Neurol. pro Praxi, 2006; 1: 29-31

Multifokální motorická neuropatie

prof. MUDr. Josef Bednařík, CSc.
Neurologická klinika LF MU a FN u sv. Anny, Brno

Multifokální motorická neuropatie je vzácná autoimunitní neuropatie se subakutním až chronickým průběhem. Klinicky se manifestuje asymetrickou distání slabostí s predilekčním postižením horních končetin. Pro diagnostiku má zásadní význam elektrofyziologický nález perzistujících, multifokálních, částečných bloků motorického vedení, relativně specifickým markerem je i přítomnost autoprotilátek proti GM1 gangliozidům. Léčba intravenózním lidským imunoglobulinem vede k funkčnímu zlepšení u 50–60 % případů nebo alespoň ke stabilizaci stavu; určitý efekt má i cyklofosfamid. Klinický význam této vzácné jednotky tkví v klinické podobnosti s onemocněním motorického neuronu, u kterého neexistuje v současnosti adekvátní účinná léčba.

Keywords: multifokální motorická neuropatie, intravenózní imunoglobulin, onemocnění motorického neuronu

Published: January 1, 2006  Show citation

ACS AIP APA ASA Harvard Chicago Chicago Notes IEEE ISO690 MLA NLM Turabian Vancouver
Bednařík J. Multifokální motorická neuropatie. Neurol. praxi. 2006;7(1):29-31.
Share...
Download citation
  • BibTeX (.bib)
  • Bookends (.ris)
  • EasyBib (.ris)
  • EndNote (.enw)
  • EndNote 8 (.xml)
  • ISI WoS (.isi)
  • Medlars (.medlars)
  • Mendeley (.ris)
  • MODS (.xml)
  • Papers (.ris)
  • RefWorks (.txt)
  • RefManager (.ris)
  • RIS (.ris)
  • MS Word (.xml)
  • Zotero (.ris)
    • Open full article

    References

    1. Bednařík J, Kadaňka Z, Voháňka S. Multifokální motorická neuropatie. Čes a Slov Neurol Neurochir 1999; 62/95: 167-173.
    2. Comi G, Amadio S, Galardi G, Fazio R, Nemni R. Clinical and neurophysiological assessment of immunoglobulin therapy in five patients with multifocal motor neuropathy. J Neurol Neurosurg Psychiatry 1994; 57 (suppl): 35-37. Go to original source... Go to PubMed...
    3. Federico P, Zochodne DW, Hahn AF, Brown WF, Feasby TE. Multifocal motor neuropathy improved by IVIg: randomized, double-blind, placebo-controlled study. Neurology 2000; 55: 1246-1247. Go to original source... Go to PubMed...
    4. Harvey GK, Toyka KV, Zielasek J, Kiefer R, Simonis C, Hartung H-P. Failure of anti-GM IgG or IgM to induce conduction block following intraneural transfer. Muscle Nerve 1995; 18: 388-394. Go to original source... Go to PubMed...
    5. Chad DA, Hammer K, Sargent J. Slow resolution of multifocal weakness and fasciculations: a reversible motor neuron syndrome. Neurology 1986; 36: 1260-1263. Go to original source... Go to PubMed...
    6. Chaudhry V, Corse AM, Cornblath DR, et al. Multifocal motor neuropathy: Response to human immune globulin. Ann Neurol 1993; 33: 237-242. Go to original source... Go to PubMed...
    7. Kaji R, Shibasaki H, Kimura J. Multifocal demyelinating motor neuropathy: Cranial nerve involvement and immunoglobulin therapy. Neurology 1992; 42: 506-509. Go to original source... Go to PubMed...
    8. Lange DJ, Trojaborg W, Latov N, et al. Multifocal motor neuropathy with conduction block: Is it a distinct clinical entity? Neurology 1992; 42: 497-505. Go to original source... Go to PubMed...
    9. Leger JM, Chassande B, Musset L, Meininger V, Bouche P, Baumann N. Intravenous immunoglobulin therapy in multifocal motor neuropathy: a double-blind, placebo-controlled study. Brain 2001; 124: 145-153. Go to original source... Go to PubMed...
    10. Lewis RA, Sumner AJ, Brown MJ, Asbury AK. Multifocal demyelinating neuropathy with persistent conduction block. Neurology 1982; 35: 958-964. Go to original source... Go to PubMed...
    11. Magistris M, Roth G. Motor neuropathy with multifocal persistent conduction blocks. Muscle Nerve 1992; 15: 1056. Go to original source...
    12. Oh SJ, Kim DE, Kuruoglu HR. What is the best diagnostic index of conduction block and temporal dispersion? Muscle Nerve 1994; 17: 489-493. Go to original source... Go to PubMed...
    13. Parry GJ, Clarke S. Multifocal acquired demyelinating neuropathy masquerading as motor neuron disease. Muscle Nerve 1988; 11: 103-107. Go to original source... Go to PubMed...
    14. Pestronk A, Chaudhry V, Feldman EL, et al. Lower motor neuron syndromes defined by patterns of weakness, nerve conduction abnormalities, and high titers of antiglycolipid antibodies. Ann Neurol 1990; 27: 316-326. Go to original source... Go to PubMed...
    15. Pestronk A, Cornblath DR, Ilyas AA, et al. A treatable multifocal motor neuropathy with antibodies to GM1 ganglioside. Ann Neurol 1988; 24: 73-78. Go to original source... Go to PubMed...
    16. Rhee EK, England JD, Sumner AJ: A computer simulation of conduction block: effects produced by actual block versus interphase cancellation. Ann Neurol 1990; 28: 146-156. Go to original source... Go to PubMed...
    17. Roberts M, Willison HJ, Vincent A, Newsom-Davis J. Multifocal motor neuropathy human sera block distal motor nerve conduction in mice. Ann Neurol 1995; 38: 111-118. Go to original source... Go to PubMed...
    18. Roth G, Rohr J, Magistris MR, Oschner F. Motor neuropathy with proximal multifocal persistent block, fasciculations and myokymia. Evolution to tetraplegia. Eur Neurol 1986; 25: 416-423. Go to original source... Go to PubMed...
    19. Thomas PK, Claus D, Jaspert A, et al. Focal upper limb demyelinating neuropathy. Brain 1996; 119: 765-774. Go to original source... Go to PubMed...
    20. Umapathi T, Hughes R. Mycophenolate in treatment resistant inflammatory neuropathies. Eur J Neurol 2002; 9: 683-685. Go to original source... Go to PubMed...
    21. Uncini A, Santoro M, Corbo M, Lugaresi A, Latov N. Conduction abnormalities induced by sera of patients with multifocal motor neuropathy and anti-GM1 antibodies. Muscle Nerve 1993; 16: 610-615. Go to original source... Go to PubMed...

    Return to the content


    Neurology for Practice

    Madam, Sir,
    please be aware that the website on which you intend to enter, not the general public because it contains technical information about medicines, including advertisements relating to medicinal products. This information and communication professionals are solely under §2 of the Act n.40/1995 Coll. Is active persons authorized to prescribe or supply (hereinafter expert).
    Take note that if you are not an expert, you run the risk of danger to their health or the health of other persons, if you the obtained information improperly understood or interpreted, and especially advertising which may be part of this site, or whether you used it for self-diagnosis or medical treatment, whether in relation to each other in person or in relation to others.

    I declare:

    1. that I have met the above instruction
    2. I'm an expert within the meaning of the Act n.40/1995 Coll. the regulation of advertising, as amended, and I am aware of the risks that would be a person other than the expert input to these sites exhibited

    No
    Yes

    If your statement is not true, please be aware
    that brings the risk of danger to their health or the health of others.