Neurol. pro Praxi, 2006; 2: 90-93

Budoucí možnosti genové terapie bolesti

RNDr. Omar Šerý, Ph.D., Prof. William Didden MD., Ph.D.
GHC Research Institute, Houston, TX, U.S.A

Genetická podmíněnost vnímání bolesti je v posledních letech všeobecně přijímaný názor. Polymorfizmy DNA v rámci genů mohou ovlivňovat například míru exprese těchto genů a zasahovat do přenosu nervového signálu či způsobu zpracování nervových signálů. Asociační studie jsou jedním z nástrojů vyhledávání genů, které souvisejí s vnímáním bolesti. Cílem mnohých výzkumů se v dnešní době stává možnost genetického ovlivnění vnímání bolesti. První úspěšné experimenty na potkanech odhalily použitelné cílové geny pro ovlivnění genovou terapií za účelem potlačení bolesti. Je pouze otázkou několika let, kdy se podaří dořešit některé problémy spojené především s nalezením vhodného a bezpečného mechanizmu cíleného přenosu genu do nitra nervových buněk a aplikovat genovou terapii také při léčbě bolesti.

Keywords: Klíčová slova: bolest, genová terapie, gen, polymorfizmus, DNA, léčba.

Published: May 1, 2006  Show citation

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Šerý O, Didden W. Budoucí možnosti genové terapie bolesti. Neurol. praxi. 2006;7(2):90-93.
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