Neurol. praxi. 2024;25(5):393-398 | DOI: 10.36290/neu.2023.013

Tuberculoma or tuberculous abscess? - two case studies

MUDr. Šárka Herrmannová1, prof. MUDr. Radoslav Matěj, Ph.D.2, MUDr. Adam Pavličko3, MUDr. Ondřej Sobek, CSc.4, doc. MUDr. Dušan Pícha, CSc.5, MUDr. Michaela May, Ph.D.6, prof. MUDr. Robert Rusina, Ph.D.1
1 Neurologická klinika 3. LF UK a FTN, Praha
2 Ústav patologie a molekulární medicíny 3. LF UK a FTN, Praha
3 Radiodiagnostické oddělení FTN, Praha
4 Laboratoř pro likvorologii a neuroimunologii Topelex, s. r. o., Praha
5 Klinika infekčních nemocí 2. LF UK a FN Bulovka, Praha
6 Neurochirurgická a neuroonkologická klinika 1. LF UK a ÚVN, Praha

Brain tuberculomas and tuberculous abscesses are rare focal manifestations of central nervous system tuberculosis. Their clinical and morphological presentation may mimic brain tumors or bacterial abscesses, and therefore be a source of diagnostic ambiguity. The goal of our presentation is to demonstrate two case reports of patients with a solitary lesion of tuberculous origin, and related diagnostic pitfalls. Despite the decrease in tuberculosis incidence in the Czech Republic, it is obvious that physicians may continue to encounter patients with immunosuppressive therapy and migrants from endemic regions. Regarding their relatively favorable therapeutic outcome, focal tuberculous lesions should be considered in the differential diagnosis of intracerebral expansions.

Keywords: tuberculosis, tuberculoma, tuberculous abscess.

Received: December 27, 2022; Revised: February 21, 2023; Accepted: March 2, 2023; Prepublished online: March 2, 2023; Published: November 19, 2024  Show citation

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Herrmannová Š, Matěj R, Pavličko A, Sobek O, Pícha D, May M, Rusina R. Tuberculoma or tuberculous abscess? - two case studies. Neurol. praxi. 2024;25(5):393-398. doi: 10.36290/neu.2023.013.
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    References

    1. Bathla G, Khandelwal G, Maller VG, et al. Manifestations of cerebral tuberculosis. Singapore Med J. 2011;52(2): 124-131.
    2. Bernaerts A, Vanhoenacker FM, Parizel PM, et al. Tuberculosis of the central nervous system: overview of neuroradiological findings. Eur Radiol. 2003;13(8):1876-1890. doi:10.1007/s00330-002-1608-7. Go to original source... Go to PubMed...
    3. Chaudhary V, Bano S, Garga UC. Central Nervous System Tuberculosis: An Imaging Perspective. Can Assoc Radiol J. 2017;68(2):161-170. doi:10.1016/j.carj.2016. 10. 007. Go to original source...
    4. Garcia­‑Monco JC. Central nervous system tuberculosis. Neurol Clin. 1999;17(4):737-759. doi: 10.1016/s0733-8619(05)70164-x. Go to original source... Go to PubMed...
    5. Gray F, Duyckaerts C, Girolami U. Escourolle and Poirier's Manual of Basic Neuropathology, 5th Edition. Oxford University Press 2013. ISBN-13: 9780190675011. doi: 10.1093/med/9780199929054.001.0001. Go to original source...
    6. Haddadian K, Rezaei O, Samadian M. Multiple Brain Tuberculomas And Role Of Open Brain Biopsy: A Case Report And Review. Internet Jf Infect, DiS. 2005;4(1). Dostupné na: https://print.ispub.com/api/0/ispub­‑article/10839. Go to original source...
    7. Chandra Vemula R, Prasad BCM, Koyalmantham V, et al. Role of Surgery in Intracranial Tuberculomas and Proposal of a Novel Diagnostic Criteria for Diagnosis (Sri Venkateswara Institute of Medical Sciences Criteria). World Neurosurg. 2020;138:e52-e65. doi:10.1016/j.wneu.2020. 01. 179. Go to original source...
    8. Pagnoux C, Généreau T, Lafitte F, et al. Brain tuberculomas. Ann Med Interne (Paris). 2000;151(6): 448-455.
    9. Perez­‑Malagon CD, Barrera­‑Rodriguez R, Lopez­‑Gonzalez MA, et al. Diagnostic and Neurological Overview of Brain Tuberculomas: A Review of Literature. Cureus. 2021;13(12):e20133. doi:10.7759/cureus.20133. Go to original source... Go to PubMed...
    10. Ramachandran R, Muniyandi M, Iyer V, et al. Dilemmas in the diagnosis and treatment of intracranial tuberculomas. J Neurol Sci. 2017;381:256-264. doi:10.1016/j.jns.2017. 08. 3258. Go to original source...
    11. Rock RB, Olin M, Baker CA, et al. Central nervous system tuberculosis: pathogenesis and clinical aspects. Clin Microbiol Rev. 2008;21(2):243-261. doi:10.1128/CMR.00042-07. Go to original source... Go to PubMed...
    12. Roopesh Kumar VR, Gundamaneni SK, Biswas R, et al. Tuberculous cerebellar abscess in immunocompetent individuals. BMJ Case Rep. 2012;6. doi: 10.1136/bcr-2012-006984. Go to original source... Go to PubMed...
    13. Sanei Taheri M, Karimi MA, Haghighatkhah H, et al. Central nervous system tuberculosis: an imaging­‑focused review of a reemerging disease. Radiol Res Pract. 2015;2015:202806. doi:10.1155/2015/202806. Go to original source... Go to PubMed...
    14. ÚZIS. Základní přehled epidemiologické situace ve výskytu tuberkulózy v České republice v roce 2021. Ústav zdravotních informací a statistiky ČR 2021. [Cit. 17. 4. 2023]. Dostupné na: https://www.uzis.cz/res/f/008358/tbc2020-cz.pdf.
    15. Vroblová V, Jankovičová K, Trojáčková­‑Kudlová M. Detekce latentní tuberkulózy QuantiFERON­‑TB Gold test, možnosti a úskalí metody. Prakt Lék. 2009;89(4):204-209.
    16. Wei Z, Zhang X, Wei C, et al. Diagnostic accuracy of in­‑house real­‑time PCR assay for Mycobacterium tuberculosis: a systematic review and meta­‑analysis. BMC Infect, DiS. 2019;19(1):701. doi: 10.1186/s12879-019-4273-z. Go to original source... Go to PubMed...

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