Neurol. praxi. 2015;16(4):227-230
Deliberation about diagnostic overlaps of pregabalin treatment
- Centrum pro poruchy spánku Nemocnice České Budějovice, a.s.
Pregabalin(PGB) is a medical substance usefull in more situations. Initialy was used as anticolvulsant medication, but it is used in therapy of neuropatic pain too. Neuropatic pain unlike to somatic pain arises due to gained hypersensibility and hyperexcitability of neurons. PGB increases main inhibitor GABA and decreases quantity of excitate neurotransmitters, which cause decreasing of interneuronal communication. At Generalised anxiety disorder (GAD) is used this effectiveness similarly, where also exhibitions of excessive interneuronal communication is common. PGB in sleeptime increases quantity of NREM3 and simultaneously decreses REM a NREM1, prevents reduction of intracortical, but spinal inhibition too – RLS,PLMD. Inhibition of interneuronal communication is happening at all levels of peripheral and central nervous system. We can involve Epilepsy, also GAD, neuropathy, RLS and PLMD too. Mutual diagnostic overlaps have good response to the treatment with PGB. There is considering synergic effect.
Keywords: pregabalin, neurophy, GAD, RLS, PLMD, interneuronal connectivity
Published: September 19, 2015 Show citation
References
- Allen RP, Chen C, Garcia-Borreguero D, Polo O, DuBrava S, Miceli J, Knapp L, Winkelman JW. Comparison of pregabalin with pramipexole for restless legs syndrome. N Engl J Med 2014; 370: 621-631.
Go to original source... - Coleman P. Pregabalin versus pramipexole for restless legs syndrome; N Engl J Med May 22, 2014; 370: 2049-2051. Go to original source...
- MacFarlane BV, Wright A, O'Callaghan J, Benson HAE. Chronic neuropathic pain and its control by drugs. Pharmacol Ther 1997; 75: 1-19. Go to original source...
- Garcia-Borreguero D, Larrosa O, Williams AM, Phil M, Albares J, Pascual M, Palacios JC, and Fernandez C. Treatment of restless legs syndrome with pregabalin. A double-blind, placebo-controlled study. Neurology June 8, 2010; 74(23): 1897-1904. Go to original source...
Go to PubMed... - Garcia-Borreguero D, Patrick J, DuBrava S, Becker PM, Lankford A, Chen C, Miceli J, Knapp L, Allen RP. Pregabalin versus pramipexole: effects on sleep disturbance in restless legs syndrome. Sleep 2014; 37(4): 635-643. Go to original source... Go to PubMed...
- Kasper S, Herman B, Nivoli G,Van Ameringen M, Petralia A, Mandel FS, Baldinetti F, Bandelow B. Efficacy of pregabalin and venlafaxine-XR in generalized anxiety disorder: results of a double-blind placebo controlled 8-week trial. Int Clin Psychopharmacol 2009; 24(2): 87-96. Go to original source... Go to PubMed...
- Mastík J. Antikonvulziva v terapii bolesti - mechanizmy účinku. Neurol. prax, 2008; 1: 39-43.
- Roth T, Arnold LM, Garcia-Borreguero D, Resnick M, Clair AG. A review of the effects of pregabalin on sleep disturbance across multiple clinical conditions. Sleep Med Rev. 2014 Jun; 18(3): 261-271. Go to original source...
- Švestka J. Pregabalin - nově dostupné anxiolytikum pro léčbu generalizované úzkostné poruchy; Farmakoterapie 2012(3)..