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NEUROLOGIE3418040010757101158205267310370429450493
PRO856804001074591154
PRAXI1031804001074591148201221
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Neurol.1374804001075593139165209227243
praxi.1633804001074672114152170186
2025;26(1):68-711836804001074487128172185229272295335353367412457485525565
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681828020012657116
SDĚLENÍ341200012656130188244301376409
Z772200012659
PRAXE853200012660123195263321
Konopí34136001063372114155190207
jako5643600106226196135
lék7153600106296197
Konopí3409200298147279419556698763
jako1152920029870196324459
lék1659920029866192322
MUDr.3401320013793168245287311
Petra6731320013764120161204261
Mištríková9571320013793124172212255285346409465523
Neurologické3401480013372128188223283309369431456505556609
oddělení,9721480013361123185240266321381406429
Vojenská14241480013361117143198259301352406
nemocnice18531480013361116208268318378403452505
Brno2381148001336096157217
Konopí3401990012155110168225284309
seté680199001214092127178
(Cannabis885199001212984137192247300355379417
sativa)1329199001213791123147194246274
je1634199001212577
rostlina,1742199001213389130165190215272321344
která2117199001214785136170220
byla23681990012158106132181
do25801990012157114
19.2725199001215299118
století2874199001214075131157209244269
v31731990012149
Čechách32531990012159109157214263310367
i36511990012123
na37051990012156106
Moravě3402130012181139173224272323
zdrojem6942130012143102136192217270355
suroviny1080213001214197131187236262319366
pro1477213001215892149
výrobu16572130012149101136193252309
textilního1997213001213385134171196221278302361418
materiálu24462130012185135169220254280329354411
kanafasu.2888213001214798156205236287328384406
S33252130012150
rozvojem3406213001213390133186242267319405
výzkumu3402270012148100146194250334390
endokanabinoidního7602270012150106164220268319375424482506563619643701757781839895
systému1685227001213989129164214299355
se2069227001214091
tato2190227001213383116171
rostlina2391227001213288128163187211267316
dostává27372270012156113153188237285334
opět31012270012155113165199
do33302270012156112
popředí34722270012157114172206256315339
zájmu.340241001214394118203258280
Endokanabinoidní6422410012149105163219267317373422480505561617641699755779
systém1443241001214089130164215299
ovlivňuje17642410012155103128152201258314339390
homeostázu21762410012155111196247304344379429474530
celého2727241001214595120172228284
organismu3033241001215589146195251275315399455
na35102410012155104
bázi36362410012157106151175
modulace3402550012185143203260285336383434
aktivity806255001214998136161212237273325
jiných1162255001212550108156202260
neurotransmiterů,14532550012157110168202259294329380438479565590625677712770792
např.22772550012157107166201218
nocicepci,25272550012156114162187234285345393418440
kognici,29992550012148104163221246293318341
spasticitu,3371255001214099151192228253300325360418440
spánek340269001213997146202253301
aj.66126900121487395
Kanabinoidní7752690012154105161209267291347403427485541565
receptory1359269001213384130180238272326360411
se1790269001213991
nachází19002690012156105150206255299323
v22432690012148
periferním23112690012156108142166197248281338362446
(CB2)2777269001212884138189215
i30122690012123
centrálním3055269001214595151184218267291347371455
nervovém35302690012155106140192247340283001214898183
systému544283001214089130165215299355
(CB1),921283001212885139187209229
ale1171283001214873124
i13172830012123
v13622830012148
pojivových14312830012157114139163212267315367412468
tkáních1920283001213381131188212257313
a22552830012148
imunitním23242830012124108164220244278335359443
systému.2788283001214089130165215300355377
Nejznámějšími31872830012166117142186243292376427452492516600625
účinnými3402970012156103128185243291378403
molekulami7742970012185143169221271329354404490515
je1321297001212477
delta-9-tetrahydrokanabinol14292970012158111136171222256310346382433469503554612659718752809859910968101810771103116012181244
(THC)2704297001212984152213244
a29802970012149
kanabidiol3060297001214899157207267292351376434459
(CBD).3551297001212987142212240260
Prezentuji340311001215488140185237295330387412437
kazuistiku8083110012148100145202227269304329378436
pacienta12753110012158109156180233291325376
s16823110012140
chronickými17543110012145103137194252277323372425512537
vertebrogenními23223110012149100135173224283318375434487545602627713738
obtížemi30913110012156116151175221273359384
a35063110012149
polyneuropatií358731100121571161411913403250012155107163196251309359392416440
dolních8003250012156112137193217263319
končetin11383250012147102158204254288312368
doprovázenou15263250012156112170204259307357401452508564620
neuropatickou21663250012155107163196252310359392416462509564620
bolestí.28063250012157113138189230264288310
Léčebné3136325001214797144194251308359
konopí35153250012147101158214272297
v3403390012148
monoterapii4183390012184140197253287338372421479504528
nebo9763390012156108166223
kombinované12293390012147102187244269325382430480536587
terapii1847339001213383117167225249274
může21513390012183139183234
být24153390012157105142
dobrou25883390012156112171205261317
volbou29353390012148103129186243299
pro3265339001215791147
pacienty34423390012157107153177228285318369
při340353001215791115
léčbě478353001212475122179231
neuropatické7323530012156107164197253311361394418464511561
bolesti13163530012157114139190231266290
v16293530012148
individualizované1700353001212480137162211236293349398423447490546594644700751
léčbě.2475353001212375121179230251
Klíčová340369001246190118163220272325
slova:682369001244371129181234260
konopí,9603700012147100156211268291312
endokanabinoidní12903700012149105161216263312367415472495550605628685740763
systém,2071370001213987126160209292313
kanabinoidní2402370001214796151199255279334389412468523546
receptory,2966370001213382128177234266320353403419
THC,34033700012149115173195
CBD,36163700012158111178195
neuropatická3403840012155106161194248305354387410454501550
bolest.9113840012157113137187227261282
Cannabis3404110012460112172231284344372416
as776411001245397
medicine8934110012486140201229274303362415
Hemp3404290012164112192245
(Cannabis59842900121286214290012155103153203252301322355
sativa)98742900121368511313217522212054290012128
is1246429001212359
a13184290012147
herb13814290012155103133186
which15804290012173125146188239
was18324290012173118154
used1999429001215491138192
for2204429001212981111
the2328429001213284131
production2472429001215687138192243285318338390443
of2927429001215581
canvas3021429001214489142185230266
until33004290012155107136156177
the3490429001213284132
19th3635429001215092124176
century340443001214490142172223253300
in653443001212375
Bohemia7414430012153105158205285306350
and11044430012148100153
Moravia.12704430012179131161207250271316334
The16174430012149102149
progress1779443001215686138191221267304340
in2132443001212375
research2219443001213379116163208237279330
focused2562443001212981123175211258312
on28874430012154107
endocanabinoid30064430012150102155207250295347392446466518570591644
system3663443001213984120340457001213380161
brings514457001215787108161215251
this779457001213385106143
herb9354570012155103134188
into1137457001212376106157
the1308457001213385133
focus1455457001212981124176213
again.16824570012148101147167220239
Endocanabinoid19344570012149101156208251297350396450471524576597651
system2599457001213985122154200281
influences2894457001212376102126178226279322368405
homeostasis33134570012155108189237290327358404441462498
of340471001215582
the440471001213386134
whole5924710012173127180202251
organism860471001215586140186239260297378
due12564710012156109157
to1431471001213385
modulation15334710012184137192245266312343364417470
of2021471001215582
neurotransmiter21204710012156104158188241272302349402439520541572619650
activity2788471001214891124145191213244292
and30984710012148101156
subsequently3271471001214092147184233288341389443473494540
the340485001213386135
nociception,4994850012155108152173215262318349370423476495
cognition,1018485001214597151205226257278331385404
spasticity,1445485001214095141178210231274295326374388
sleep1857485001213961109158213
etc.2094485001215082123143
Cannabinoid22614850012158104157212259314337391445468523
receptors2810485001213382126174230263316348387
are3223485001214879128
situated337748500121406294148195226274331
in3734485001212377
the340499001213489139
peripheral5074990012157108141164221277328360409432
(CB2)966499001212985138188213
and12064990012149105162
central1395499001214594150182215263286
nervous17084990012157107140191245301340
system2075499001214088128161211295
(CB1),2397499001212985138185206224
as2648499001214988
well27634990012175124148171
as2961499001214988
in3076499001212479
the3182499001213489140
connective3349499001214599155210261307342364413462
tissue34051300121335492129182231
and5865130012148101156
immune7575130012124105186239293341
system.1114513001213985123156203285305
The14345130012149104153
best-known16025130012156106143176202249304357428482
effective2100513001214978109157201235257303351
molecules24665130012183136159207251304326375413
are2894513001214879127
delta-9-tetrahydrocanabinol30365130012156105127159206236286319350398430461508561605659690743340527001214592146193249271325379402
(THC)758527001212879144201229
and10035270012148102158
cannabidiol1176527001214593147201248303326381403457480
(CBD).1672527001212882134200225243
I19305270012124
present1974527001215688137175224279310
a23005270012148
case2367527001214592130179
report2562527001213381137192224259
of2836527001215583
a29355270012148
patient30025270012157104136158207261292
with3310527001217496128182
chronic3508527001214498130183237259303
vertebrogenic340541001214896127162210266297350406455509531574
problems930541001215788142197220269351389
and13355410012148102157
polyneuropathy15085410012156111134180235284338369422478525557610654
of2178541001215583
the2276541001213387136
lower2428541001212377149197228
extremities2672541001215096131162210292314346368417455
accompanied3143541001214891134186268323371425447495551
by37105410012157102
neuropathic3405550012155105159191244300348380434456500
pain.8575550012157104126181201
Medical10755550012180130186208252300322
cannabis1414555001214593147201248304327365
in1796555001212377
monotherapy18905550012184138192247278333382414461517562
or2469555001215587
in2573555001212478
combination2668555001214597180236258313360391413467522
therapy3207555001213387136168216271317
can3541555001214592147
be37055550012157106
a3405690012148
good4075690012156110165221
choice648569001214498152175219267
for934569001212983115
patients10685690012157105136158208262294333
with1420569001217497129183
neuropathic16225690012156105159191244301348380434456500
pain21415690012157105127181
in2341569001212378
individualized2438569001212377133155203225281335382404426468517573
treatment.3030569001213465114161192275324379410430
Key3405850012462114166
words:5365850012477137178241288316
hemp,8855860012156109196255277
endocanabinoid11955860012151109168226275326384435494520578636662721
system,1949586001214091133170222308332
cannabinoid2313586001214697155213264323349407465491550
receptors,2896586001213386134186246281338373416440
THC,33695860012150119180205
CBD,36065860012159115185205
neuropathic3406000012155108165200256315366401458483530
pain.8956000012157107133190213
Konopí3406470014770136205274344376
Konopí4806640010950101154206260283
je791664001092371
jednoletá890664001092270124177229252300332378
rostlina,1297664001093082119151174196249294315
o16406640010951
jejíž171966400109237194116157
taxonomii1905664001093077340678001094290141191267288309
se673678001093682
vedou779678001094388140190240
mezi10436780010975121161182
botaniky12496780010952102132176226248290336
spory.1609678001093587137167213228
Buď1862678001094898151
se340692001093785
uvádí459692001095197143197220
monotypický7136920010977130183235267315370393436481529
taxon1275692001093178123174227
konopí1536692001094495148200255278
seté1848692001093785117164
(Cannabis3407060010926364706001095096145194241289310343
sativa)7297060010934811091291712179447060010926
a9957060010944
jeho1064706001092268119169
poddruh12587060010952103155206236287337
konopí1620706001094392142193245266
indické1912706001092171340720001095275117161208
(Cannabis57672000109266017200010951100150200250299321356
sativa981720001093583113135178225
subs.1231720001093788142179200
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anebo1761720001094497144198251
polytypický3407340010951102124167200245297319360402448
taxon809734001093074117166216
zahrnující1047734001093883134163214263285306347368
Cannabis1436734001095096145193240288309342
sativa1796734001093481109129171216
a3407480010944
Cannabis411748001095199149199247296318353
indica786748001092271120142182230
nebo1042748001095198152204
tři127374800109306183
druhy:1383748001095283135187229250
Cannabis1660748001095199149199247296318353
sativa340762001093480109129170216
L.,5737620010940614762001091938
Cannabis672762001095096145193240288309342
indica1031762001092069116137175221
Lam.,12697620010940871601428762001091938
a14867620010943
Cannabis1549762001095096145193240288309342
ruderalis1908762001092876340776001094788118163184205238
Jan.5957760010932801287227760010919
Cannabis2280650001095199151202253304327363
sativa2670650001093485116139183232
je2933650001092271
původem30356500010952106153205261310389
ze3454650001094089
střední35736500010936701031512072140664001095073
Asie.2241664001095594117164184
Vyznačuje2453664001095196139191236279330354402
se2884664001093684
teplomilností,2997664001092976130155207285308332384436474507531552
světle3578664001093682129162185233
zelenými2140678001093886110157210253331354
listy251567800109214482114162
a26976780010943
dosahuje27616780010950102140186238290314361
až3143678001094384
632486780010946
metrů33146780010975123155187239
výšky.3573678001094391129174221238
Pěstuje2140692001094996135169223248297
se2468692001093686
nejčastěji25856920010951100125169216255290338363387
v30036920010944
Mexiku,30786920010974124170195240294317
Kolumbii,34266920010949102127180259314339364385
Thajsku,2140706001094497142166203247299320
Vietnamu2480706001095074122154206251328379
a28797060010943
Africe.2942706001095583115138181227247
Cannabis3210706001095097148198246296319353
indica3581706001092171120143183231
pochází21407200010953108154208256299325
z24977200010940
Himalájí,2570720001096086166214239287312337360
z29637200010939
oblasti30357200010951107133181221255280
Hindukúše,3348720001096086140196250297351391441463
roste2140734001093085125161210
ve2392734001094494
vyšších2527734001094595136176202247302
nadmořských28707340010952100157238293327369416467511566
výškách3478734001094495136183233278333
a21407480010944
k22157480010943
tomu2288748001093183162215
je2534748001092271
i26367480010921
přizpůsobená2688748001095285109151206260299352407457510557
svým3276748001093684133213
nízkým3520748001095074117162211291
vzrůstem2140762001094385117169206239285362
(dosahuje2522762001092575127164210262313337384
maximálně29267620010975120164188265310333385432
233787620010946
m)34467620010975100
a35667620010943
tmavými362976200109291061512140776001094391170193
listy.235877600109214482115162180
Konopí25627760010949100153205259283
obsahuje28697760010949104142188241293316364
více3258776001094367110157
než3439776001095098139
136027760010947
0003664776001094797147
DECLARATIONS:4068199008648871301662142563043393604124625014569199008514
Declaration406821300874987120141179207245272292334376
of445821300874166
originality:45382130087406888131151193231252272299338358
The406822400853473109
manuscript418822400855891130168195227249266306329
is452822400851644
original45832240085386178117133172205222
and481622400853472112
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been516122400853975110149
published532122400854078118135151178217252292
or406823500853862
submitted414523500852867108167184208234269310
elsewhere.44702350085355381117169209245269305320
Ethical406824900873764107127160198219
principles43012490087427090132165185229249288319
compliance:463524900873172134177198218256298331369388
The406826000853678116
authors420526000853475100142183208238
attest44642600085356087124154179
that466426000852465101126
their481126000852465103121146
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by406827100854073
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Committee464827100854179139198215239265300337
and500127100853474114
is513227100851745
in519427100851656
compliance526627100853270130170188205239279311347
with40682820085537298139
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studies44852820085285596139157195226
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welfare512628200855391110133170195233
regulations53872820085246110414616420140682930085234080120148
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authors’44342930085347397136176200229244
institutions46982930085175684109126150189214231270310338
as505629300853462
well513829300855187105122
as528029300853362
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World406830400856099124142184
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Association453530400854474104144178196231256273314355
Declaration491130400854785119136172196232257274315356
of528830400853961
Helsinki536930400854785103132150190225244
on406831500853878
Ethical41653150085345898115147182199
Principles43833150085376178117150167207225261290
for46913150085216084
Medical479431500855693134151183218235
Research504831500853874102139173197229268
Involving53353150085165690128146181198238278
Human406832600854685145179219
Subjects430732600853474114132168201227256
adopted458332600853474114155179215256
by485932600853973
the49523260085236399
18th507132600853669514132600501437
WMA5198326008559116160
General537832600854582122158182217235
Assembly406833700854475105143204247266302
in439333700851758
Helsinki,447433700854785104134152193228248264
Finland,47613370085355394113149190232249
in503333700851758
June511533700852668109147
1964,528533700853771110150166
with54753370085537197138
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amendments,443734800853493129169210269305345369398414
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