1038
NEUROLOGIE3418040010757101158205267310370429450493
PRO856804001074591154
PRAXI1031804001074591148201221
/12988040010731
Neurol.1374804001075593139165209227243
praxi.1633804001074672114152170186
2025;26(2):163-1681836804001074487128172185229272295338360375412451494521560599644
/25258040010731
www.neurologiepropraxi.cz460880400107651332012142633073553814284484965465656086586857327828098518919109269661005
1681288020012657111170
Z341200012659
POMEZÍ422200012660135225283345379
NEUROLOGIE823200012671129202266342398472544579637
Modifikovatelné34136001065292132150180198233272310346374406438480511
rizikové8683600106335184101137176213245
faktory112936001062866101135174210247
demence139136001063870125156198232264
se34062001093681
doporučuje440620010950100152203233283324373395441
tzv.89962001093070117132
středomořská10496200109356696141193243318369398435477522
dieta,158962001095172118148192212
která181962001094275119149193
při34076001095182103
dlouhodobé46976001095173123173224274326377429475
konzumaci97076001094291142182232308352393414
snižuje141076001093586107146196218264
riziko17007600109305190112155204
až192976001094484
o340900010949
1140890001094583
%506900010971
(Nucci59390001092583133173212233
et84290001094474
al.,9329000109436483102
2024).105090001094691135178202218
Středomořská128490001094472102146197247322371401437479523
dieta182390001095071116146190
obsahuje3401040010950102137182232282304350
potraviny7151040010952102132162206249271321362
bohaté11031040010951102153197226271
na1400104001095093
antioxidanty,1519104001094394123145195236258309353403433478493
zdravé340118001093990119163206250
tuky610118001093080122168
a7981180010943
esenciální861118001094581127177218239283304354375
vitaminy125611800109446596140215236286328
a16041180010943
minerály,1667118001097596146192222266288331346
které340132001094173116145189
zvyšují543132001093883127162210231251
odolnost809132001094898147168216265299329
mozku11531320010973122158200248
různými1416132001092978115164204278298
cestami1729132001094083117147190263284
–3401460010945
skrze408146001093678109150195
redukci626146001092975126176218258279
zánětlivých928146001093984134180210231252296342382432
procesů1383146001095181131172217252302
a17081460010943
snižují1774146001093686107146195217238
oxidativní340160001095193116169214245267312365387
stres753160001093769100146184
a9631600010945
hladiny1034160001095274119172194246289
LDL13491600010944106150
cholesterolu1526160001094193144167215252284330361412435486
(Mena340174001092697143193237
et596174001094575
al.,69017400109446584104
2009).813174001094692140187211228
Shrnutí2140590014762131174243312354385
Protektivní228076001094979130161207251285307352405427
působení2733760010953104141193246294346368
optimalizace3128760010950103135157234279301323363410452498
modifikovatelných3653760010976128214090001095173101125168218261306336382404455497538589
rizikových27559000109305292114157206250297337388
faktorů316990001092772115149199229280
zahrnuje347590001093985137167218269291337
čtyři2140104001094174120151174
klíčové234010400109436788130180223269
mechanismy:26351040010977124166217262313335372448491511
snížení3173104001093687109149195247269
vaskulárního34681040010944891261692212432883182140118001095071123173
poškození,23371180010951102137180228266312362383402
snížení2763118001093686107146192242263
neuropatologických3050118001095096146175225277321351400422472523544585627673713763
změn,21401320010939114160210229
snížení2389132001093686107146191242263
míry2672132001097596126171
zánětu2863132001093884134179210260
a31421320010944
stresu320513200109356696141177226
a34511320010943
posílení35131320010952102138159182228278299
tvorby2140146001093077127158210253
kognitivní2419146001094393145196218249271315367389
rezervy2834146001093076116163193241287
(Livingston314814600109266890135157208260296328378429
et3604146001094576
al.,370714600109446685105
2024).2140160001094589132175198214
Včasná2369160001094986129164212254
identifikace2638160001092171115164193213238261302346385428
rizikových308116000109295087108149196238282321369
faktorů3465160001092669110142189218267
je3747160001092166
klíčová214017400109426485125173215258
pro2414174001095180129
potenciální25591740010950100130174224264285328349398419
intervenci2993174001092171100144173219263313353374
a33821740010943
specifická3444174001093586131172193219243283324368
doporučení3940620010951101153203233283324369419440
v4398620010943
klinické44606200109426586136157198240285
praxi476262001095181125168190
(Tab.496962001092673111162181
1).51676200109466683
Prevence526762001094877122165210260301346
demence394076001095196172218268309354
by431576001095294
měla4431760010975120142186
být463976001095193126
prioritou478776001095181103152183204234283333
nejen514276001095096118163214
v5378760010943
individuální544076001092171122144394090001094365116166210231281302
péči426090001095298139160
o4438900010950
zdraví,450790001093889119163205227246
ale477190001094465111
i4900900010921
v4940900010943
rámci500390001092973148189210
veřejného523190001094488118163185235281331381
zdravotnictví3940104001093990120165207256287337359400432478500
–44661040010945
podpora45371040010951102155207258288332
vzdělání,4895104001094385136182204248299320339
prevence5260104001095182127171216267308353
kardiovaskulárních3940118001094286115165186235277320355397446467510539589610650699
a46541180010943
metabolických47151180010975120150193244294315336376417462501551
onemocnění,52811180010949991442182683083940132001095095145166185
dostupnost41411320010950100135166215266316366401432
naslouchátek,4589132001094992128149198248289338381411455498519
léčba5124132001092166107158202
poruch53411320010951102131181222271
zraku3940146001093968112155205
či4163146001094061
snaha4242146001093585129179222
o44821460010949
zlepšení4550146001093961106158194239290311
kvality4879146001094288132154175205250
ovzduší5147146001094992133184233269290
jsou5455146001092257107158
kroky,3940160001094273123166212227
které4192160001094275120150195
mohou44121600010976126176226277
výrazně4714160001094389120164204254300
snížit5039160001093686107146168198
zátěž5262160001093984114159198
demence548516000109519739401740010975121171212257
ve4216174001094388
stárnoucí4323174001093566111140191241291332353
populaci.46951740010951102154204225269310331350
LIETRATURA341197001234978133190250319369439499568
1.34021400853648
Cohen40121400834077115150188
AJ,6022140083406779
Brauer6942140083355689127161183
M,88921400835568
Burnett9702140083357394132167189213
R,119621400833649
et125821400833456
al.13272140083324760
Estimates1400214008332608398155187209243269
and168221400833270109
25-year18032140083346991123157189210
trends3402240083224377115154181
of53422400833857
the6052240083216095
global7142240083385391131164179
burden9072240083387798136171209
of113022400833756
disease12002240083385380115146173208
attributable1422224008332537899115154192215247287303337
to177322400832259
ambient1846224008331891281443402340083347294
air4472340083324768
pollution:5292340083397894109146169184222261273
An81623400834179
analysis90923400833169102117149176191217
of114023400833756
data12102340083387092125
from13492340083184078136
the14992340083216094
Global16072340083446098138171186
Burden18072340083357394132167205
of34024400833755
Diseases4082440083445985119150176210237
Study6572440083325290128159
2015.8282440083346798128139
The9802440083306797
Lancet.10872440083286399128156176189
2017;389(10082):1907-1918.12852440083346798127136170204238256287318353388421438450479508543575593623653684714727
https://doi.org/10.1016/S0140–6736(17)30505–6.34025400833859831231501621892092452832993123503714094364695005135435756076386636967317637948308689059389721006102510571086110611391173120812421276131213491363
2.34026400853754
Daviet41726400834780113130167190
R,63026400833752
Aydogan70526400834273113153194228268
G,99626400834559
Jagannathan10792640083245899133172212246269309343382
K,148426400833652
et155926400833559
al.16412640083324963
Associations1727264008342719913917318922324626234027400833879106
between46927400834077100156192229268
alcohol7602740083334983121162202219
consumption100127400833371111139178238279302318358398
and142227400833372113
gray15582740083396296128
and170927400833373113
white184527400835292109132168
matter34028400835790111136170191
volumes5462840083316985122180215242
in80328400831553
the8712840083226095
UK98128400834479
Biobank.10752840083365189128161199230244
Nature13342840083437999135156185
Communications.153128400833872129185220257272301336357371407444468481
2022;13(1):1175.3402940083346799134146175204222253267279308335364396407
https://doi.org/10.1038/s41467–022–28735–5.7602940083375882120147159185205240278293305343364401427459490502532563596629654678713743774809841873910942976101010411074110611401172120812411252
3.34030400853652
Fang41330400833363101141
M,57530400835569
Hu66530400834583
J,76930400832537
Weiss82730400835892107134161
J,100930400832537
et106730400833457
al.11453040083324861
Lifetime12273040083324868103125141200235
risk1483304008321376494
and159830400833371111
projected17303040083396199115150184208243283
burden3403140083397798137172210
of57131400833757
dementia.64831400833873132167205227242274288
Nature95731400834379100136157186
Medicine.116031400835384120135165179216246259
2025;1-5.143631400833469102137148178197231243
https://doi.16993140083386084124151163190211247285301314
org/10.1038/s41591–024–03340–9.3403240083375997123156188200231262296330355380416446476508540573610643675712750783816851887925960971
4.34033400853651
Farina408334008332628399136169
FR,5933340083336882
Bridgeman6913340083355772111150185243275313
K,102133400833549
Gregory10873340083436599139177198232
S,133633400833245
et139833400833456
al.14703340083324760
Next154733400834480111135
generation169933400833873111146167200222237275314
brain3403440083396093108146
health:50234400833772104120142180192
Transforming7103440083325083121147167205226285300338377
global11023440083385492131164180
research12973440083215582117149170201239
and155234400833169108
public167634400833977116132147179
health18703440083387310512034035400832260
to41435400832259
promote4883540083386097155194216249
prevention7523540083396094127161199221236274312
of107935400833756
dementia115035400833873131166204226241273
and143835400833169109
reduce15613540083215594132164198
its17743540083143764
risk1853354008321366292
in196035400831552
young34036400833168106144183
adult53636400833271109124146
populations.69536400833978117155171203225240278316342356
The10643640083316898
Lancet117336400832964101130159180
Healthy136436400834273108123144180208
Longevity.158336400832963100136166196211232263274
2024;186836400833468101133145
0(0).3403740083345487106117
https://doi.org/10.1016/j.lanhl.2024.100665.47237400833859841231501621892092452832993123503714104364695005135445756076386636796927087417798178328458819159489809921023105510911127116211961208
5.34038400853650
Fortea4053840083327091116150182
J,60138400832436
Pegueroles65238400833568108145180202239255290316
J,98338400832436
Alcolea10343840083415688125141176208
D,125638400834556
et132738400833456
al.13973840083324861
APOE4147238400834177124158191
homozygozity167838400833775134172200234273311340394008328436598
represents4503940083215493114147174208246267294
a756394008331
distinct8023940083385378101116153184208
genetic102239400833872110144166181212
form12463940083195677134
of139339400833655
Alzheimer’s14613940083405584121156171227262282296321
disease.17973940083375278112143169204215
Nature3404040083427797132151180
Medicine.52940400835282117131160174209238251
2024;30(5):1284-1291.7904040083346698129140174208226259276288316345378413435465494527558567
https://doi.org/10.1038/13684040083375881119145157183203237274289301338359396421453483495525555587621645
s41591–024–02931-w.3404140083266292122155187220257290322359396429463496527545597608
6.34042400853753
Graham41442400834467101140173232
NS,6674240083467992
Sharp78042400833372105127168
DJ.9694240083466982
Understanding107242400834583123159181209233267306346361400440
neurodegeneration1533424008339741131351732142492903263654014234563404340083223776115
after4764340083325177111132
traumatic6294340083224477115174207229244277
brain9274340083396194110148
injury:10964340083155368106128162176
From12934340083335390149
mechanisms146343400835894127165198237252279337364
to184843400832159
clinical192843400833147623404440083385386119135
trials496444008322446092108134
in65144400831554
dementia.72544400833974133169208229245278291
Journal10374440083246097118155192207
of126144400833554
Neurology,133244400834475111132167183219256286297
Neurosurgery164644400834374111132167191227248283314334366
&340454008338
Psychiatry.3954540083345989118155170206227248280291
2019;90(11):1221-1233.70745400833469101132145181217237269297312324355385420452471502533568601614
https://doi.org/10.1136/13424540083386085125152164192212249287303316355377416442476508520552580610645671
jnnp-2017–317557.3404640083155391130153184218250280312344375405437470503509
7.34047400853645
Grande4024740083446598136175210
G,62947400834457
Ljungman7034740083324785123162220252290
P,101047400833540
Eneroth106747400833270105126164186224
K,130847400833549
et137447400833457
al.14484740083314760
Long-term152547400833168107146168191224246304
Exposure1846474008333651051433404840083266384119
to47848400832259
Air5564840083415778
Pollution6534840083357288103141163178216255
and92848400833169108
the10564840083226095
Risk11704840083365177107
of129748400833756
Dementia:137348400834581139174212233249281293
The168548400833372107
Role18124840083357389124
of195648400833756
Cardiovascular3404940083397292130145182213246272303341355387408
Disease7604940083456086120151177212
(1839).9844940083185080113146164174
Neurology.117149400834272108128162177212248276287
2020;94(15_supplement):1839.14684940083346710013314618021623526629533035839543347248852234050400835996137160181195226260296331344
https://doi.org/10.1212/WNL.94.15_supplement.1839.71650400833962881301591732022242623033203353753994394685035375515846166496817107748228578729089469609931025106310931133117512171234127134051400835792131152165196227261294305
8.34052400853652
Griffiths409524008344658199117135158196222
TD,6485240083327990
Lad75552400833165104
M,87552400835568
Kumar96052400833572130162183
S,116052400833345
et122252400833456
al.12955240083324760
How137252400834482133
Can152252400834073111
Hearing165052400834479111132147185224
Loss18915240083316996122
Cause34053400834072109136170
Dementia?52353400834580137172210231246278302
Neuron.83653400834373108129163200213
2020;108(3):401-412.106153400833468100134147177208243262295312324358393425443480510539551
https://doi.org/10.1016/j.neuron.2020.08.003.162553400833759831221481611872072432812963093463683405440083386497129141172204235267292308321360395432453491529542578612645679692727763776811847880893
9.34055400853650
Huuha41155400834583121159192
AM,62455400834198112
Norevik75655400834584106141174190220
CS,9975540083407588
Moreira110655400835594116150166187221
JBN,134755400832561107121
et148955400833456
al.15665540083324861
Can164855400834174112
exercise178155400833567101123154170196232
training340564008322437692130145183222
teach5825640083225688120158
us76156400833763
how84556400833876127
to99356400832158
treat10725640083224377109131
Alzheimer’s12245640083415685124159174232267289303328
disease?15675640083395480115147174209234
Ageing182256400833873104119155191
Research3405740083346591121157178207244
Reviews.6015740083356697112142192218232
2022;75:101559.85457400833569103138151184218229259291324355388420432
https://doi.org/10.1016/j.13075740083386085125152165192213250288304318356378417444478510523554586618650676692706
arr.2022.101559.340584008332537585121155188223235266297329359392424435
10.3405940085367085
Iso-Markku4455940083154179103159191212243274313
P,77859400833540
Kujala8385940083357288120135167
UM,102659400834398112
Knittle11585940083357489112136152187
K,136559400833550
et143559400833456
al.15125940083314760
Physical159259400833573103130145177210226
activity1838594008332648810313615234060400832256
as41760400833260
a498604008332
protective5466040083396199121156189214229263297
factor8646040083195386110148170
for10556040083195779
dementia115560400833974133169208230245278
and145460400833271111
Alzheimer’s15866040083415787126162177236272293308334
disease:1936604008338543406140083276395123158171
Systematic5336140083336391115150209242265280313
review,8676140083215690106142194205
meta-analysis109361400835894117151174207246279295328356371398
and151261400833372112
quality164561400833977110126142165200
assessment1866614008332598712334062400832653110145183205
of56162400833756
cohort63362400833168107145166191
and84062400833270109
case-control9646240083316491126149183220258280301338354
studies.13346240083264987126141176203216
British1566624008334546990104128163
Journal17426240083246096117153189204
of195962400833553
Sports34063400833165102122145169
Medicine.52063400835383119134163178214244257
2022;56(12):701-709.79063400833468101135148182217235267297315326360392424443474507542553
https://doi.org/10.1136/13556340083385983123149162188209244282298310348370408434467498511541569598633658
bjsports-2021–104981.3406440083395480119158180204232253284318351382415446478514547582614623
11.3406540085366678
Kivimäki4326540083355184100157190220236
M,68265400835468
Walker76365400835889104134168190
K,96665400833550
Pentti102965400833569107129153168
J,121165400832436
et126165400833356
al.13306540083324860
Cognitive140465400834077116154170192207240274
stimulation16926540083264964122160175207229244282321
in34066400831451
the4036640083215993
workplace,50866400834986107137176191222254286298
plasma8186640083385384110166198
proteins,10286640083385995116149163200226238
and127866400833168106
risk1396664008320356190
of149866400833655
dementia:156566400833771128162199220234265277
Three18546640083327091124158
analyses214021400833270102117149176211238
of239421400833757
population246721400833877117155170202224239277316
cohort279921400833168107145166191
studies.30062140083264987126142176203217
BMJ.323921400833487112125
2021;374:n1804.337921400833468101133141176208238250288318349384421433
https://doi.org/10.1136/bmj.n1804.21402240083385983123150162189209245283299312350371409436469500513543571601636661701759774787826856887922958971
12.21402340085366884
Knopman223723400833574112152210243281
DS,25312340083457891
Amieva263523400834199114149181214
H,286223400834457
Petersen29322340083356991125146173208246
RC,31912340083367789
et329423400833456
al.33632340083324760
Alzheimer34362340083415786124159174232267288
disease.37382340083385321402440083266193120155167
Nature232824400834379100136156186
Reviews25312440083346495109140189214
Disease27622440083445983112148172202
Primers.29812440083345368124155176201214
2021;7(1):1-21.321224400833468101133141174191223237249279298329360370
https://36022440083386084124150163190210
doi.org/10.1038/s41572–021–00269-y.21402540083387692105143164202229262293306337368401435461485521551582615649683721754785818855891924958991101510471057
13.21402640085366883
Livingston2242264008331477995133172198221258297
G,255826400834457
Huntley263426400834482120142157192224
J,287726400832436
Liu29322640083324785
KY,30362640083357381
et313626400833457
al.32122640083324760
Dementia329126400834581139174212233249281
prevention,3591264008339609412716119921402740083223775113126
intervention,22822740083155374108129164198236258273311350362
and266127400833270109
care:27862740083316485119132
2024293427400833468101133
report30832740083215594133155179
of327927400833756
the33512740083226095
Lancet346327400833164102135168191
standing3670274008326498212021402840083385391130
Commission.228628400834077135193208234261276314352366
The26682840083316898
Lancet.278028400832964100130159180193
2024;404(10452):572-628.298628400833468101133145180215252271303334371403437454466502535569590627660694707
https://doi.org/10.1016/S0140–6736(24)01296–0.37102840083375983214029400833965781051251611992142272662873253513844164294594915225545796126476787097457838218538889229419751007102410591091112111551191122812661278
14.21403040085366984
Lloyd-Jones22413040083314785116155177198237275310337
D,259430400834657
Adams266730400834179111169196
RJ,28793040083356274
Brown29703040083355694145183
TM,317030400833287101
et328730400833457
al.33603040083324760
Executive34363040083336699132170192208240275
summary:3727304008326632140314008359118152174209223
Heart238431400834582115137162
disease25683140083395481118151178214
and280431400833271112
stroke29373140083275173112143179
statistics--201031373140083275185107123150174190223252274298330366398431
update:358931400833879120153176210224
a2140324008332
report21883240083205594134155180
from23893240083184178137
the25473240083226095
American2663324008341100135157172205238276
Heart296032400834480112133158
Association.31393240083416996135168183215237253291330343
Circulation.350332400833853731021381531892102252612983800324008312
2010;121(7):948-954.214033400833571104136150181213245261297318330367404442465502537574587
https://doi.org/10.1161/CIRCULATIONAHA.109.192666.274933400833861861271551681962182552943113253643874264544885215345665956286596827237387768188638979419729891039214034400834586130172186217249284295325356389422458494507
15.21403540085366984
Ma224535400835588
H,235435400834558
Li243335400833248
X,250235400833852
Zhou257535400833877116155
T,275135400833342
et281435400833457
al.28923540083324861
Alcohol29743540083425890128167206222
Consumption321735400834179118145182241281304319358397
Levels363535400833267100135151177
as214036400833258
Compared221836400834077135174207229263302
With25403640083577496134
Drinking26943640083456783121151167205244
Habits295836400834476115131153181
in315936400831552
Predicting32313640083355690130145177201216254293
All-Cause3544364008341567194137169207233268
Mortality214037400835493114139172187202225258
and241837400833270109
Cause-Specific254737400834073110137172195226265300333348366383415
Mortality298237400835493114139172187202225258
in326037400831553
Current33333740083397697119153191213
Drinkers.35653740083466783121151185206234247
Mayo214038400835389118153
Clinic23073840083385368104119148
Proceedings.24693840083345388119148178214229265301324338
2021;96(7):1758-1769.282238400833468101133141176212231265285297327356389423446476506538572583
https://doi.org/10.1016/j.mayocp.2021.02.011.3422384008337598312315016218920924528329931235037121403940083386497129141172204235266292308321379412443480513552565601635668699708743776789824856883893
16.21404040085377188
Matuskova224940400835689112151178209247280314
V,258540400833646
Ismail265240400831542101135150166
Z,284040400833852
Nikolai29134040083466293131148181197
T,313140400833443
et319540400833558
al.32754040083324862
Mild33584040083567287128
Behavioral350740400833672112145178194233255289306
Impairment214041400831573113146161183242277316338
Is249841400831542
Associated25604140083427097135168184216238272312
With28934140083587497135
Atrophy30494140083416384122162201232
of330241400833757
Entorhinal33804140083327192130152190206244277292
Cortex3693414008340789921404240083225789
and225042400833372112
Hippocampus238342400834561101141181215248308348387414
in281842400831554
a2893424008333
Memory294242400835591150190212247
Clinic32104240083415772111127159
Cohort.339142400834078118157179205219
Frontiers3631424008331508612414516021404340083305177
in223443400831552
Aging23034340083387590127163
Neuroscience.248443400834374111132168192222237268305336365379
2021;13.288443400833570103135144175205218
https://doi.org/10.3389/31234340083396186126153166194215251290306320358381420446480512525562595631666690
fnagi.2021.643271.21404440083185790129144157193227260291301336372405438470503512
17.21404540085366876
Mena223245400835490128160
MP,24074540083559195
Sacanella,25184540083326597130168203219234266279
E,281245400833346
Vazquez-Agell28734540083366797135173207237259300338373389404
M,329245400835568
et337645400833356
al.34474540083324760
Inhibition35384540083155391106145161183198236275
of214046400833858
circulating22194640083314769100139155187210225264304
immune254446400831574132171210245
cell2810464008332668398
activation:29294640083326590106139173195211249289301
A3251464008342
molecular331446400835897113149182221237270291
antiinflammatory3626464008332719310912516321404740083173466124182214236273294328
effect24834740083345473107140164
of266247400833857
the27344740083226095
Mediterranean284447400835489129144167200222243276314349381419
diet.32784740083385488111124
The341747400833372107
American353947400834199134155171203236274
Journal214048400832462101122160193208
of236548400833757
Clinical24394840083405570108123155188203
Nutrition.265948400834582105126142165180218256269
2009;89(1):248-256.294648400833468104139152187221241272287299334366402424455490524538
https://doi.35014840083375983123149162189209245283298311
org/10.3945/ajcn.2008.26094.21404940083375997123156188200236269305338361392407439477491527561597632646682715751786822834
18.21405040085377188
Mohamed224950400835695135168227264304
AZ,25755040083418296
Nestor269250400834682110134172194
PJ,29085040083355568
Cumming299750400834179138197213252292
P,331150400833641
et337350400833558
al.,3452504008332486275
&3549504008340
Alzheimer’s36105040083425888127163179214051400835893115129155
Disease23105140083466288124156183218
Neuroimaging254951400834580119140178193252284324339378417
Initiative.2987514008315536891107139161177210244257
Traumatic32645140083335184122181213235251283
brain35685140083396194110148
injury37375140083145321405240083155476112
fast-forwards22735240083195482106127147186209264298320360387
Alzheimer’s26825240083425889129165181241277299314341
pathology:30395240083407497137176193233274307321
Evidence33825240083346783124160199233268
from36715240083194281141
amyloid214053400833291122138177192232
positron239353400833978105120143165202241
emission265553400833493108135162177215254
tomorgraphy293053400832260118157179218239273312351383
imaging.333353400831573106146161200239252
Journal36065340083246097118155191206
of214054400833655
Neurology.221354400834375112133169185221259289301
2022;269(2):873884.253254400833570104140153189224259279314332345381415450486522560573
https://doi.org/10.1007/31265440083396186127155168196217254293309323362385424451485518531563595632666687
s00415–021–10669–5.21405540083266197133164194230267300332364395427462498532569603615
19.21405640085366982
Nichols22405640083456092130168184210
E,246756400833346
Merrick253056400835590111133149181211
R,275856400833549
Hay282556400834476107
SI,29495640083334760
et302656400833457
al.31005640083324760
The317756400833372107
prevalence,33025640083386094126159175209247280313325
correlation,364556400833168891111452140574008315487187126165179
and234057400833272112
co-occurrence24735740083327094135168200239261284319358391426
of292057400833858
neuropathology299957400833975114135174214248271310350366405446479
in349957400831554
old35755740083385494
age:369157400833272108121
Harmonisation214058400834578100160199238254281315337353392431
of259358400833857
12267258400833465
measures275858400835995127155193215250277
across30565840083336688126153181
six32585840083264274
community-based335358400833269129188227266281304339362403437214059400832661101
autopsy22615940083326992129168195227
studies25095940083264987126141176202
of273259400833756
dementia.280859400833873131166204226241273286
The311459400833372107
Lancet.324159400833265103135169191205
Healthy346659400834273108123144180209
Longevity.36915940083296310021406040083366798113134166178
2023;4(3):e115-e125.233560400833570103139151186206240258270306336364395418455485516552564
https://doi.org/10.1016/S2666–29206040083386085126153166193214251290306319358380419446480512525556589621653679712747781817854892
7568(23)00019–3.214061400833467101137156190224242277313349381411448481493
20.21406240085367390
Schaffert225262400833266106139160183219241267
J,254162400832438
LoBue260062400833170108147184
C,280562400834054
White288162400835798114138173
CL,30766240083397287
et318562400833458
al.32646240083324963
Traumatic33496240083325185124183217240257290
brain36616240083396296113152
injury21406340083155470109132167
history23266340083375481106144167203
is254763400831542
associated26086340083315987127161177211234269310
with29366340083516892131
an308663400833271
earlier31756340083346890107124160183
age337663400833272108
of350363400833758
dementia35796340083387513417021021406440083223872
onset222964400833777105141165
in241264400831454
autopsy-confirmed24836440083327195133174202236260295333373393410433493529570
Alzheimer’s30716440083415888128164181240276299315341
disease.34306440083385582119152180216230
Neuropsychology.36786440083437511221406540083205694119150181219256272309347378390
2018;32(4):410-416.255065400833470103135149185219238272291304340372405430468500532547
https://doi.org/10.1037/31206540083386186127155169197219256296313327367390429457491524538570603638671693
neu0000423.214066400833874113150188225263300334370384
21.39402140085367082
Shannon403921400833270103141179217255
OM,4311214008347102116
Ranson444321400833669107133171210
JM,46692140083257993
Gregory47792140083436599139177198232
S,502821400833345
et509021400833456
al.51632140083324760
Mediterranean524021400835590129144167201222244277315350394022400833270
diet40222240083385388110
adherence414522400833271109143164198236268302
is446022400831440
associated45132240083325885123155170202224257297
with48232240083506688126
lower496222400831553103138159
dementia513422400833872130165203224240271
risk,5418224008321366292107
independent553822400831452394023400833873112148186225260298319
of427523400833756
genetic434723400833873111146168183215
predisposition:45782340083386094134149175214253279294317332370408420
Findings50142340083324785124139177216242
from52722340083184077136
the54232340083226095
UK553323400834480
Biobank39402440083355087125158195224
prospective41762440083385996122160194226250265296330
cohort451824400833167104142163187
study.47172440083264885123154164
BMC489324400833385123
Medicin.502624400835282117131160174210223
2023;21(1):81.52592440083346799133144178209223254268279313344353
https://doi.org/10.1186/s12916–023–02772–3.39402540083385983123150162189209245283299312350371409436469500513543571602638663687717747781813844882919952987102310601093112611611195122912621274
22.39402640085367288
Sims404226400833247105131
JR,41872640083246074
Zimmer427526400833753110168203224
JA,45132640083246478
Evans46052640083326497135162
CD,47802640083408596
et489026400833456
al.,4960264008332476073
&5046264008339
TRAILBLAZER-ALZ509926400833269112128159195228271311343379401442474514
23940274008334
Investigators.39952740083155485120147171186226258280318340367381
Donanemab439727400834685124156195230289321361
in477927400831553
Early48532740083336688104136
Symptomatic501027400833262122161184221280313335350383
Alzheimer54142740083415786125160176394028400835995117
Disease:40782840083466289125158186222235
The433428400833374110
TRAILBLAZER-ALZ446528400833371115131164201234279320353390413455488529
25015284008335
Randomized507128400833770109150189249264294330370
Clinical5463284008340567211112639402940083316480
Trial.4040294008333506597113126
JAMA.418329400832461114153168
2023;330(6):512-527.437129400833468101136147182215250270303321333368399429450484517550556
https://doi.org/10.1001/49472940083386084123150163189210246284299312350372410436470501514544576612644666
jama.2023.13239.394030400831547105137151187221253288301332361394429462473
23.39403140085367184
Sommerlad403431400833269126182216235250280318
A,436231400834153
Kivimäki4425314008335508195152182211226
M,466131400835466
Larson47373140083326483109146183
EB,49303140083326677
et501731400833455
al.50823140083324657
Social514931400833369100114144158
participation53173140083397090113127157171209240260274394032400833773
and402332400833268105
risk4138324008320345886
of423432400833754
developing429832400833871101134148184221235271308
dementia.461632400833871126160196216229259271
Nature48973240083427695129148176
Aging.50803240083377184119153164
2023;3(5):532545.5251324008334669713014017318922123724828131234339403340083346899110
https://doi.org/10.1038/s43587–023–00387–0.4062334008338588111914415518120023427128529733335339041544747748851754757961263665969472575678982185288791995298710231058108911221154118512211232
24.39403440085367186
van404634400833265103
Dyck416834400834578110140
CH,43273440083408597
Swanson444434400833282115153179218256
CJ,47203440083406678
Aisen48183440083415682117155
P,499334400833539
et505234400833456
al.51283440083324760
Lecanemab52073440083326699131169204262295334
in556034400831553
Early39403540083326586102133
Alzheimer’s40863540083415685123158172230265286300324
Disease.44263540083456086120152178213225
The46643540083316898
New477235400834373122
England490435400833166102117152188224
Journal51383540083245995116152188202
of535135400833453
Medicine.54143540083538311913316317739403640083366578
2023;388(1):9-21.40283640083346799133144178212247265296310321356379409440449
https://doi.org/10.1056/NEJMoa2212948.4489364008337588112014615818420423927629130434136240042545748850053056159462865269773075681084787991394797810071040107511111124
25.39403740085367287
Villemagne4046374008336526782117175207247285320
VL,43843740083366983
Burnham44853740083367495133171204262
S,476537400833346
Bourgeat482937400833674112133172207238260
P,510837400833540
et516637400833457
al.52423740083314760
&5320374008340
Australian537837400834178105128149182198213394038400833270
Imaging402438400831573105144159197236
Biomarkers42753840083355088146179200230265286313
and460238400833270109
Lifestyle47263840083314666100127150184200235
(AIBL)49753840083196075111143162
Research51513840083367198133164186217255
Group.542038400834465103141180192
Amyloid3940394008341100132148187203242
β4203394008339
deposition,426239400833975114154181196219235274313326
neurodegeneration,460939400833873112133171211247287323361397419452474490529568581
and521139400833271110
cognitive534239400833269110148164187202236270
decline394040400833874107122137175211
in417140400831553
sporadic424540400832666105127160199215247
Alzheimer’s45134040083415686125160175233269290305330
disease:48594040083385380115147174209222
A5102404008341
prospective51594040083396098125164200233257273306340
cohort55204040083326939404140083387697122
study.40784140083264987126158168
The42594140083316898
Lancet.437041400832964101131160181193
Neurology.457641400834373109130165180215252281292
2013;12(4):357-367.488141400833468100130141171201219252269281316349383401433468501507
https://54044140083375983122149162188209
doi.org/10.1016/S1474–4422(13)70044–9.3940424008338769210514316420222926229330633736840043145648952055158361365068772475779280984187088891995298810251061109911331144
26.39404340085367086
Voronina40384340083357192128166181218250
TA.43004340083326983
Cognitive439543400834076115152167189204236269
Impairment467743400831471110142157177235269307328
and501743400833169107
Nootropic513643400834582120142163199238253285
Drugs:543343400834566103142167180
Mechanism394044400835591124162195233249275334
of429444400833858
Action43724440083427498114152191
and458444400833271110
Spectrum471544400833372108141166188226285
of502144400833757
Effects.50994440083335271106139164192206
Neurochemical532644400834374111131167197234265394045400835773104140156
Journal.41144540083246199121159196212225
2023;17(2):180-188.435745400833571105141154185216233269287300331364401426458490527541
https://doi.org/10.1134/49204540083396287128156169198219256296312326366389428456490523537569598629666692
S1819712423020198.39404640083326394126156189222252283316351385418452484514549563
27.39404740085367281
Yang404347400833666105145
L,420947400833246
Deng427647400834682121161
YT,44584740083357382
Leng456147400833267106146
Y,472847400833644
Depression,479347400834683123145180207234250288328341
Depression515547400834682122144179207234249288327
Treatments,55034740083335186394048400833356117155195219249263
and423548400833373115
Risk43824840083365381114
of452748400833960
Incident46194840083155590107148185226249
Dementia:490048400834784145182223246263298311
A5243484008343
Prospective53044840083365998127168206241267284394049400833369
Cohort403549400834180121161184210
Study42724940083335695136170
of446949400833859
354,313455449400833570107120158190222
Participants.48024940083377093119136169186227262302325354369
Biological51974940083355188104142180196227264280
Psychiatry.5498494008335609139405040083306885122145167200212
2023;93(9):802-809.417950400833572107144157194229249284304317354392427449487525562575
https://doi.org/10.1016/j.biopsych.2022.08.026.47865040083386288130159173202224262302319334375398438467502536550583616650684711729743786803394051400833777104136168206219255289322356369404440453488521555568
28.39405240085377592
Yeo405452400833669109
BSY,418552400833670107116
Song432352400833474114154
HJJMD,44995240083467297154202214
Toh473452400833469110
EMS,486552400833491126139
et502652400833559
al.51065240083335063
Association51915240083427199139173189223246262301342
of555452400833959
Hearing394053400834479111132148186225
Aids41855340083415796122
and432753400833270109
Cochlear445753400834077110148163198230251
Implants472853400831573112128161199220248
With49965340083587496135
Cognitive515153400834077117155170192208240275
Decline544653400834581114129144394054400833873
and403354400833270109
Dementia:416254400834681139174212234249281294
A4476544008341
Systematic45335440083326289112146204236258273305
Review485954400833570103118153204
and508454400833270109
Meta-analysis.521354400835590112145168200238270286318345360386399
JAMA394055400832461114152
Neurology.410555400834373109130164179215251281292
2023;80(2):134-141.441255400833468101136147183218237271289301331361396419450481511521
https://doi.org/10.1001/49485540083375983123149162189209245283298312350371409435469500513543575611643665
jamaneurol.2022.4427.394056400831547105137175210248269306322335371405438473485520557589622628
29.39405740085367286
Yu404657400833570
RC,41375740083357689
Proctor42465740083355693126150187209
D,447557400834656
Soni455257400833271109124
J,469757400832436
et475357400833457
al.48305740083324760
Adult-onset491057400834180117133155175215253279314337
hearing526757400833873105126141179218
loss55065740083155379106
and394058400833270110
incident40715840083145385100140175213235
cognitive432758400833169109147162185201234268
impairment461658400831573112146161183242277315337
and497458400833270110
dementia510558400833873132167206227243275
–5401584008335
a5457584008332
systematic55055840083265986394059400832255113146167183215
review41725940083215587103137189
and437859400833270109
meta-analysis450459400835792115147170202240272288320347362388
of490959400833756
cohort498359400833168106145166191
studies.51915940083264987126142176203217
Ageing542259400833873104119155191
Research39406040083346590120156177206242
Reviews.41996040083356596111141191216230
2024;98:102346.4446604008332448060400833468100112148183196226257291326362398412
https://doi.org/10.1016/j.49126040083386085124151164191212248287302315354376414441474506519550582614645671687700
arr.2024.102346.3940614008332537585121155188220232263295328362398434447
30.39406240085377591
Zhang405762400833979113153194
B,427662400833751
Weuve435262400836094134168205
J,458262400832538
Langa464662400833368108149183
KM,485462400833696110
et499062400833559
al.50756240083324963
Comparison516462400834180140182216239256283324364
of555462400833859
Particulate39406340083366991116132165204220253275310
Air42716340083425880
Pollution43726340083367491106145168184223263
From46566340083335392152
Different48296340083466283102137159194234256
Emission510663400833493108135163178217257
Sources538463400833373112134166200228
and394064400833271111
Incident40736440083155487102142178217239
Dementia433364400834683142178217239255288
in464264400831554
the47176440083226197
US.48356440083457891
JAMA494464400832462117156
Internal51176440083155373103124162198214
Medicine.534864400835485122137168183220251265
2023;183(10):1080-1089.394065400833570104139151182214249268300333352364395427463500524556588625660671
https://doi.org/10.1001/jamainternmed.2023.3300.46336540083386085126153166194215252291307320359382421448482514527559591628661683700733792826841880902937959394066400833895130170183219253286321333369402436472485