Neurol. pro Praxi, 2002; 2: 82-86

Stimulace nervus vagus v terapii farmakorezistentní epilepsie

MUDr. Milan Brázdil, Ph.D.1, doc. MUDr. Robert Kuba, Ph.D.1, prof. MUDr. Ivan Rektor, CSc.1, prof. MUDr. Zdeněk Novák, CSc.2, MUDr. Jan Chrastina, Ph.D.2
1 I. neurologická klinika LF MU a FN u sv. Anny Brno
2 Neurochirurgická klinika LF MU a FN Brno

Keywords: farmakorezistentní epilepsie, stimulace nervus vagus, kvalita života.

Published: December 31, 2002  Show citation

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Brázdil M, Kuba R, Rektor I, Novák Z, Chrastina J. Stimulace nervus vagus v terapii farmakorezistentní epilepsie. Neurol. praxi. 2002;3(2):82-86.

Dlouhodobá stimulace nervus vagus (VNS) byla zavedena do klinické praxe jako metoda léčby inoperabilních farmakorezistentních epileptických pacientů v roce 1997, v ČR se pravidelně používá od roku 1999. V Centru pro epilepsie v Brně bylo v období I/99-XII/01 metodou VNS léčeno celkem 36 inoperabilních farmakorezistentních epileptiků (19 mužů, 17 žen) ve věku od 17 do 57 let (průměrný věk byl 34,8 roku). Hodnocení efektu VNS terapie bylo prováděno u dvou skupin pacientů: u pacientů s minimálním odstupem 2 roky (N=11) a 1 rok (N=24) po zahájení léčby. Výsledky se v obou skupinách výrazně nelišily: významné zlepšení onemocnění (redukce v počtu záchvatů 50%) bylo dva roky po operaci pozorováno u 55% pacientů (respektive 63% ve skupině minimálně 1 rok po zahájení terapie). Při hodnocení kvality života přímým dotazem pacientů bylo zjištěno zlepšení u 73% (resp. 75%) jedinců. Při analýze vlivu typu epilepsie na efekt VNS byla zjištěna vyšší účinnost stimulace u ložiskových epilepsií v porovnání s víceložiskovými.

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    References

    1. Ben-Menachem E, Manon-Espaillat R, Ristanovic R, et al. Vagus nerve stimulation for treatment of partial seizures: 1. A controlled study of effect of seizures. Epilepsia 1994; 35: 616-626. Go to original source... Go to PubMed...
    2. Ben-Menachem E, Hellstrom K, Waldton C, et al. Evaluation of refractory epilepsy treated with vagus nerve stimulation for up to 5 years. Neurology 1999; 52: 1265-1267. Go to original source... Go to PubMed...
    3. Brázdil M, Chadim P, Daniel P, et al. Effect of vagal nerve stimulation on auditory and visual event-related potentials. Eur J Neurol 2001; 8(5): 457-446. Go to original source... Go to PubMed...
    4. Clark JB, Naritoku DK, Smith DC, et al. Enhanced recognition memory following vagus nerve stimulation in human subjects. Nat Neurosci 1999; 2: 94-98. Go to original source... Go to PubMed...
    5. Cyberonics. VNS Patient Outcome Registry. An update. Vagus Nerve Stimulation European Newsletter 2001; 8: 2-3.
    6. Fisher RS, Handforth A. Reassessment: vagus nerve stimulation for epilepsy: a report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology. Neurology 1999; 53: 666-669. Go to original source... Go to PubMed...
    7. Goodnick PJ, Rush AJ, George MS, et al. Vagus nerve stimulation in depression. Expert Opin Pharmacother 2001; 2(7):1061-1063. Go to original source... Go to PubMed...
    8. Handforth A, DeGiorgio CM, Schacter SC, et al. Vagus nerve stimulation therapy for partial-onset seizures. A randomized active-control trial. Neurology 1998; 51: 48-55. Go to original source... Go to PubMed...
    9. Murphy JV, Hornig G, Schallert G. Left vagal nerve stimulation in children with refractory epilepsy. Preliminary observations. Arch Neurol 1995; 52: 886-889. Go to original source... Go to PubMed...
    10. Ramsay RE, Uthman BM, Augistinsson LE, et al. Vagus nerve stimulation for treatment of partial seizures: 2. Safety, side-effects, and tolerability. Epilepsia 1994; 35: 627-636. Go to original source... Go to PubMed...
    11. Reid SA. Surgical technique for implantation of the neurocybernetic prosthesis. Epilepsia 1990; 31 (Suppl. 2): 38-39. Go to original source... Go to PubMed...
    12. Sackeim HA, Keilp JG, Rush AJ, et al. The effects of vagus nerve stimulation on cognitive performance in patients with treatment resistant depression. Neuropsychiatry Neuropsychol Behav Neurol 2001; 14: 53-62.
    13. Schacter SC, Schmidt D (eds). Vagus nerve stimulation. Martin Dunitz Ltd., London, 2001.
    14. Scherrmann J, Hoppe Ch, Kral T, et al. Vagus nerve stimulation. Clinical experience in a large patient series. J Clin Neurophysiol 2001; 18(5): 408-414. Go to original source... Go to PubMed...
    15. The Vagus Nerve Stimulation Study Group. A randomized controlled trial of chronic nerve stimulation for treatment of medically intractable seizures. Neurology 1995; 45: 224-230. Go to original source... Go to PubMed...
    16. Uthman BM, Wilder BJ, Penry JK, et al. Treatment of epilepsy by stimulation of the vagus nerve. Neurology 1993; 43: 1338-1345. Go to original source... Go to PubMed...
    17. Vonck K, Van Laere K, Dedeurwaerdere S, et al. The mechanism of action vagus nerve stimulation for refractory epilepsy. The current status. J Clin Neurophysiol 2001; 18(5): 394-401. Go to original source... Go to PubMed...

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