Neurol. pro Praxi, 2002; 4: 193-198

Léčba tikových poruch v dětské psychiatrii

prof. MUDr. Ivana Drtílková CSc
Psychiatrická klinika LF MU a FN Brno

Keywords: Tourettův syndrom, tiky, farmakoterapie, léky prvé volby.

Published: December 31, 2002  Show citation

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Drtílková I. Léčba tikových poruch v dětské psychiatrii. Neurol. praxi. 2002;3(4):193-198.

Přesná etiologie Tourettovy poruchy (TP) není jasná, má však pravděpodobně genetický podklad a neurochemickou komponentu. Starší a dosud často předepisovaný haloperidol by vzhledem k výrazným nežádoucí účinkům neměl být považován za preparát první volby. Mezi naše preparáty první volby patří tiaprid, risperidon, klonidin a klonazepam. Pokud tyto preparáty nemají dostatečný efekt, měli bychom doporučit olanzapin, pimozid nebo haloperidol. Nadějný se jeví rovněž potenciální efekt dalších preparátů, jako jsou ziprasidon nebo tetrabenazin. Pokud se spolu s TP vyskytuje obsedantně kompulzivní porucha (OCD), měla by být léčena kombinací selektivních inhibitorů zpětného vychytávání serotoninu (SSRI) s antagonisty dopaminových receptorů. Klonidin je racionální volba, pokud se vyskytuje společně Tourettova a hyperkinetická porucha.

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