Neurol. pro Praxi, 2006; 1: 20-22

Hereditární spastická paraparéza

MUDr. Igor Nestrašil1,2
1 Neurologická ambulance, Masarykův onkologický ústav, Brno
2 I. neurologická klinika LF MU a FN u sv. Anny Brno

Hereditární spastické paraparézy (HSP) jsou heterogenní skupinou dědičných neurodegenerativních onemocnění. Hlavním klinickým příznakem je progredující spasticita dolních končetin. Dědičnost je většinou autozomálně dominantní, avšak byly popsány i rodiny s hereditou autozomálně recesivní či vázanou na X chromozom. Existují formy nekomplikované či čisté, které se projevují pouze spinálním postižením nebo formy komplikované, které jsou asociovány s dalšími příznaky jako je např. ataxie, mentální retardace, demence, extrapyramidové poruchy, zrakové či sluchové poruchy, ichtyóza. HSP bývá též uváděna pod názvem familiární spastická paraparéza nebo Strümpell-(Erb)-Lorrainův syndrom.

Keywords: Klíčová slova: hereditární spastická paraparéza, familiární spastická paraparéza, paraplegie, Strümpell-Lorrain.

Published: January 1, 2006  Show citation

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Nestrašil I. Hereditární spastická paraparéza. Neurol. praxi. 2006;7(1):20-22.
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