Neurol. praxi. 2020;21(4):319-321 | DOI: 10.36290/neu.2020.036

Eye of tiger sign in patient with extrapyramidal syndrome - unique case report

MUDr. Martin Daniš, MUDr. Juraj Cisár, MUDr. Georgi Krastev, PhD.

Neurologické oddelenie, Fakultná nemocnica Trnava

In this paper we present a case of a 39-year-old patient, who presented with a 4-year history of gradually worsening symptoms of uncontrolled movements of the right limbs, walking difficulties and unsteadiness pulling her to the right. During clinical examination we observed choreoathetoid movements and dystonic posture of the head and the limbs on the right side of the body, rigidity of the right limbs, postural and resting tremor of the hands, positive Romberg's and Babinski sign on the right. On brain MRI we could see pathological hypodensity zones symmetrically in the region of globus pallidus bilaterally - typical for the eye of the tiger sign that corresponded to a neurodegenerative metabolic disease with brain iron accumulation (NBIA). On the molecular genetic examination of the PANK2 gene we identified a pathogenic variant c.1583C> T (p.Thr528Met) in the PANK2 gene in the homozygous line. According to these results we confirmed a diagnosis of pantothenate kinase associated neurodegeneration (PKAN).

Keywords: NBIA (neuron brain iron accumulation), PKAN (pantothenate kinase-associated neurodegeneration), extrapyramidal syndrome, dystonia.

Received: February 2, 2020; Revised: March 31, 2020; Accepted: April 1, 2020; Published: September 8, 2020  Show citation