www.neurologiepropraxi.cz / Neurol. praxi. 2025;26(2):135-141 / 2025;26(2):135-141 / NEUROLOGIE PRO PRAXI 141 PŘEHLEDOVÉ ČLÁNKY Prodromální Parkinsonova nemoc – posun diagnózy před vznik motorických příznaků 29. Postuma RB, Iranzo A, Hu M, et al. Risk and predictors of dementia and parkinsonism in idiopathic REM sleep behaviour disorder: a multicentre study. Brain. 2019;142(3):744-759. https://doi.org/10.1093/brain/awz030. 30. Rusz J, Hlavnicka J, Novotny M, et al. Speech Biomarkers in Rapid Eye Movement Sleep Behavior Disorder and Parkinson Disease. Ann Neurol. 2021;90(1):62-75. https://doi. org/10.1002/ana.26085. 31. Seibler P, Streubel-Gallasch L, Klein C. Combining Biomarkers with Genetics In Prodromal/Earliest Phase Parkinson's Disease. J Parkinsons Dis. 2024;14(s2):S345-S351. https:// doi.org/10.3233/JPD-240155. 32. Schaeffer E, Yilmaz R, St Louis EK, et al. Ethical Considerations for Identifying Individuals in the Prodromal/Early Phase of Parkinson's Disease: A Narrative Review. J Parkinsons Dis. 2024;14(s2):S307-S319. https://doi.org/10.3233/JPD-230428. 33. Schalkamp AK, Peall KJ, Harrison NA, et al. Wearable movement-tracking data identify Parkinson's disease years before clinical diagnosis. Nat Med. 2023;29(8):2048-2056. https:// doi.org/10.1038/s41591-023-02440-2. 34. Siderowf A, Concha-Marambio L, Lafontant DE, et al. Assessment of heterogeneity among participants in the Parkinson's Progression Markers Initiative cohort using alpha-synuclein seed amplification: a cross-sectional study. Lancet Neurol. 2023;22(5):407-417. https://doi.org/10.1016/ S1474-4422(23)00109-6. 35. Simuni T, Chahine LM, Poston K, et al. A biological definition of neuronal alpha-synuclein disease: towards an integrated staging system for research. Lancet Neurol. 2024;23(2):178-190. https://doi.org/10.1016/S14744422(23)00405-2. 36. Singer W, Berini SE, Sandroni P, et al. Pure autonomic failure: Predictors of conversion to clinical CNS involvement. Neurology. 2017;88(12):1129-1136. https://doi.org/10.1212/ WNL.0000000000003737. 37. Sixel-Doring F, Muntean ML, Petersone D, et al. The Increasing Prevalence of REM Sleep Behavior Disorder with Parkinson's Disease Progression: A Polysomnography-Supported Study. Mov Disord Clin Pract. 2023;10(12):1769-1776. https://doi.org/10.1002/mdc3.13908. 38. Yoo HS, Chung SJ, Lee YH, et al. Olfactory anosognosia is a predictor of cognitive decline and dementia conversion in Parkinson's disease. J Neurol. 2019;266(7):1601-1610. https:// doi.org/10.1007/s00415-019-09297-x. 39. Zitser J, During EH, Chiaro G, et al. Autonomic impairment as a potential biomarker in idiopathic REM-sleep-behavior disorder. Auton Neurosci. 2019;220:102553. https://doi. org/10.1016/j.autneu.2019.05.005 . ODBORNÝ GARANT: prof. MUDr. Eva Kubala Havrdová, CSc. Neurologická klinika 1. LF UK a VFN v Praze POŘADATEL: SOLEN, s. r. o., ve spolupráci s Neurologickou klinikou 1. LF UK a VFN v Praze ZLATÝ PARTNER POČET KREDITŮ 2 Registrace ZDARMA TERMÍN duben 2025 až březen 2026 dostupný na online.solen.cz ON LINE KURZ OBSAH KURZU Revidovaná McDonaldova kritéria 2024 – doc. MUDr. Jana Lízrová Preiningerová, Ph.D. Význam sběru dat z klinické praxe – real-world evidence – zaměřeno na bezpečnost – prof. Helmut Butzkueven, MBBS, FRACP, PhD Perorální kladribin – nová data z observačních studií prezentovaná na kongrese ECTRIMS 2024 – doc. MUDr. Pavel Hradílek, Ph.D. Jak sbíráme data v České republice – národní registr ReMuS prof. MUDr. Dana Horáková, Ph.D. On-line kurz pro praktické neurology 1 2025
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