NEUROLOGIE PRO PRAXI / Neurol. praxi. 2025;26(5):436-442 / www.neurologiepropraxi.cz 436 Z HISTORIE NEUROLOGIE Koloniální Brit z Denmark Hill: Charles David Marsden (1938–1998) Koloniální Brit z Denmark Hill: Charles David Marsden (1938–1998) prof. MUDr. Petr Kaňovský, CSc., FEAN Neurologická klinika a Centrum klinických neurověd Lékařské fakulty Univerzity Palackého v Olomouci a Fakultní nemocnice Olomouc Charles David Marsden (1938–1998) byl britský neurolog, jeden ze zakladatelů subspecializace „movement disorders“, pro kterou se v češtině používá spíše termín „extrapyramidová onemocnění“. Vystudoval lékařskou fakultu u nemocnice Sv. Tomáše v Londýně a započal svou kariéru v neurologické nemocnici na Queen Square. Brzy ale změnil místo a stal se lékařem v jiném trustu NINDS, v Maudsley and Bethlem Royal Hospital a v King´s College University Hospital, kterým se pro jejich londýnskou lokaci zkráceně přezdívalo „Denmark Hill“. Zde vybudoval pracoviště, které se na dlouhou dobu stalo etalonem v oblasti evropského neurovědního výzkumu; Marsdenovy laboratoře na Windsor Walk se intenzivně věnovaly experimentální a klinické neurofarmakologii, neurofyziologii, neuropsychologii a neuropatologii. Koncem osmdesátých let byla již veleúspěšnému Marsdenovi nabídnuta pozice šéfa firmy v The National Hospital for Neurology and Neurosurgery v Londýně, afiliované k londýnské univerzitě, a Marsden se vrátil tam, kde jeho kariéra začala. Jak na Denmark Hill, tak i na Queen Square vytvořil Marsden inspirující prostředí, kam se neurologii a neurovědy jezdili učit rezidenti a „fellows“ z celého světa. V roce 1995 byl jmenován děkanem univerzitního Institute of Neurology. Poté, co odsloužil celý tříletý „term“, si vzal roční „sabbatical“, který hodlal strávit v NHS v Bethesdě. Po čtyřech týdnech, které tam strávil, zemřel v USA 29. září 1998 nečekanou koronární smrtí. Klíčová slova: Charles David Marsden, dystonie, řízení motoriky. A Colonial Briton from Denmark Hill: Charles David Marsden (1938–1998) Charles David Marsden (1938–1998) was a British neurologist, one of the founders of the subspeciality of movement disorders for which the Czech language prefers to use the term “extrapyramidal diseases”. He graduated from St Thomas’s Hospital Medical School in London and began his career at Queen Square Neurological Hospital. However, he soon changed jobs and became a doctor at another NHS trust, Maudsley and Bethlem Royal Hospital and King’s College Hospital, which were nicknamed “Denmark Hill” due to their location in London. Here, he established a centre that became the benchmark in the field of European neuroscience research for a long time; Marsden laboratories at Windsor Walk were deeply involved in experimental and clinical neuropharmacology, neurophysiology, neuropsychology, and neuropathology. In the late 1980s, the highly successful Marsden is offered the position of head of The National Hospital for Neurology and Neurosurgery in London, affiliated with University College of London (UCL), and Marsden returns to where his career began. At both Denmark Hill and Queen Square, Marsden created an inspiring environment where residents and fellows from all over the world kept coming to study neurology and neuroscience. In 1995, he was appointed dean of the UCL Institute of Neurology. After completing his three-year term, he took a one-year sabbatical, which he planned to spend at the NINDS in Bethesda. After having spent four weeks there, he died unexpectedly from coronary disease on 29 September 1998. Key words: Charles David Marsden, dystonia, motor control. DECLARATIONS: Declaration of originality: The manuscript is original and has not been published or submitted elsewhere. Ethical principles compliance: The authors attest that their study was approved by the local Ethical Committee and is in compliance with human studies and animal welfare regulations of the authors’ institutions as well as with the World Medical Association Declaration of Helsinki on Ethical Principles for Medical Research Involving Human Subjects adopted by the 18th WMA General Assembly in Helsinki, Finland, in June 1964, with subsequent amendments, as well as with the ICMJE Recommendations for the Conduct, Reporting, Editing, and Publication of Scholarly Work in Medical Journals, updated in December 2018, including patient consent where appropriate. Conflict of interest: Not applicable. Consent for publication: Not applicable. Cit. zkr: Neurol. praxi. 2025;26(5):436-442 Článek přijat redakcí: 10. 6. 2025 Článek přijat k publikaci: 16. 6. 2025 prof. MUDr. Petr Kaňovský, CSc., FEAN petr.kanovsky@fnol.cz
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