342
(≥1543441001212884
48016524410012151103153
mg/den)18304410012184139172223272326350
a22054410012148
velmi2271441001214896119200222
vysokou2518441001214897136189235288342
dávkou28844410012157104149195247301
(≥720mg/den)3210441001212884144193242335390424474523578601
verapamilu340455001214895126172226273354375396448
probíhá802455001215788140195216271317
pod11334550012157110165
dohledem13124550012156109163184232287335417
specialisty1742455001214094143186207253274295332364411
a21674550012148
souběžně2232455001214093146200249290343391
vyžaduje2637455001214896139186241293315363
kardiologické3014455001214694124178199252273326381402444489535
sledování.3563455001214061109164217340469001214895148169188
Maximální5454690012180127172194275321342395417
doporučená9794690012156109164218249302345392446492
dávka14884690012156102147192240
k17454690012146
preventivní1809469001215788135181228282312333379434455
léčbě2281469001212372115170218
cluster2516469001214566119156188236266
headache27994690012156104150205251294347395
je3211469001212573
96033014690012151101151
mg/den.34694690012184138171221269323342
Preventivní340483001215383131176223277308329375429450
léčba807483001212472116170217
probíhá1041483001215788141196217272318
několik13774830012155103149200222243288
týdnů1682483001213381135188241
až1940483001214889
měsíců20464830012184132170190233286
a23494830012148
ukončuje24144830012156100152206249301323371
se2802483001214088
postupně.29084830012157110148180232287341389406
Klíčová340500001246393121168227281336
slova:704500001244473133187241268
cluster1002500001214670126167202252286
headache,13185000012157109158216266312369421442
trigeminální178950000121346892150201287311368418442499523
autonomní23415000012149106140196253310395452476
cefalgie,2847500001214696127177202259284335356
management32335000012185134191241298350436488545579
bolesti,3405140012157113137187226260283304
terapie,665514001213382115164221244294314
blokátory1000514001215781137184233266320353403
kalciových1424514001214796120165187243290340384439
kanálů,1884514001214797152200223278299
verapamil.2204514001214897130178235284367390414434
Verapamil3405420012464113152205265318405433461
in821542001242787
the928542001243796150
preventative1098542001246099152204256316352406443472525577
treatment1695542001243776129183220307361420457
of2172542001245893
cluster2285542001244573132176214267306
headache26115420012459112166226280325385438
Cluster340556001235984141183219270306
Headache6665560012368120171229280325382434
Awareness11215560012364137188223275333384426468
Day16105560012368119167
202517985560012354107159212
Cluster340573001215881136176210259293
headache6615730012156107155212260305361411
is1101573001212363
a11925730012148
primary1262573001215790114197246278329
headache16205730012155106154211260305360411
disorder2059573001215780120175208265315348
classified2436573001214568116156195218248274325382
under28475730012155111168218251
trigeminal312757300121336690146196280304359407431
autonomic358657300121491041371913405870012155110193216260
cefalalgias.618587001214593123172195242266321344392431452
Its108758700121245797
treatment1202587001213365114162194277327383415
is1634587001212462
based17145870012157105144194251
on19835870012154110
empirical21105870012150133190213245268313361384
recommendations2512587001213382127181264347397452508556588611666721760
and32895870012148103160
includes3466587001212478123146200256306346
acute,340601001214893148181230250
preventative616601001215790139187236292324373406429477526
and11686010012148103160
bridging1353601001215790114171227250305361
treatment1740601001213365115163196279330385418
strategies,2183601001214074106155187237293317367406427
and26366010012148104160
complemented2822601001214598182239263313397447503535584642
by34896010012157104
neuromodulatory36186010012156106162340615001213387171226283338361409442496529579
methodes.9396150012183134167222277335385424446
Verapamil14046150012156103136184241290373396419
is1843615001212362
considered1925615001214598154193216273323356406463
first-line240861500121295587128162190214237293343
preventative2771615001215789139187236292324373405428477526
medication,33166150012184134192215260308341364419474495
although340629001214872105160215270326382
its74562900121235697
use865629001215595145
in1033629001212479
cluster1135629001214568123162196245278
headache14366290012156106154211259304359409
is1869629001212362
off-label.1955629001215484116145170218275326350371
The23496290012150106157
treatment2529629001213365115163196279330385418
should2970629001214095150205229285
be32786290012157108
started3410629001213973122154190240297
at3730629001214881
the340643001213388139
very499643001214897130181
beginning7006430012157108165188243298322377433
of1153643001215585
the1258643001213388139
cluster1417643001214568123162196245278
period17166430012157108141164219277
with2013643001217498131186
an22196430012149104
initial2343643001212479102135158206230
dose25936430012157112151201
of2815643001215584
2402920643001215199152
mg/day,30926430012184140175227275321337
prior3449643001215790114169202
it3671643001212457
is3748643001212463
mandatory3406570012182130184239286318371403453
to810657001213285
rule912657001213387110159
out10886570012154109141
contraindications1246657001214497152183215263285339395417461509541563617672710
and19736570012147102157
confirm2147657001214597152180206237320
that2484657001213286133165
patient´s26666570012156104136158207262294322355
echocardiographic3041657001215095149203247295327382404458514546593649704726770
finding340671001212955110166189244299
is657671001212362
normal.7366710012156110143226274297317
During10716710012166122154177232287
the1376671001213388138
first153167100121295587127161
week17096710012174123173220
of1947671001215483
treatment,2048671001213365114162194277327382414435
the2500671001213388138
typical2656671001213382139163207255279
effective2952671001215079112162207242265312361
therapeutic3331671001213387137170218274325380413435480
dose3406850012156112151201
of568685001215484
3607046850012152102154
mg/day8856850012183139174226274320
is1231685001212463
achieved.1320685001214893148171221269318375396
Further17436850012148101134170225275308
increase2077685001212479124156206254293344
of2447685001215584
the2558685001213388138
dose27236850012156111150201
is2950685001212463
provided3039685001215790145192216272322380
stepwise3445685001214074123180253277316366
according340699001214893137190223279303358414
the776699001213389139
needs9386990012155105156214253
of1214699001215484
the1320699001213388139
patient14816990012157106138161212267300
and18036990012148104160
with1986699001217397130185
routine2194699001213287142176199254304
electrocardiogram2521699001215074124170205238292338386419475498553610643691774
monitoring.33186990012183138194217250304337361416472493
If340713001212454
high415713001215579134190
(≥626713001212885
4807247130012151104156
mg/day)9017130012183139174227275320347
or1269713001215588
very1378713001214897130181
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doses17917130012156111151201241
(≥2053713001212885
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mg/day)23247130012183139174226274320347
of2692713001215584
verapamil2797713001214898130179236284367391414
are3232713001214881131
necessary,33847130012156106152201240279328361411427
treatment340727001213366115164196279330385418
should782727001214095150205229285
be10917270012157108
administered12237270012149105189212267290329363412445495552
under17997270012156111168218251
the2074727001213388139
specialist´s2237727001213996147193216263287310349383411446
supervision2704727001214094151202235286310349372427483
with3211727001217397130185
close3420727001214568124163213
cardiological3657727001214594126340741001215680135159214270294338387411
follow-up.770741001212984108131186259291347404424
The12137410012150106157
maximu13897410012184132179203286341
recommended1749741001213383128182266349399455512562619
dose23887410012156111150201
for2608741001212984117
preventative2745741001215790139187236292324373405429477526
treatment3290741001213366116164196280330386418
of3728741001215484
cluster340755001214568123162196245278
headache6367550012156106154211259304359409
is1063755001212463
96011447550012151103155
mg/day.13187550012183139174226274320336
Preventative1672755001215485135183232288320369401424473522
treatment2212755001213366115163196279330385418
usually2648755001215594149197220243291
continues2957755001214598154187210265319370409
for3384755001213085118
several3520755001213990137186219268291
weeks3407690012174123174221264
or625769001215588
months7347690012183138194227282321
and10767690012148103160
must12577690012184138178212
be14907690012157108
withdrawn1619769001217397130185242274323395451
gradually.2092769001215688137193248296319343390406
DECLARATIONS:4068332008648871301662142563043393604124625014569332008514
Declaration406834600874987120141179207245272292334376
of445834600874166
originality:45383460087406888131151193231252272299338358
The406835700853473109
manuscript418835700855891130168195227249266306329
is452835700851644
original45833570085386178117133172205222
and481635700853472112
has49393570085387299
not50503570085387699
been516135700853975110149
published532135700854078118135151178217252292
or406836800853862
submitted414536800852867108167184208234269310
elsewhere.44703680085355381117169209245269305320
Ethical406838200873764107127160198219
principles43013820087427090132165185229249288319
compliance:463538200873172134177198218256298331369388
The406839300853678116
authors420539300853475100142183208238
attest44643930085356087124154179
that466439300852465101126
their481139300852465103121146
study49783930085295596138173
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