721
NEUROLOGIE3418040010757101158205267310370429450493
PRO856804001074591154
PRAXI1031804001074591148201221
/12988040010731
Neurol.1374804001075593139165209227243
praxi.1633804001074672114152170186
2025;26(5):366-3701836804001074487128172185229272295338360375419463508537578619660
/25418040010732
www.neurologiepropraxi.cz460880400107651332012142633073553814284484965465656086586857327828098518919109269661005
3701298020012657113168
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TÉMA733200012657114204274
nové34136001063980117149
možnosti50636001065292123165205238271289
léčby8103600106296196132168
myAstenie99436001065288124158190222264281313
grAvis132336001063772114149166199
antigen34062001094496126148200247298
receptor“).66562001093076119164217248299330365393411
Tato110262001094685116166
terapie129462001093177107153205228274
se159562001093683
používá1705620010952104155195217262307
asi34076001094582104
6471760010948
let54676001092270102
ke67576001094490
zvládání78676001094088111156210255308330
B1143760010951
buněčných1221760010953105157205248300343385437
malignit1685760010978123146168221273296327
a340900010944
v405900010944
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je106790001092269
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i1573900010922
u1615900010951
řady168690001093176129174
autoimunitních188790001094495340104001093181104181232284307338390412454506
chorob.872104001094293145176227281300
U11991040010959
myastenie12791040010977120165202234281333355402
jde1708104001092275123
o18571040010951
tři192910400109306183
studie.340118001093770123178202251272
Jedna655118001093584139193239
studie938118001093771124178202251
zahrnuje1233118001093988141174228281305354
upravené16301180010951106139186232279333382
T3401320010945
buňky4121320010952103154197244
namířené682132001095195172194226272324371
proti1079132001095283133164185
maturačnímu12911320010976120151202232277318369391468519
antigenu1836132001094495125147340146001095096146196
B5521460010948
buněk6161460010952102152197240
(BCMA),872146001092574126199254279296
(fáze118414600109265195134180
II,138014600109214362
NCT04146051),14581460010960112160205253294335383430476518538555
druhá214062001095283135187232
potom2399620010953105136187265
proti269162001095384135167189
MuSK2907620010974126171221
protilátce315562001095384135167189211256287329375
(fáze35576200109265298139186
I,377062001092242
NCT05451212)2140760010959111158204249295340382421463503526
a2682760010943
poslední,2744760010951101136157202254303324343
která310376001094274118148191
je331076001092267
také339376001092973115159
teprve356876001092974125154200244
ve214090001094489
fázi225590001092671111133
I2414900010921
(NCT05828225)245590001092685139187233279326371418463510557582
pracuje306390001095182126167218240286
s3375900010936
CD193430900010953113156198
CAR3654900010952110159
T21401040010945
buňkami.22041040010951101151194238313335354
Od22801180010962115
roku2422118001093080124175
2017,2624118001094693136177188
kdy2839118001094293137
byly3003118001095195118161
publikovány31921180010951102154177199242292336381432474
výsledky36931180010943902140132001093658105158202249
studie2416132001093668119172194241
REGAIN,2685132001094895154211234295315
došlo30281320010951102139162213
nejen3268132001095198121168219
k35151320010942
vývoji3578132001094491139189212235
dalších2140146001095196119156178220271
účinných2439146001095092114166217260301352
léků,2819146001092168113164185
ale3031146001094467114
i31721460010922
k32151460010942
významnému3279146001094391133185230307358405483534
rozvoji394062001092978117163211233255
poznání4212620010951101139190233283305
mnoha4534620010974124174224268
aspektů481962001094378130176219251301
této513762001092974105154
závažné530862001093883125169209259305
choroby.394076001094194147179232286331348
Vývoj431776001095298148199223
nových4569760010951104150198241293
léků489176001092270116169
tak508976001093077122
stimuluje52407600109377093172224248300324373
zpřesňování394090001093991122168205255306350395446468
a4428900010943
prohlubování449290001095182132184206257309361404449500522
informací50349000109217299150181258302344366
např.542090001095094146177192
z39401040010938
oblasti39981040010949101124168204235256
patofyziologie,4272104001095195125174201248289311361383434485507553571
klinimetrie486110400109426586137158233280310341363408
či5287104001094061
epidemiologie.53651040010945971191712173940118001097698149172224276299346365
Je4333118001093380
ovšem4441118001095094131178255
otázkou,4723118001095081127167211261313333
kdy5084118001094294138
a52501180010943
v53141180010944
jakém5379118001092267111156233
rozsahu3940132001093082123163209262314
se4283132001093785
tyto4396132001093179114166
nové45901320010951104149196
léky4815132001092270115163
dostanou50071320010952105143176222275328381
k54161320010943
pacientům.54821320010952993940146001094062109160190241317337
LITERATURA341169001234978134189250318368438498567
1.34018600853648
Bril404186008335577288
V,50718600833645
Drużdż56818600834567105134172202
A,78518600834155
Grosskreutz85618600834466103130156186208243280303334
J,120618600832436
et125818600833456
al.13301860083324760
Safety14061860083326584118141174
and159618600833270109
efficacy1721186008334537088120153185219
of195618600833756
rozanolixizumab3401960083205684116153190205219249264292329385417455
in80619600831551
patients8691960083387091105139176197223
with11041960083506486123
generalised123919600833771108142162194209223248282320
myasthenia157119600835686118143165202236273287318
gravis190119600833858903402060083314772
(MycarinG):42520600831871102133166186202239283301313
a750206008332
randomised,7972060083205390128166224238264298337350
double-blind,115920600833876113152167201224264279294331370382
placebo-controlled,155320600833954861181511892282512843203583794004373402160083153065104117
adaptive47121600833170103142164179212246
phase73121600833877109136171
3915216008335
study.9632160083265088127159169
Lancet114521600832964101130159181
Neurol.133721600834373109130164179193
2023;22:383-394.154321600833468101136147182217230265299333355387421456469
2.34022600853652
De41222600834581
Bleecker5132260083365186122155185219240
JL,7742260083245670
Remiche86422600833671129144176214249
G,113322600834458
Alonso-Jiménez12112260083415795133160198222243258316351389424454
A,168522600834156
et176122600833456
al.18382260083324760
Recommendations19182260083367134023600833168126184219257296329350366404442469
for8242360083195678
the9172360083226095
management102823600835789127160199234292327365386
of143023600833756
myasthenia150223600835788121148171209244282297329
gravis18472360083385992124139165
in34024600831553
Belgium.4082460083357086125140178235249
Acta6722460083417296129
Neurol.81724600834479117138175191204
Belg.10372460083346479115128
2024;124:1371-1383.118124600833468101133145175205237249279309341373392423453487521533
3.34025600853651
Dewilde40725600834581132147163202236
S,65925600833346
Phillips7202560083367388103118133172199
G,93525600834457
Paci10082560083356799114
S,113825600833345
et119925600833456
al.12712560083324860
People134725600833569108147163198
Diagnosed15612560083456193132170208235270309
with18862560083516689127
Myasthenia34026600835486119145169207242280295327
Gravis6852660083446598130146172
have87526600833770101135
Lower102826600833269120155176
health-related122226600833772104120142180203225259274307328362402
quality164226600833875108123138160194
of185426600833757
life1929266008315304983
and34027600833270109
Need46427600834580115155
More63427600835593115149
Medical79827600835590129144176209225
and103827600833270109
Caregiver11622760083407394128168183216250271
Help14482760083458095134
in159727600831553
Comparison166527600834077136175208229245271309347
to34028600832157
the4102860083215892
General51528600834377115149169202217
Population:74428600833470109146161193214229266303315
Analysis107128600834178109124155182196221
of130428600833756
Two137228600833278115
Observational149928600834786112146166200233254268306343375390
Studies.190128600833252893402960083385388115128
Adv.48429600834179112122
Ther.6212960083316898119130
2023;40:4377-4394.76329600833468101136147182218231265298330365383420452486522534
4.34030600853651
Farmakidis4093060083326283141174204220259274300
C,72730600834053
Pasnoor7983060083356793131170208230
M,104630600835467
Dimachkie113130600834661119151183221251268303
MM,1451306008355110123
Barohn15923060083356890127165203
RJ.18133060083356275
Treatment1906306008332498334031600833254112147185206
of56231600833756
Myasthenia63431600835485118145168206241279295326
Gravis.9763160083446598130145172185
Neurol.117731600834373109130165180193
Clin.13823160083385367104117
2018;36:311-337.151131600833468100131143178213225260291319338370403435441
5.34032600853549
Gilhus4003260083435872108144169
NE.5803260083447688
Treatment6793260083324881112132189222259279
considerations96932600833167104129142180213233265286300336373399
in137832600831551
myasthenia144032600835786118143165202236272286317
gravis17683260083385889119134159
for19383260083185475
the3403360083225993
pregnant4473360083396093132169201238259
patient.7203360083397192107141178199212
Expert94533600833365104139159183
Rev.114233600833570101110
Neurother.126733600834372108128162182217247267277
2023;23:169-177.155733600833468100134145179213224253283316339369398432437
6.34034600853652
Gilhus4133460083446076114152179
NE,6133460083457992
Andersen72634600834180120155177204240279
H,102534600834558
Andersen110434600834180120155177205240279
LK,14043460083316883
et150734600833557
al.15853460083324861
Generalized166734600834480119155176210226241270305345
myasthenia34035600835889122149172210246284299332
gravis6923560083386093125141167
with8803560083506689127
acetylcholine10283560083326498121155171203241280296311349385
receptor14333560083215588122162184221243
antibodies:16973560083327092107146186225241276303315
A340366008341
guidance3963660083387691130162200232266
for6773660083195678
treatment.7703660083224378109131189224262284297
Eur.1083366008331668697
J.119336600832336
Neurol.124236600834373109130165180193
2024;31:e16229.144736600833468101133145180211219254284315348383417428
7.34037600853644
Habib39737600834476115130169
AA,5783760083418497
Zhao68837600833875107145
C,84537600834053
Aban91037600834180113150
I,107337600831527
et111337600833355
al.11813760083324759
Safety12533760083326584118140173
and143937600833169107
efficacy1559376008334527087119152183217
of178837600833756
satralizumab18573760083265980101134340386008315305997155187227
in58038600831553
patients6463860083397293109143182203231
with8903860083516689127
generalised103138600833873111146167200215230256291331
myasthenia137538600835888121148171209244282297329
gravis17183860083385992124139166
(LUMINESCE):1897386008319509334039600835672119153189231265285298
a660396008332
randomised,7093960083215595135175235251278314355369
double-blind,109939600833979118159176212236277294310349390403
multicentre,152439600835998114137153186221261283306341354
placebo-controlled1899396008340579034040600833165104143166200237275297318356371387421461
phase81640600833977110136171
31002406008334
trial.1052406008321435890106119
Lancet118340600832964101130159181
Neurol.137640600834373109130165180193
2025;24:117-127.158240600833468101136147182214226255283313331362392425431
8.34041600853652
Howard40741600834482133166187226
JF,6474160083255863
Bresch7254160083365791118150188
S,92841600833245
Genge98841600834479117156191
A,119441600834155
et126441600833456
al.13354160083314760
Safety14104160083326584118141174
and159941600833270109
efficacy1723416008334527088120153185218
of195641600833757
zilucoplan340426008328446098130168208224257295
in65642600831553
patients7304260083397395110145184206234
with9854260083516789128
generalised113442600833874112148169203218234260296336
myasthenia149142600835789122149172211247285300333
gravis18454260083386093125141168
(RAISE):214018600831956100116149182203215
a2377186008332
randomised,24251860083215595135174234250277313353367
double-blind,281318600833978117157174210234275292307346386400
placebo-controlled,32341860083395689122157197237261296334373396418456473489524565578
phase214019600833977109136171
32326196008335
study.23761960083264987126158168
Lancet256019600832964101130159181
Neurol.275319600834373109130165180193
2023;22:395-406.295819600833468101136147182217230265298332354391427462476
9.214020600853649
Howard220220600834482133166187224
JF,24392060083245763
Bril2515206008335567287
V,261520600833544
Vu267220600833572
T,275720600833241
et281120600833456
al.28802060083314759
Safety,29522060083336584118141174184
efficacy,3149206008333526987119152184217227
and338920600833169108
tolerability35102060083215874109130162201217232247269303
of214021600833756
efgartigimod22082160083345290122142166181219234291329367
in258821600831451
patients26522160083387092106140178199226
with28902160083506587125
generalised302721600833872109144165197212226252286325
myasthenia336421600835787120146168206240277292323
gravis3700216008337589021402260083324773
(ADAPT):222622600831960105145180214236248
a2487226008331
multicentre,253322600835895110133148180213251273294328340
randomised,28862260083205391130168226241267302341354
placebo-controlled,32532260083395486118152191230253287323362383405442457472507547559
phase214023600833977109136171
32326236008335
trial.2376236008321435991106119
Lancet251023600832964101130159181
Neurol.270323600834373109130165180193
2021;20:526-536.290923600833468101133141176210223258291325348382415450463
10.21402460085377492
Howard225724600834587141177202243
JF,25262460083246169
Utsugisawa262124600834570101142184202231268322358
K,300524600833553
Benatar308424600833674116151176212236
M,334624600835572
et344324600833560
al.35292460083335166
Safety36212460083337091129154191
and214025600833272113
efficacy2273256008334557997131166200236
of252925600833758
eculizumab260725600833469109126143174215275309351
in297725600831555
anti-acetylcholine30522560083327295113137171206241266302320354394434452469509546
receptor3618256008321579212816921402660083226185
antibody-positive22502660083337397115157198240275299342383413430455472508544
refractory28192660083215879104140174201241265301
generalised314526600833976117154178214231249277315357
myasthenia35272660083589112715618222226021402760083385589
gravis22542760083396298132150178
(REGAIN):24572760083195793139184201249270284
a2766276008332
phase281827600833980115143181
3,302427600833448
randomised,30972760083215697138179240257286323365380
double-blind,35022760083387911916117921624228421402860083153272113128
placebo-controlled,22862860083395791125161202243269305344384408431471489506543584599
multicentre290328600835898115139157191227267291314350
study.32712860083275292133167179
Lancet346928600832966105137168191
Neurol.3676286008343751132140296008320577489
2017;16:976-986.224629600833470104136148180213228265300334359396434471486
11.21403060085366577
Mahic223030600835486124139170
M,241330600835467
Bozorg249330600833573101138159197
A,270330600834054
Rudnik277030600833572111149163193
J,297630600832435
Zaremba30243060083387091125182221254
P,329030600833540
Scowcroft334230600833264101152183204241260284
A.363930600834155
Treatment37073060083324983214031600833253111145183204
patterns23573160083387192116150171209235
in260531600831452
myasthenia266931600835788120146169207242279294326
gravis:30073160083385992123138164177
A3196316008341
United32523160083438195118151190
States34553160083325385107140167
health363431600833872104119141179
claims2140326008331477994152178
analysis.233332600833270102118149177191217231
Muscle258032600835389113142156187
Nerve.27793260083437394126156169
2023;67:297-305.296032600833468101136147183216226261295328347379414448460
12.21403360085356681
Mantegazza223333600835385122143175214245274304337
R,258233600833448
Vanoli264233600833565102139154168
F,282233600833238
Frangiamore28723360083315082119157172203259296317350
R,323433600833548
Cavalcante329433600833971102134148179211248269302
P.360833600833439
Complement36593360083397513221403460083395589147182220242
Inhibition24003460083155391106145160183198236274
for26923460083195678
the27883460083215994
Treatment29003460083335084116138196231269290
of320834600833757
Myasthenia328334600835485118145168206241279295327
Gravis.36273460083446699130146172186
ImmunoTargets214035600831571127162199235263294315349380401426
Ther.25783560083316899119130
2020;9:317–331.272135600833468101135148184197232263292325357390421430
13.21403660085366883
Mevius224136600835490122138175201
A,246036600834156
Jöres25343660083246284118145
L,269736600833145
Biskup27603660083355177107145184
J,296236600832436
et301736600833456
al.30913660083324760
Epidemiology31693660083337287126161219234272288326366398
and358536600833270109
treatment37123660083224377214037600833255114150189211
of237337600833857
myasthenia245237600835890123151175214250289304337
gravis:28103760083396195127143170183
a3015376008332
retrospective30633760083215679101139167207243277301317351386
study34703760083275189129162
using36543760083376480119159
a2140386008332
large21873860083154768106141
insurance23463860083145279116137170208240274
claims2637386008331477994152178
dataset28333860083387092124151186208
in305938600831452
Germany.312938600834379100159191229260270
Neuromuscul.341638600834580117139176234272298330368383396
Disord.21403960083456187125147185198
NMD.235439600834396140153
2023;33:324–333.252239600833468101136147182215227262294326364396429462474
14.21404060085366984
Nair22384060083457792113
SS,23654060083326477
Jacob24564060083245688125165
S.263440600833346
Novel269340600834583115149165
Immunotherapies287240600831472130168206244266304339360393432448483509
for33954060083185677
Myasthenia348640600835486119145168207242280295327
Gravis.21404160083446598130146172185
ImmunoTargets234141600831571127162199235263294315349380401426
Ther.27794160083316899119130
2023;12:25-45.292141600833468101136147177207220255290312349381393
15.21404260085366883
Nowak224042600834583134167197
RJ,24544260083356274
Coffey25444260083407797116150182
CS,27424260083407487
Goldstein28464260083438298137163186220235273
JM,31364260083247992
et324542600833456
al.33174260083324860
Phase339442600833573105131166
23577426008334
Trial3628426008332496597112
of375742600833756
Rituximab39401860083355173111143158216248287
in424318600831452
Acetylcholine431018600834173107129163179211249287303318356391
Receptor471618600833570103137176198235256
Antibody-Positive498818600834179100116155194233265287324361387402425440473507
Generalized55101860083447939401960083387394127142157186220260
Myasthenia421719600835586119146169207242280295327
Gravis:45621960083446598130146172184
The476419600833372107
BeatMG488919600833570102124179223
Study.51301960083335492131163173
Neurology.532119600834373109130165180215252281292
2022;98:e376-e389.394020600833468101136148184219231265300332364387424458493527538
16.39402160085356884
Pane403621600833566103138
C,418621600833952
Di425021600834560
Stefano43222160083335386105138175212
V,454721600833543
Cuomo460321600833975112170207
N,482321600834456
et489221600833355
al.49592160083324759
A5030216008341
real-life50862160083205385100121137152170204
experience530321600833364103138158174208245277310
with39402260083516689127
eculizumab408022600833466104119134164202260292331
and442422600833270109
efgartigimod45462260083345392124145170185224239297335375
in493422600831452
generalized499922600833873111146167200216231260294333
myasthenia53452260083588812114817120924439402360083385385
gravis40402360083385992124139166
patients.42212360083397193109143181203231244
J.448123600832437
Neurol.453123600834273109129164179192
2024;271:6209-6219.473823600833468101133145180213245254289323357392415453486517548559
17.39402460085366876
Piehl40322460083355084123138
F,418624600833238
Eriksson-Dufva4240246008333536999128155193231254301339359394427
A,468224600834156
Budzianowska475324600833674113142158190228266317344374407
A,517624600834155
et524724600833456
al.53192460083324860
Efficacy5395246008333516986119151184217
and394025600833168106
Safety40582560083326482116137170
of424025600833655
Rituximab43072560083354971108138153209241279
for45982560083185575
New-Onset468525600834478128150198236261295317
Generalized501425600834377114148168200215229258291329
Myasthenia53552560083548411614216420123539402660083375182
Gravis:40342660083436496126141166178
The422426600833270104
RINOMAX43402660083344993140194234273
Randomized462526600833567104141178235250278311349
Clinical49862660083395468104119150182196
Trial.5194266008332486394109121
JAMA532726600832359111148
Neurol.5485266008342721073940276008320557083
2022;79:1105-1112.403627600833468101136148181214228257285316351373403431459489501
18.39402860085366985
Polák40442860083357288120150
P,421228600833640
Penka427028600833669107137171
M,445928600835468
Smejkal454528600833390125140170204219
P,478328600833539
et484128600833456
al.49152860083324760
Treatment49932860083335084116138196231269291
with53022860083516689127
rituximab5447286008321365997128144394029600835789128
as408029600833258
an415129600833169
opportunity423329600833776115153175199236274289311344
for45902960083185577
the46792960083226094
prevention47862960083385993125159197218233270308
of510729600833756
infectious51762960083145270104137161176213251277
complications.54652960083316812639403060083395570102134156171209248274288
Vnitř42433060083357084105125
Lék.43813060083295887101
2016;62:398-405.449530600833468100131144179213225260294329351388424458470
19.39403160085366982
Saccà40433160083326598128161
F,422531600833238
Pane428331600833567105140
C,444431600834053
Espinosa45173160083336099115152191217251
PE,47883160083356781
et488931600833456
al.49663160083314760
Efficacy5046316008333506886118151183217
of528331600833757
innovative53603160083155390129161194215231394032600833266
therapies40213260083226095116149189204239266
in430232600831553
myasthenia437032600835888121148171209244282297329
gravis:47153260083385992124139166178
A4909326008340
systematic49653260083265885109142200233254270302
review,52823260083215587103138189199
meta-analysis54973260083579239403360083225477109147179195227254268295
and425033600833270109
network43743360083387395148186207238
meta-analysis.462733600835793115148170202240273288320347362388401
Eur.5044336008331668697
J.515433600832336
Neurol.520333600834373109130165180193
2023.540833600833468101136148
20.39403460085367388
Vu404934600833673
T,414334600833342
Meisel420634600835591106133168184
A,441134600834256
Mantegazza448834600835588127149183223256286318352
R,486134600833650
et493234600833457
al.50103460083324861
Terminal50923460083336485145160199231247
Complement536034600834078137177193228394035600835792130152
Inhibitor41053560083145290105144160182219241
Ravulizumab43593560083356899137153168197235292325364
in473635600831452
Generalized480135600834479117152173206222237266300339
Myasthenia515335600835486119145168206241279294326
Gravis.549235600834465983940366008332477387
NEJM404336600834374100153
Evid.42093660083316075110124
2022;434536600833468101136148
1:450936600833442
EVIDoa2100066.45673660083327086132171204238270301337373409445458
21.39403760085367082
Wiendl404037600835774108146185201
H,425837600834557
Abicht43333760083418096128166188
A,453837600834155
Chan461137600834078110148
A,477737600834155
et485037600833456
al.49243760083314760
Guideline50013760083448297136171187202239274
for52933760083195678
the53883760083226095
management550137600835790394038600833870109144202237275296
of425338600833857
myasthenic432738600835788121147171209244282297329
syndromes.46733860083265997136158195253288315329
Ther.501938600833271106128138
Adv.517438600834179112122
Neurol.531338600834580117139176192205
Disord.55323860083445939403960083245980114128
2023;16:17562864231213240.408139600833468101136147177209221251280313347381414450486519553584614646676708740776789
22.39404060085377593
Wolfe406140600835998115136172
GI,42614060083456276
Kaminski436540600833672132149189217249266
HJ,46594060083467386
Aban477340600834284119159
IB,49604060083155367
et505540600833559
al.51424060083335064
Randomized523440600833671111152193254270301337379
Trial3940416008333516799115
of407641600833857
Thymectomy415441600833373104164200233258295354386
in456141600831553
Myasthenia463541600835587121148172210246285300333
Gravis.498941600834466100132148175189
N.519941600834357
Engl.527341600833268104120133
J.542341600832438
Med.547841600835385121135
2016;375:511-522.394042600833468100131143178211243254290321348367401434469481
25.–27.8516310016894187231312397487519
11.14106310016894183231
202616816310016895187277369
|21226310016843
Praha22386310016899154236326408
39.263518005742605106905300042760
český83053000427175365510680863
a176353000427210
slovenský204453000427151217412586771960110412741457
neurologický82956200427201393590728910992118813971478164118412050
sjezd294656200427159239431597791
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