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přesnější947118001095385133172225273297336359
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stadiu.501188001093566110160182230250
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dva1111188001095094137
aspekty1265188001094278128174217249294
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prodromální340202001095385138193225277357404427480504
PN8742020010949111
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eticky1212202001094679102146191239
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kdy1455216001094293136
dojde16092160010950101123175221
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zkušeností760342001093983135173220272324362394417
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osob1513342001095088140193
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riziku180034200109305393116160212
PN3403560010948108
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pacientů1467370001095297138160207258289340
chce1834370001094091133178
znát214062001093992138170
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o2769620010951
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například293990001095196150182205251275321375
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RBD3648900010950102165
při2140104001095181103
polysomnografickém22611040010951102124167204254330380431482513557584608649692737812
vyšetření3091104001094389125172202232278329350
indikovaném34591040010921711231451872362803242140118001095097173
pro2335118001095283133
syndrom2490118001093681133185215266342
spánkové2855118001093588133184227277320366
apnoe.3243118001094496147198245265
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z21401320010939
možných21991320010975126166217259300351
řešení2569132001092975112159210232
je2820132001092269
informovat290813200109217299150181258309352397428
pacienta,3355132001095196138160206258288333354
že3728132001093885
dané2140146001095195146193
vyšetření2352146001094390126173204235281332354
může27251460010975125165212
přinést2955146001095182105156202239271
tento3244146001093076127158207
náhodný3470146001095095146196249300342
nález.2140160001095094116162201222
Dalším23801600010959103125161183258
principem2656160001095181103154195216268315391
je3064160001092268
non-maleficence,31491600010950100151181257302324370397422463508558600645663
který2140174001094275121151198
v23561740010943
tomto2419174001093080156186236
případě2672174001095282104156201253300
znamená2989174001093990134210256307352
zhodnocení3358174001093990140193244294336381433454
psychologického2140188001095289134175226278301353405428470513559611663
dopadu28301880010952103156202255306
sdělení3163188001093689136159206258281
rizika347118800109305393116159206
PN37041880010948108
a21402020010943
také2204202001093075119164
kapacity2388202001094388140186227249280326
zdravotního2735202001093890121166209259289341363415466
systému3222202001093580117148194271321
na3564202001095094
poskytnutí367820200109521032140216001093679125159210261292314
podpory24762160010952103156208260291337
osobě2836216001094986137189236
v30952160010943
riziku.315921600109295292114157208228
Sdělení3410216001094497143166212264286
by3718216001095295
měl21402300010975122145
předat2307230001095282128181226256
zdravotník,2586230001093991121166209259290341363408430
který3039230001094376122153199
má32612300010975120
zkušenosti3404230001093882133169216267318355386408
s21402440010935
interpretací2195244001092171101146176228258304334379420441
všech2653244001094379125166216
použitých28862440010951102152191213243289329379
testů,3282244001092974110141191211
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by2140258001095193
měl22512580010974120143
sledovat2411258001093557103155205249293323
reakce2751258001093075119162202247
pacienta3015258001095195136158204254284329
na3361258001095094
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informace2354272001092273100151182260304346392
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případně2838272001095283105158203256307354
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sdělení3534272001093588135158205256279
do2140286001095099
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návštěv2588286001094992134170200245287
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et3287286001094475
al.,337828600109436484103
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Je3734286001093378
třeba2140300001093060105157202
také2359300001093074117162
vzít2538300001094384106137
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úvahu,2755300001095094138189239258
že3031300001093883
v31323000010943
běžně3195300001095197137188234
dostupné34463000010950101137168218270321367
literatuře214031400109214374120150195226276307353
je2511314001092168
řada2597314001092974126171
informací278631400109217299149180257301343365
o31693140010949
prodromálních3239314001095182132185215265342386409459481523573
příznacích2140328001095283105146197242284307348400
neurodegenerativních2567328001095198149180231284331384431483530561607638660705757780822873
onemocnění346732800109501021492262783212140342001095097149171
včetně2339342001094384130161213260
PN,26263420010949108129
které2783342001094276122153200
si3010342001093658
pacient3096342001095197139161208259290
může34143420010975126166213
sám3654342001093682158
najít,2140356001095094116138169189
což2347356001094090129
může24933560010975125165211
mít2722356001097496127
v28673560010943
důsledku29313560010950100137159205257300351
negativní3300356001095096148193223245289341363
vliv368035600109436688132
na2140370001095094
vztah2261370001094485119164215
s25033700010935
lékařem,2559370001092168112157188234310330
který2916370001094276122152199
neinformoval3142370001095096119170197248279355406450495517
pacienta3686370001095196394062001094062109160191236
v4194620010944
riziku42586200109305292114158209
PN.4485620010948108128
V4632620010950
tomto470362001093080156187237
ohledu4958620010950101124170223273
je525062001092268
výhodnější,533762001094390142193245394076001095097119156178198
pokud4165760010951102146197250
je444276001092268
pacientovi453776001095196138160206258288338382405
informace49697600109217299150181257302343389
citlivě53857600109406293115137182227
podána3940900010951102154197248291
ošetřujícím424990001094984130161191241263285326347423
lékařem468990001092167110155185230305
s5012900010935
možností5067900010974125163214264300331352
klást543790001094165108144175
doplňující39401040010952103157181233284307330372395
otázky.4363104001095082128169214261278
Sdělení4669104001094598146169217269292
prognózy4989104001095284135189241293332380
může53971040010976127168215
přinést3940118001095283106158205242275
pro4243118001095183134
pacienta4405118001095297140162209261292338
i47711180010921
benefity:48141180010952100152199228253284331352
pravidelné5194118001095283129173196249296319371418
sledování3940132001093658104157208252297348370
a43361320010943
případně4400132001095182104157202254305352
časné4778132001094085122172219
zahájení5023132001093985136180203249301323
symptomatické53721320010935801572093940146001093079155199229251292335380
léčby4337146001092268110161204
PN45591460010947106
při4682146001095182104
objevení48041460010949101123169213258309331
se5153146001093581
parkinsonismu,52521460010951951261691922432793293940160001095072108184235255
podpora42181600010952103156208260291336
pro4577160001095182132
změnu47331600010938114161212263
životního5019160001093961106155186237259312363
stylu,5405160001093668114137187207
zejména3940174001093884106182228279323
zařazení4280174001093984114158198244295317
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pohybové50391740010951102153195247298341386
aktivity,5443174001094385119140394018800109436697143159
která4119188001094276122152197
má43371880010975119
potenciálně44771880010951102133179230272294338361412458
neuroprotektivní4956188001094996147178228281312362393439482516538583634656
účinky,3940202001094990111162204250265
symptomatická4223202001093579155206237286361405435457498540585
léčba4825202001092167109160204
prodromálních5047202001095081130182212262337381403453475515566
příznaků3940216001095182104144195240283334
a42972160010943
účast4361216001094991136173204
ve4588216001094388
výzkumu.4699216001094390132175226302353373
Lze5094216001094385131
očekávat,5247216001095092137181227270315345365
že3940230001093883
v40412300010942
blízké410323000109517395134177221
budoucnosti43412300010951101153203253294344394430461482
bude48402300010951101153198
přibývat5056230001095080102153196242287316
klinických5390230001094164861361571983940244001094289130180
studií4146244001093667118170192214
u43862440010950
prodromální4457244001095182132185215266342387409460482
PN49652440010948107
s50972440010936
potenciálně51542440010951103134179231272294339361412458
neuroprotektivními3940258001095097148178228281312363393439483516538583635657733755
metodami.47182580010975122153203256300376398418
Pro5159258001094878128
výzkum5309258001094491132176227303
nových39402720010950101145191232283
možností42492720010975126165216267304335357
léčby4632272001092168110162205
bude48632720010952103155201
stěžejní5090272001093668113153200222273295
identifikace5411272001092173120171394028600109315482108153200243290
osob4259286001095188141196
v44832860010945
riziku455028600109305495118163216
PN47952860010949110
v49332860010945
populaci50002860010953106160213237283326349
a53772860010945
validace54442860010945911151373940300001095298141188
biologických4157300001095376129153205260283326370419461514
diagnostických4699300001095276122175228280318351375418462511553605
kritérií.5333300001094377100132180212235259279
Závěrem3940314001095197142188220267346
lze4314314001092263110
shrnout,4452314001093789120173226278310331
že4811314001094087
prodromální4926314001095384136190222274352398421473496
fáze5450314001092774115163
PN39403280010949109
má40773280010976121
v42263280010944
současné4292328001093688140183228266318365
době46853280010952103157205
hlavně4918328001095174119163216263
výzkumný5209328001094492135179231309361404
význam.3940342001094390132183228304324
Je4287342001093380
však4389342001094480126169
pravděpodobné,4581342001095182127170221267320371424475528579626645
že5249342001093884
do53563420010951102
budoucna5480342001095110339403560010952104156199252297
bude42663560010952104158206
klíčem450035600109436890133179258
ke4786356001094389
kauzální4904356001094390141182230253305328
léčbě5260356001092270113167215
PN55033560010949110
a39403700010943
dalších4004370001095196118154176218269
α-synukleinopatií.4293370001095080117162213264307331378400451502555600630652674694
LITERATURA341393001234978134189250318368438498567
1.34041000853648
Arnaldi40841000834162101133149187203
D,63041000834556
Chincarini7064100083397792130162195216232270285
A,101041000834156
Hu108541000834482
MT,11864100083558897
et130241000833457
al.13784100083324760
Dopaminergic145741000834684124157215230268303324362377409
imaging1886410008314721043404200083395593133
and49542000833271111
clinical6274200083324864102118151185201
predictors8494200083396296137153186210248271299
for11694200083195780
phenoconversion127042000833979115154193227264304336371393421437476515
of180642000833858
REM188542000833671127
sleep3404300083264176112151
behaviour50843000833874112144176192230268289
disorder.8144300083385379117139177212233243
Brain.107443000833454881031391213430008312
2021;144(1):278-287.124243000833468101133141171202239258290304316352384418441472505538544
https://18034300083385984123150162189209
doi.org/10.1093/brain/awaa365.3404400083387692105143164203229262293306337368403436460500522555570608634664715748780815849883895
2.34045000853652
Behnke41445000833672110149180214
S,64945000833346
Runkel71645000833674113144178194
A,93145000834256
Kassar10084500083357097124158179
HA,120845000834587101
et133045000833457
al.14084500083324861
Long-term149045000833270109149171194229250310
course182045000833270108130158193
of34046000833757
substantia41546000832663102129152185223244260292
nigra7254600083375291112145
hyperechogenicity88846000833868108144165199232270308348382421436468483505539
in144546000831452
Parkinson's15154600083356788119135173200238276288313
disease.184446000833853791141463404700083266274
Mov43547000835390120
Disord.5724700083446084119140175746470008312
2013;28(4):455-459.77947000833569101132143179213232266283295330363396419456489522533
https://doi.org/10.1002/13334700083385984124151164191212248287302315354376415441475506519550582619652679
mds.25193.34048000835796123136172207238268301314
3.34049000853651
Berg4044900083357192130
D,54749000834556
Behnke61749000833570108146176210
S,84149000833245
Seppi89949000833368107146162
K,107449000833550
et113749000833456
al.12064900083324861
Enlarged12804900083327086118139177212251
hyperechogenic154549000833768108143165199231269308347382420435467
substantia34050000832663102129152185223245260292
nigra6465000083375291112145
as80550000833258
a877500008332
risk924500008321366292
marker103050000835790111141176197
for12405000083195678
Parkinson's13325000083356788118135173199237276287313
disease.16605000083385380115146173208220
Mov189450000835389119
Disord.3405100083435881116136170509510008312
2013;28(2):216-219.5335100083346798128139173206224258275287321352382405435466496506
https://doi.org/10.1002/mds.25192.10515100083375882121147159185205240277292305342363401426458489501531562598630656711749775788823858888917950962
4.34052000853550
Berg4025200083356989126
D,54052000834455
Postuma6065200083357096118155212243
RB,8615200083347082
Adler9555200083407791125146
CH,11125200083408395
et121952000833354
al.12855200083314658
MDS135552000835498130
research14975200083205379113143164194231
criteria1739520008331516688121141156187
for19385200083185475
prodromal3405300083396097136158195253285300
Parkinson's6535300083356788118135172198237275286312
disease.9805300083385379114146172207219
Mov121253000835388118
Disord.134153000834359821171381721512530008312
2015;30(12):16001611.1537530008334681001301401752092292602903083203493804164523405400083346596123133
https://doi.org/10.1002/mds.26431.4885400083375983123150162189209245283299312350371409436469500513543575611644671727766792806842875912944975985
5.34055000853651
Boesveldt41255000833674110137171206221261283
S,71655000833346
Postma78255000833673100123182215
EM,101755000833389102
Boak114055000833674108138
D,129955000834557
et137655000833457
al.14545500083324760
Anosmia153555000834180118145203219251
–1807550008335
A1863550008341
Clinical192055000834055703405600083385487120136
Review.49856000833671105121156209220
Chem73956000833876107164
Senses.920560008332621001241551801101560008312
2017;42(7):513-523.113556000833469102132142178211229265285297334366396419454488523536
https://doi.16935600083386085125153166194215251290306320
org/10.1093/chemse/bjx025.3405700083375997123156188200231262298330355383421456514541576602642657689724757792804
6.34058000853651
Dauvilliers40458000834577114147162177192207241262289
Y,70658000833543
Schenck76258000833264102136174206236
CH,10115800083398396
Postuma11205800083357197120158215247
RB,13805800083357184
et147758000833355
al.15455800083324760
REM161758000833569124
sleep17535800083264176111150
behaviour19165800083387334059000833870101117155193214
disorder.5685900083385379118139177212233244
Nat8265900083437999
Rev9375900083346494
Dis10425900083446083
Primers.113659000833453681241541752001335590008312
2018;4(1):19.136159000833468100131143178197229243255285315326
https://doi.17015900083375983123149162189209245283298311
org/10.1038/s41572-018-0016-5.3406000083375997123156188200231262296330355380416446476509544564601633664687724760792823846880892
7.34061000853746
Doty40761000834686109143
RL,5716100083377084
Shaman67661000833372106165198237
P,93561000833540
Dann99761000834679118157
M.117561000835670
Development126761000834682115151167206247306342382404
of169261000833858
the17716100083226298
University189061000834583993406200083326687114129152185
of54662000833756
Pennsylvania62362000833568106144171203219252284322338370
Smell101362000833290125140156
Identification11896200083155489127148164181198230263285300338377
Test:15866200083326390113127
a1733620008332
standardized178062000832649821201591922133406300083395484119159
microencapsulated52063000835873106128166202241274307347374412428461483517558
test10996300083225683107
of122763000833858
olfactory13066300083375473107140165202225259
function.15866300083195897130154170209248262
Physiol186963000833470991243406400083155166
Behav.42364000833465102138169588640008312
1984;32(3):489-502.62164000833565101137149185218236270287299334370405429463498531544
https://doi.org/10.1016/00319384(84)90269-5.1186640008338608412415116419121224828730231635437641544147550751955158261564667270674377680734065000833467101138157191227245279314347381415438472484
8.34066000853652
Dušek40966000834584110145175
P,60166000833540
Bezdíček65766000833671100139154185219249
O,92366000834758
Brožová9986600083355794122160192224
H,123966000834457
et131366000833456
al.13866600083324760
Clinical14636600083405570108123155188203
characteristics168366000833169102123156188212246267283309340670008322376997
of45467000833756
newly52867000833772123139171
dia7166700083385385
gnosed81867000833977115142177216
Parkinson’s10516700083356788119135173200238276288313
disease13806700083385379114146173208
patients16056700083387193108143181203230
included1853670008314528410013734068000833873112
in46568000831553
the5316800083216095
longitudinal6396800083145391130145167205244259297330345
BIO-PD9976800083355199122159204
study.12146800083264987126158168
Ceska13956800083386791120155
a1560680008336
Slovenska16086800083314580110139176200228263
Neurologie1882680008342731093406900083205570106142157187
a543690008336
Neurochirurgie.59169000834373110130165195232246267303323358372403994690008312
2020;83/116(6):633-639.102669000833469101136148184218242275303334353386404416452485518540577611644655
https://doi.17016900083386084123150163189210245284299312
org/10.48095/cccsnn2020633.3407000083375997123156188200235271306341375399428459490517555593627661694728764798831843
9.34071000853649
Fearnley4027100083326698119157172207238
JM,6537100083247992
Lees75871000833165100127
AJ.8987100083416780
Ageing99171000834079113128166205
and120971000833169108
Parkinson's13307100083356687118134172198236274285311
disease:16567100083385379113145171206219
substantia1887710008326631023407200083264982120142157189
nigra5477200083375291112145
regional7107200083215594109147186218234
selectivity.9617200083266177112145169184217232255288298
Brain.127772000833454881031391416720008312
1991;114(144672000833464100132140170198229248
Pt171272000833559
5):22832301.1788720008335536510013516820234073000833469103135145
https://doi.org/10.1093/brain/114.5.2283.500730008337598312315016218920924528329931235037140943546950051354357561064366770772976277781584187490293394598099210281063109711311143
10.3407400085367085
Fereshtehnejad4427400083326688122148186208242280318353368400439
SM,89874000833287100
Yao101574000833565103
C,113474000834053
Pelletier1204740008335698499134157172206228
A,144874000834156
et152074000833457
al.15937400083324760
Evolution167074000833364102118155178193231270
of195674000833857
prodromal3407500083396097137158195253286301
Parkinson's6547500083356788118135173199237275287312
disease9827500083385379114146172207
and120275000833270109
dementia132475000833873130165203225240272
with16097500083506688127
Lewy174975000833165116150
bodies:1912750008339773407600083385286112124
a476760008332
prospective5227600083385995121159194226249264296329
study.8647600083254885123154164
Brain.104076000833353861011361175760008312
2019;142(7):2051-2067.11997600083346798127140169199231248282301312346380413443461491525559592597
https://18087600083375882120147158185204
doi.org/10.1093/brain/awz111.3407700083387692105143164203229262293306337368403436460500522555570608634664715746777805833842
11.21404100085366678
Gibbons22344100083445998138177215241
CH,24914100083408497
Levine26044100083316598113151186
T,280641000833342
Adler28634100083418095130151
C,303041000834052
et309841000833456
al.31704100083324760
Skin32464100083326279117
Biopsy33784100083365189129155188
Detection358241000834580102136169193208214042000833776
of223642000833756
Phosphorylated231242000833572111137176215253275309325357379412452
alpha-Synuclein27844200083324786124157179211240279317349364399414452
in325642000831552
Patients33284200083356789104139177199226
With35744200083587496134
Synucleinopathies.372842000833362214043000833876108124159174212251291324346385400435462476
JAMA.2637430008324611151542792430008312
2024;331(15):1298-1306.282543000833469102134146181215246261293323342354384414449484507538568603639653
https://doi.34984300083386084124151164191212248286302315
org/10.1001/jama.2024.0792.21404400083375997123156188200231262299330352368400458491504540574607639651686719752785798
12.21404500085366884
Heinzel22424500083447994132161196211
S,247145000833245
Berg25344500083357092130
D,268145000834657
Gasser275545000834477103130165186
T,295945000833241
et301845000833456
al.30924500083324760
Update317045000834382122154176210
of339745000833857
the34724500083215994
MDS3584450008355101133
research37354500083215521404600083266193114144182
criteria2335460008331526890124145160192
for25404600083185677
prodromal26304600083386097136157194252284300
Parkinson's29434600083356687118134172198236274285311
disease.32694600083385379114145172207219
Mov350146000835388118
Disord.363046000834359821171381723800460008312
2019;34(10):1464-1470.214047000833468100130143178213233265296314326356387423460483514545577610622
https://doi.org/10.1002/mds.27802.27784700083375983122149162189209245283298311349371409435468500512543575611644670726766792805841874908943976989
13.21404800085366883
Hoglinger223848000834482122137152190229264285
GU,25384800083448899
Adler26524800083407994129150
CH,28174800083408497
Berg29294800083357192130
D,307448000834556
et314548000833456
al.32164800083324760
A3291480008341
biological33484800083385492108146185200232265281
classification364448000833146781051311462140490008317346699121136174212
of236849000833756
Parkinson's24404900083356788118135173199237276287313
disease:27684900083385380115146173208220
the30044900083216095
SynNeurGe311449000833362101146181219240286321
research34514900083205481116148169200238
diagnostic37054900083385385214050000833876114140163178210
criteria.2363500008331526890123144160192205
Lancet258150000832964100130158179
Neurol.2771500008343731091291641792948500008312
2024;23(2):191-204.297350000833468100132144179213231265282294324354386404435469505517
https://doi.35035000083375983122149161188208243281297309
org/10.1016/S1474-4422(23)00404-0.2140510008337599712315618820023126229432535038341444547750853156760463767168972375877581084688291895497710151027
14.21405200085366984
Hummel224452000834482140198233248
T,251252000833342
Sekinger25745200083326797114152191226247
B,284152000833548
Wolf290952000835794110129
SR,30585200083326781
et315952000833457
al.32365200083314760
'Sniffin'3316520008312468499117135153191202
sticks':3538520008326496597127156168179
olfactory37375200083375321405300083185284108145167201
performance23615300083387495117154176234267305337370
assessed27525300083315884119146173208247
by301953000833970
the31095300083226095
combined322453000833269127166182219254294
testing35385300083225582105121159198
of375653000833756
odor214054000833777115137
identification,22945400083145388126148163181198230263284300338376389
odor270054000833777115137
discrimination28545400083385379112133148206221259291313328366405
and327654000833270109
olfactory34025400083385373106138162199221255
threshold.36745400083226081115214055000832663101117155168
Chem232155000833773103159
Senses.249055000833160971201491742664550008312
1997;22(1):39-52.26895500083346398131140175209226258272283318351374408441453
https://doi.org/10.1093/31545500083385983122148161187207242280295308346367405430463494506537568603635659
chemse/22.1.39.214056000833169104162188223250285319332363372407441452
15.21405700085366883
Jacobs22415700083245688125165192
BM,245057000833691104
Belete25725700083357186121143177
D,276757000834556
Bestwick28415700083357097120173189221251
J,311057000832436
et316457000833456
al.32385700083314760
Parkinson's33165700083356788118135173199237276287313
disease36445700083385379114146214058000832762
determinants,22235800083397598132154214229268301340362390404
prediction26485800083396296137152185210226265304
and297358000833271111
gene-environment310558000833975113149173210249281298319357397456491530552
interactions3679580008314537511021405900083215589114130169208236
in239759000831554
the24735900083226198
UK259259000834581
Biobank.26955900083365291132166205237252
J2969590008324
Neurol301159000834475113134170185
Neurosurg321459000834475112134170194230252287
Psychiatry.351959000833459891201571732092312522843800590008312
2020;91(10):1046-1054.214060000833570104139153189223238271304323335366399436473498529562597634647
https://doi.org/10.1136/jnnp-2020323646.28086000083386186127154168195217253293309323362384424451485517531562591622658684700740779819843875911945980214061000833467101136172209222
16.21406200085366985
Jennings22446200083245997135150188227253
D,251662000834556
Siderowf25916200083324786120142179230251
A,286162000834155
Stern29346200083335488109148
M,310062000835568
et318662000833457
al.32616200083324760
Imaging334062000831572105144159197236
prodromal35946200083396098137158196214063000835890106
Parkinson22676300083356789120136175201240279
disease:25676300083385380115147174210222
the28106300083226096
Parkinson29276300083356789120136174201240279
Associated32266300083427097135168184216238272312
Risk35596300083365178108
Syndrome36886300083326310221406400083386097156192
Study.23526400083335493132165175
Neurology.2544640008343741101311661812172542842825640008312
2014;83(19):1739-1746.285864000833469101132144180214233265295313326356385420453477509538569605619
https://doi.34986400083375984124151163191211247286302315
org/10.1212/WNL.0000000000000960.214065000833759971231561882002312612923223494104554875015365726086456817177537898258618979339701005104010761088
17.21406600085366876
Jia22346600083243971
F,232266000833339
Fellner2378660008332668297135170191
A,258666000834155
Kumar265866000833572130162183
KR.28586600083357287
Monogenic296266000835493131170209244282297329
Parkinson's33086600083356788119135173200238276287313
Disease:3637660008345618712215421406700083276376
Genotype,223767000834581121160183218259295308
Phenotype,256667000833675111150189212247288325337
Pathophysiology,29256700083356891130170210250282310325364381420461494504
and345167000833271111
Genetic358467000834481120156179195228
Testing.21406800083336593117134173213227
Genes238968000834374112143169
(Basel).257668000831954911161471631822756680008312
2022;13(3).279068000833570105141154185216235270288300
https://doi.org/10.3390/31116800083396187127155169196218255294311324364386426453488520534570605639676702
genes13030471.214069000833873111146173203233267301335371403436445
18.21407000085366985
Kalra22467000083356984105138
DK,24057000083458195
Raina25217000083356883121154
A,269570000834155
Sohal277170000833271109142157
S.294970000833245
Neurogenic301570000834580118139176216251289304336
Orthostatic33727000083476893131170197220253274290322
Hypotension:37147000083447621407100083397799133171198212250289301
State24597100083325386108142
of261871000833857
the26937100083216094
Art28057100083416387
and291071000833270109
Therapeutic303771000833271106128161200235273296311343
Strategies.33987100083325375108129163203218253279293
Clin37097100083385267103
Med214072000835383119
Insights2275720008315527589125161182206
Cardiol.249772000833873941281431781942690720008312
2020;14:1179546820953415.272272000833468101135148178209221251279308341375411447482516550585619652688718748760
https://doi.35017200083385984123150162189210245284299312
org/10.1177/1179546820953415.21407300083375997123156188200231259288323343376403433466500535572607641675710744777812843873885
19.21407400085377185
Kim224674000833653112
JJ,23807400083254962
Vitale24647400083365377111127163
D,264874000834758
Otani272874000834872106146162
DV,29117400083468393
et302574000833558
al.31057400083324962
Multi-ancestry318974000835595111134150173206246279314342366388423
genome-wide363474000833975114154214075000835893117169185225260
association24217500083325986125158173206228244282321
meta-analysis276375000835894116149172205244276292324352367393
of317775000833858
Parkinson's32557500083366890121138176203242281292318
disease.35897500083395481116148175211223
Nat214076000834379100
Genet.2256760008342721091401612417760008312
2024;56(1):27-36.245076000833468101133145180215234265280292327360379411446459
https://doi.org/10.1038/s41588023-01584-8.29307600083375983123150162189210245284299312350372410437470501514545576610644669694730760791825860214077000833467102124161193223257293316352366
20.39404100085367186
Koeglsperger403941000833572107146161187225260281319353374
T,442641000833241
Rumpf448041000833572129168187
SL,46804100083326276
Schliesser476941000833264101116131165192218253274
P,505541000833539
et510741000833456
al.51754100083324760
Neuropathology52474100083457911713717421324626730534339404200083155292123
of407642000833756
incidental4145420008314528499137172209230263278
Lewy443642000833165115149
body459842000833877116147
&4758420008339
prodromal48104200083385996135156193251283298
Parkinson's51214200083356687117134171197235273284310
disease.5446420008337527811314439404300083266173
Mol403343000835389104
Neurodegener.4153430008342731091291642012312672973343643854534430008312
2023;18(1):32.456543000833569102136148178209228260274286321354366
https://doi.org/10.1186/49504300083385984123150162189210245284299312350372410436469501513544572603638663
s13024-023-00622-7.39404400083265686121154185208246278313335372408444478512533564570
21.39404500085367082
Kuang403545000833572104142181
Y,423045000833543
Mao428745000835487125
H,442645000834456
Huang449645000834482114152191
X,470145000833851
et476645000833456
al.48354500083324861
Alpha-Synuclein49094500083415695134166189220250289326358374409424462
seeding53844500083266197136151189228
amplification394046000833289127143158175192223256277292329367
assays43204600083315884116147173
for45064600083185576
diagnosing45954600083385284123160198224239276314
synucleinopathies:49224600083265896133165180214229266304343376397435450484510522
an545746000833169
innovative553846000831552394047000833775106139160175207240
tool41934700083215795111
in431647000831552
clinical4381470008330456097112143175190
implementation.458447000831471110125159216251288309342363378415453466
Transl50624700083314780116139153
Neurodegener.5225470008342721081281621982282632933293593795601470008312
2024;13(1):56.394048000833468101133145175205223255269281316351364
https://doi.org/10.1186/s40035-024-00449-2.43194800083385984123150162189209245283299312350371410436469500513544571602638663687723759795828861883921953985100810451082111811551188121212421255
22.39404900085367288
Lee404549000833166101
WJ,41634900083577991
Baek427149000833568103133
SH,44214900083337790
Im452849000831472
HJ,46174900083446981
et471549000833457
al.47894900083314760
REM486649000833569124
Sleep50074900083324882118157
Behavior518149000833571109141173188226248
Disorder5446490008345618712514739405000083387293
and404650000833270108
Its41675000083153764
Possible42445000083357198124139177193228
Prodromes44845000083355693132153190248283309
in480650000831452
General487150000834378116151172204220
Population:510350000833572111149164196217233270308320
Prevalence,5436500008335558912115439405100083155088120154166
Polysomnography41255100083357187119146184243281319359380413452490521
Findings,46655100083324785124139177216242255
and493951000833270109
Associated50675100083416996134167182214236269309
Factors.53955100083326294118155177204217
Neurology.3940520008342721071271621762112472754213520008312
2023;101(23):e2364-e2375.423752000833467100134145174205236250284318334346380413447481517539575609643674706718
https://doi.org/10.1212/49675200083375882120146158185204239277292304342363400426458489501531560591620646
WNL.0000000000207947.3940530008357103135149184220256292328365401437473509542576609642678710716
23.39405400085367286
Lyu40395400083315997
Z,414854000833750
Zheng421154000833774109146184
S,440854000833244
Zhang446554000833774106143182
X,465954000833851
et472254000833456
al.47905400083314659
Olfactory48615400083476381114146169206227260
impairment513454000831471109142157177235269307328
as547454000833258
an554454000833169
early39405500083346687103135
marker409355000835890111142176197
of430955000833757
Parkinson's43845500083356788119135173200238276288313
disease47135500083385379114146173208
in493955000831553
REM501155000833569124
sleep51545500083264176111150
behaviour532355000833974113145176192230268289
disorder:39405600083385278115136173208228241
a4194560008331
systematic42405600083255783106139196227249263295
review45475600083205385100134184
and474456000833168106
meta-analysis.486356000835690112144166197235266281312339353378391
J5265560008324
Neurol529956000834272107127161176
Neurosurg54855600083427210739405700083205579114134169
Psychiatry.412157000833458871171531682032242452764394570008312
2021;92(3):271-281.442257000833468101132141176209226260277289324357390408439473505514
https://doi.org/10.1136/49525700083375983123149162189209245283299312350371409435469500513543571601635661
jnnp-2020-325361.39405800083155391130153184218251285309342374409442477507516
24.39405900085367186
Maskova404559000835487114143181213246
J,430959000832437
Skoloudik436459000833362100116154192231246276
D,465959000834556
Stofanikova47345900083325390109143181196226263295328
P,508159000833539
et513959000833456
al.52145900083324760
Comparative529259000834077136175208229262284299394060000833266
study40226000083264987126158
of419660000833857
the42696000083226095
substantia438060000832663102129152185223245260292
nigra46886000083375391113146
echogenicity485060000833466104143182217255270302317340373
and523960000833270109
(123)I-Ioflupane5364600008319518111513214817018722539406100083173471111144182217
SPECT417361000833368100140176
in436661000831452
patients44356100083397293109143181203231
with46826100083516689127
synucleinopathies48266100083265897135167182217232270308348381403441456491518
with53606100083516689127
and550461000833270109
without39406200083506588125163201223
REM417662000833568123
sleep43116200083264176111149
behavior447362000833874111143174190227249
disorder.47346200083385379117138176210231241
Sleep49866200083304474104140
Med.5136620008353831185253620008312
2020;70:116123.52786200083346710013314617921122425328131239406300083346499111
https://doi.org/10.1016/j.sleep.2020.02.012.4067630008337598312214916218920924528329831134937140943546850051254357460663766367969271973476980584485689292695999310061041107410861121115311831196
25.39406400085377591
Norcliffe-Kaufmann405664000834686109142158174195215251276314349389409471505545585
L,466664000833247
Kaufmann473864000833671110131192226266306
H,506964000834559
Palma51536400083377087147181
JA,53596400083256782
et546664000833558
al.55496400083335064
Orthostatic39406500083476993132170197220253274290322
heart428065000833873105126150
rate44496500083215475109
changes457765000833169101139178213240
in483665000831452
patients49076500083387193108143181203230
with51566500083516689127
autonomic53016500083327092129168206264279311
failure3940660008318516681117138172
caused412466000833163100126160199
by433666000833869
neurodegenerative441766000833772109129166205239278313350384405438459474506539
synucleinopathies.49696600083265896133164179214228266303342375396434448482509522
Ann550366000833773109
Neurol.3940670008342721081281621774116670008312
2018;83(3):522-531.41416700083336798129140175209226259276288322355389409443475505514
https://doi.org/10.1002/ana.25170.46686700083375882121147159186206241278293306343365402428460491504534565600633659689726758771806841871900932945
26.39406800085367187
O'Hara404068000834760104137158190
DM,4243680008345100113
Kalia4369680008335688498130
SK,45126800083326781
Kalia4606680008335688398130
LV.47496800083316372
Methods483468000835489111149187226252
for50996800083185677
detecting51896800083387395128161185200238276
toxic54786800083225888104136
alpha-synuclein39406900083324785123155177204236274311343358392407445
species439769000832665100132147181208
as461769000833258
a4687690008332
biomarker47346900083385391149181201232265286
for50336900083185576
Parkinson's51226900083356687117133171197234272283309
disease.5446690008338527811314439407000083266173
Crit4026700008338587293
Rev41297000083346494
Clin42347000083385267103
Lab434770000832964100
Sci.445770000833160754530700008312
2020;57(5)291-307.455570000833468101134147182215231265283316350381400432466499505
https://doi.org/10.150737000083375883122148161187208243281296309347368406432465496509539
080/10408363.2019.1711359.394071000833470105129163194230266302336370404416452486518548559590620652680710743775786
27.39407200085367180
Poewe404172000833572108159193
W,425572000835767
Seppi434372000833267106146162
K,452572000833550
Tanner45957200083336199137172193
CM,480972000834095109
et493872000833456
al.50157200083324760
Parkinson50957200083366889119136174200239277
disease.53927200083395480115147174209221
Nat394073000834481103
Rev40617300083356798
Dis41777300083456286
Primers.428173000833455711291601822084490730008313
2017;3:17013.452473000833671104135146182194225256291324355369
https://doi.org/10.1038/49157300083386186127155169197218256295312326365388428455490523536568601636671698
nrdp.2017.1339407400083385997136148184218250280286317347
28.39407500085367288
Postuma40437500083357299122160218250
RB,43087500083357184
Berg44077500083357092130
D.455275000834556
Prodromal46237500083355693132154191249281297
Parkinson's49357500083356788118135173199237276287313
Disease:52637500083466187122154181216228
The550675000833272107
Decade394076000834479110142180213
Past,41657600083356591113126
the43027600083225992
Decade440676000834479110142180213
to463176000832157
Come.470076000833975131165177
Mov488976000835287115
Disord.501476000834358801141341685180760008312
2019;34(5):665675.52047600083336697126138172206225257275286320354387394077000833467100112
https://doi.org/10.1002/mds.27670.40677700083385983123150162189209245283299312350371409436469500513543575611644671727766792806842875907940973985