Neurol. praxi. 2013;14(1):51-53

Orolingual angioedema - complication of acute stroke treatment with systemic thrombolysis

MUDr.Zdeněk Kadaňka ml., MUDr.Stanislav Peška, prof.MUDr.Josef Bednařík, CSc.
Neurologická klinika LF MU a FN Brno

The aim of this study was to investigate the incidence, the severity and possible complications of orolingual angioedema (OA) in patients

treated by intravenous trombolysis in the University Hospital, Brno since 2004 till the end of 2011.

Patients and methods: This study is the retrospective analysis of 290 patients with acute ischemic stroke treated by recombinant tissue plasminogen

activator. The average age was 67 years, 59 % males and 41 % females. All the patients data were sent to the international SITS register.

Results: There were three cases of OA (1.03 % of all patients). The anaphylactoid reaction was mild in all cases, with no need of intubation

or life threat.

Keywords: orolingual angioedema, anaphylaxis, intravenous thrombolysis

Published: March 1, 2013  Show citation

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Kadaňka Z, Peška S, Bednařík J. Orolingual angioedema - complication of acute stroke treatment with systemic thrombolysis. Neurol. praxi. 2013;14(1):51-53.
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    References

    1. Bennett WR, Yawn DH, Migliore PJ, Young JB, Pratt CM, Raizner AE, Roberts R, Bolli R. Activation of the complement system by recombinant tissue plasminogen activator. J Am Coll Cardiol 1987; 10 (3): 627-632. Go to original source... Go to PubMed...
    2. Cugno M, Cicardi M, Colucci M, Bisiani G, Merlini PA, Spinola A, Paonessa R, Agostoni A. Non neutralizing antibodies to tissue type plasminogen activator in the serum of acute myocardial infarction patients treated with the recombinant protein. Thromb Haemost 1996; 76(2): 234-238. Go to original source... Go to PubMed...
    3. Diserens K, Vuadens P, Michel P, Reichhart M, Herrmann FR, Arnold P, Bogousslavsky J, Ghika J. Acute autonomic dysfunction contralateral to acute strokes: a prospective study of 100 consecutive cases. Eur J Neurol 2006; 13(11): 1245-1250. Go to original source... Go to PubMed...
    4. Engelter ST, Fluri F, Buitrago-T?llez C, Marsch S, Steck AJ, Rüegg S, Lyrel PA. Life-threatening orolingual angioedema during thrombolysis in acute ischemic stroke. J Neurol 2005; 252(10): 1167-1170. Go to original source... Go to PubMed...
    5. Hill MD, Barber PA, Takahashi J, Demchuk AM, Feasby TE, Buchan AM. Anaphylactoid reactions and angioedema during alteplase treatment of acute ischemic stroke. CMAJ 2000; 162(9): 1281-1284. Go to PubMed...
    6. Hill MD, Buchan AM. Thrombolysis for acute ischemic stroke: results of the Canadian Alteplase for Stroke Effectiveness Study. CMAJ 2005; 172(10): 1307-1312. Go to original source... Go to PubMed...
    7. Hill MD, Lye T, Moss H, Barber PA, Demchuk AM, Newcommon NJ, Green TL, Kenney C, Cole-Haskayne A, Buchan AM. Hemiorolingual angioedema and ACE inhibitor use after alteplase treatment of stroke. Neurology 2003; 60(9): 1525-1527. Go to original source... Go to PubMed...
    8. Jahnke HK. An 89 year-old woman with angioedema during t-PA infusion for acute ischemic stroke. J Emerg Nurs 2003; 29(2): 142-144. Go to original source... Go to PubMed...
    9. Krmpotic KR, Fernandes CM. Anaphylactoid reaction to recombinant tissue plasminogen activator. Eur J Emerg Med 2007; 14(1): 60-61. Go to original source... Go to PubMed...
    10. Laubinger R, Guthke K, Erdmann U, Klein U. Angioneurotic orolingual edema associated with the use of rt-PA following a stroke. Anaesthesist 2007; 56(10): 1024-1027. Go to original source... Go to PubMed...
    11. Molinaro G, Gervais N, Adam A. Biochemical basis of angioedema associated with recombinant tissue plasminogen activator treatment: an in vitro experimental approach. Stroke 2002; 33(6): 1712-1716. Go to original source... Go to PubMed...
    12. Ottomeyer C, Hennerici MG, Szabo K. Raising awareness of orolingual angioedema as a complication of thrombolysis in acute stroke patients. Cerebrovasc Dis 2009; 27(3): 307-308. Go to original source... Go to PubMed...
    13. Park IS, Cho AH, Lee SJ, Kim JS, Lee KS, Kim YI. Life-threatening anaphylactoid eaction in an acute ischemic stroke patient with intravenous rt-PA thrombolysis, followed by successful intra-arterial thrombolysis. J Clin Neurol 2008; 4(1): 29-32. Go to original source... Go to PubMed...
    14. Polák M, Korsa J, Šedivá A, Šírek J. Angioedém po podání rt-PA méně častá komplikace systémové trombolýzy. Cesk Slov Neurol N 2011; 74(3): 376-377.
    15. Rafii MS, Koenig M, Ziai WC. Orolingual angioedema associated with ACE inhibitor use after rt-PA treatment of acute stroke. Neurology 2005; 65(12): 1906. Go to original source... Go to PubMed...
    16. Reed BR, Chen AB, Tanswell P, Prince WS, Wert RM Jr, Glaesle-Schwarz L, Grossbard EB. Low incidence of antibodies to recombinant human tissue-type plasminogen activator in treated patients. Thromb Haemost. 1990; 64(2): 276-280. Go to original source... Go to PubMed...
    17. Rudolf J, Grond M, Prince WS, Schmülling S, Heiss WD. Evidence of anaphylaxy following alteplase infusion. Stroke 1999; 30(5): 1142-1143. Go to original source... Go to PubMed...

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