Neurol. praxi. 2024;25(5):348-350 | DOI: 10.36290/neu.2024.007

Takotsubo syndrome and central nervous system

prof. MUDr. Petr Toušek, Ph.D., MUDr. Karolína Poledníková
Kardiologická klinika, 3. lékařská fakulta UK a Fakultní nemocnice Královské Vinohrady, Praha

Takotsubo syndrome is defined as a syndrome of acute heart failure that is very often manifested clinically as acute coronary syndrome. Transient left ventricular dysfunction is a characteristic clinical feature. Acute neurological diseases are relatively frequently the triggering factors; thus, it is assumed that it is the central nervous system that plays a significant role in the pathophysiology. The review article aims to provide basic information on Takotsubo syndrome with a focus on the very likely pathophysiological mechanisms in the brain-heart axis.

Keywords: Takotsubo syndrome, central nervous system, pathophysiology, brain-heart axis.

Received: January 22, 2024; Revised: January 22, 2024; Accepted: January 30, 2024; Prepublished online: January 30, 2024; Published: November 19, 2024  Show citation

ACS AIP APA ASA Harvard Chicago Chicago Notes IEEE ISO690 MLA NLM Turabian Vancouver
Toušek P, Poledníková K. Takotsubo syndrome and central nervous system. Neurol. praxi. 2024;25(5):348-350. doi: 10.36290/neu.2024.007.
Share...
Download citation
  • BibTeX (.bib)
  • Bookends (.ris)
  • EasyBib (.ris)
  • EndNote (.enw)
  • EndNote 8 (.xml)
  • ISI WoS (.isi)
  • Medlars (.medlars)
  • Mendeley (.ris)
  • MODS (.xml)
  • Papers (.ris)
  • RefWorks (.txt)
  • RefManager (.ris)
  • RIS (.ris)
  • MS Word (.xml)
  • Zotero (.ris)
    • Purchase PDF - 60 CZK (2.5 EUR)
    will be unlocked 19.11.2025

    References

    1. Abraham J, Mudd JO, Kapur NK, et al. Stress cardiomyopathy after intravenous administration of catecholamines and beta­‑receptor agonists. J Am Coll Cardiol. 2009;53:1320-1325. Go to original source... Go to PubMed...
    2. Alvarenga ME, Richards JC, Lambert G, Esler MD. Psychophysiological mechanisms in panic disorder: a correlative analysis of noradrenaline spillover, neuronal noradrenaline reuptake, power spectral analysis of heart rate variability, and psychological variables. Psychosom Med. 2006;68:8-16. Go to original source... Go to PubMed...
    3. Biso S, Wongrakpanich S, Agrawal A, et al. Cardiovasc Psychiatry Neurol. 2017;2017:5842182. Go to original source... Go to PubMed...
    4. Burgdorf C, von Hof K, Schunkert H, Kurowski V. Regional alterations in myocardial sympathetic innervation in patients with transient left­‑ventricular apical ballooning (Tako­‑tsubo cardio­myopathy). J Nucl Cardiol. 2008;15:65-72. Go to original source... Go to PubMed...
    5. Burch GE, Meyers R, Abildskov JA. A new electrocardiographic pattern observed in cerebrovascular accidents. Circulation. 1954;9(5):719-723. Go to original source... Go to PubMed...
    6. Dichtl W, Tuovinen N, Barbieri F, et al. Functional neuroimaging in the acute phase of Takotsubo syndrome: volumetric and functional changes of the right insular cortex. Clin Res Cardiol. 2020;109:1107-1113. Go to original source... Go to PubMed...
    7. Ghadri JR, Cammann VL, Jurisic S, et al. A novel clinical score (InterTAK Diagnostic Score) to differentiate Takotsubo syndrome from acute coronary syndrome: results from the International Takotsubo Registry. Eur J Heart Fail. 2017;19:1036-1042. Go to original source... Go to PubMed...
    8. Ghadri JR, Wittstein IS, Prasad A, et al. International expert consensus document on Takotsubo syndrome (part I): clinical characteristics, diagnostic criteria, and pathophysiology. Eur Heart J. 2018;39:2032-2046. Go to original source... Go to PubMed...
    9. Kato K, Di Vece D, Cammann VL, et al., InterTAK Co­‑investigators. Takotsubo recurrence: morphological types and triggers and identification of risk factors. J Am Coll Cardiol. 2019;73:982-984. Go to original source... Go to PubMed...
    10. Ortak J, Khattab K, Barantke M, et al. Evolution of cardiac autonomic nervous activity indices in patients presenting with transient left ventricular apical ballooning. Pacing Clin Electrophysiol. 2009;32(Suppl. 1):S21-S25. Go to original source... Go to PubMed...
    11. Paur H, Wright PT, Sikkel MB, et al. High levels of circulating epinephrine trigger apical cardiodepression in a beta2-adrenergic receptor/Gi­‑dependent manner: a new model of Takotsubo cardiomyopathy. Circulation. 2012;126:697-706. Go to original source... Go to PubMed...
    12. Poledníková K, Kozel M, Línková H, et al. Triggers, characteristics, and hospital outcome of patients with Takotsubo syndrome: 10 years experience in a large university hospital centre. Eur Heart J Supplements. 2023;25:E10-E16. Go to original source... Go to PubMed...
    13. Radfar A, Abohashem S, Osborne MT, et al. Stress­‑associated neurobiological activity associates with the risk for and timing of subsequent Takotsubo syndrome. Eur Heart J. 2021;42:1898-1908. Go to original source... Go to PubMed...
    14. Suzuki H, Matsumoto Y, Kaneta T, et al. Evidence for brain activation in patients with Takotsubo cardiomyopathy. Circ J. 2014;78:256-258. Go to original source... Go to PubMed...
    15. Templin C, Ghadri JR, Diekmann J, et al. Clinical features and outcomes of Takotsubo (stress) cardiomyopathy. N Engl J Med. 2015;373:929-938. Go to original source... Go to PubMed...
    16. Ulrich­‑Lai YM, Herman JP. Neural regulation of endocrine and autonomic stress responses. Nat Rev Neurosci. 2009;10:397-409. Go to original source... Go to PubMed...
    17. Yoshimura S, Toyoda K, Ohara T, et al. Takotsubo cardiomyopathy in acute ischemic stroke. Ann Neurol. 2008;64:547-554. Go to original source... Go to PubMed...

    Return to the content


    Neurology for Practice

    Madam, Sir,
    please be aware that the website on which you intend to enter, not the general public because it contains technical information about medicines, including advertisements relating to medicinal products. This information and communication professionals are solely under §2 of the Act n.40/1995 Coll. Is active persons authorized to prescribe or supply (hereinafter expert).
    Take note that if you are not an expert, you run the risk of danger to their health or the health of other persons, if you the obtained information improperly understood or interpreted, and especially advertising which may be part of this site, or whether you used it for self-diagnosis or medical treatment, whether in relation to each other in person or in relation to others.

    I declare:

    1. that I have met the above instruction
    2. I'm an expert within the meaning of the Act n.40/1995 Coll. the regulation of advertising, as amended, and I am aware of the risks that would be a person other than the expert input to these sites exhibited

    No
    Yes

    If your statement is not true, please be aware
    that brings the risk of danger to their health or the health of others.