Neurol. pro Praxi, 2007; 2: 80-85

Kombinovaná léčba antiepileptiky u epilepsie: taktika, volba léků, interakce

doc. MUDr. Jiří Hovorka, CSc.1,2, MUDr. Tomáš Nežádal1
1 Neurologické oddělení, neuropsychiatrické a epileptologické centrum, Nemocnice Na Františku s poliklinikou, Praha
2 Neurochirurgická klinika 1. LF UK, Praha

V práci podáváme stručný přehled o kombinované léčbě epilepsie. Uvádíme základní prognostické rysy epilepsie ve vztahu k léčbě, taktiku léčby, předpoklady pro racionální polyterapii a lékové interakce.

Keywords: epilepsie, taktika léčby, přídatná léčba, racionální polyterapie, lékové interakce

Published: July 1, 2007  Show citation

ACS AIP APA ASA Harvard Chicago Chicago Notes IEEE ISO690 MLA NLM Turabian Vancouver
Hovorka J, Nežádal T. Kombinovaná léčba antiepileptiky u epilepsie: taktika, volba léků, interakce. Neurol. praxi. 2007;8(2):80-85.
Share...
Download citation
  • BibTeX (.bib)
  • Bookends (.ris)
  • EasyBib (.ris)
  • EndNote (.enw)
  • EndNote 8 (.xml)
  • ISI WoS (.isi)
  • Medlars (.medlars)
  • Mendeley (.ris)
  • MODS (.xml)
  • Papers (.ris)
  • RefWorks (.txt)
  • RefManager (.ris)
  • RIS (.ris)
  • MS Word (.xml)
  • Zotero (.ris)
    • Open full article

    References

    1. Borowitz KK, Swiader M, Luszki J, et al. Effect of gabapentin on the anticonvulsant activity of antiepileptic drugs against maximal electroshock in mice - an isobolographic analysis. Epilepsia 2002b; 43: 956-963. Go to original source... Go to PubMed...
    2. Brodie MJ. Drug treatment of epilepsy: when does it fail and how to optimize its use? CNS Spectr 2004 Feb; 9 (2): 110-119. Go to original source... Go to PubMed...
    3. Brodie MJ. Medical therapy of epilepsy: when to initiate treatment and when to combine? J Neurol. 2005 Feb; 252 (2): 125-130. Go to original source... Go to PubMed...
    4. Brodie MJ, Kwan P. Staged approach to epilepsy management. Neurology 2002 Apr 23; 58 (8 Suppl 5): 2-8. Go to original source... Go to PubMed...
    5. Bourgeois BFD. Anticonvulsant potency and neurotoxicity of valproate alone and in combination with carbamazepine or phenobarbital. Clin Neuropharmacol 1988a; 11: 348-359. Go to original source... Go to PubMed...
    6. Bourgeois BFD. Combination of valproate and ethosuximide: antiepileptic and neurotoxic interaction. J Pharmacol Exp Ther 1988b; 247: 1128-1132. Go to PubMed...
    7. Deckers CLP, Czuczwar SJ, Hekster YA, et al. Selection of antiepileptic drug polytherapy based on mechanism of action: the evidence reviewed. Epilepsia 2000; 41: 1364-1374. Go to original source... Go to PubMed...
    8. Froscher W, Pisani F, van Rijn CM. The importance of drug interactions in epilepsy therapy. Epilepsia 2002 Apr; 43 (4): 365-385. Go to original source... Go to PubMed...
    9. Hovorka J, Herman E, Nežádal T. Epilepsie a základy antiepileptické léčby II, aspekty psychiatrické. Psychiatrie pro praxi 2004; 4: 13-17.
    10. Hovorka J, Kuba R, Zárubová J. Farmakologická léčba. In: Brázdil M, Marusič P a kol. Epilepsie temporálního laloku. Triton, Praha, 2006: 203-218.
    11. Hovorka J, Nežádal T, Janicadisová M. Klinická charakteristika epilepsie a epileptických záchvatů ve stáří. Čes Ger Rev 2006; 4 (3): 146-156.
    12. Komárek V, Hovorka J. Pseudofarmakorezistence a zásady racionální farmakoterapie. In: Brázdil M, Hadač J, Marusič P et al. Farmakorezistentní epilepsie.Triton, Praha 2004: 171-175.
    13. Kwan P, Brodie MJ. Combination therapy in epilepsy: when and what to use. Drugs 2006; 66 (14): 1817-1829. Go to original source... Go to PubMed...
    14. Kwan P, Brodie MJ. Early identification of refractory epilepsy. N Engl J Med 2000; 342 (5): 314-319. Go to original source... Go to PubMed...
    15. Luszczki JJ, Czuczwar M, Kis J, Krysa J, Pasztelan I, Swiader M, Czuczwar SJ. Interactions of lamotrigine with topiramate and first-generation antiepileptic drugs in the maximal electroshock test in mice: An Isobolographic Analysis. Epilepsia 2003; 44 (8): 1003-1013. Go to original source... Go to PubMed...
    16. Luszczki JJ, Swiader M, Parada-Turska J, et al. Tiagabine synergistically interacts with gabapentin in the electroconvulsive treshold test in mice. Neuropsychopharmacology 2003; 28: 1817-1830. Go to original source... Go to PubMed...
    17. Panayiotopoulos CP. Principles of therapy in epilepsy. In: Panayiotopoulos CP. The Epilepsies: Seizures, Syndromes and Management. Bladom Medical Publishing, Oxfordshire, UK, 2005: 59-82. Go to original source...
    18. Schmidt D. Modern management of epilepsy: Rational polytherapy. Baillieres Clin Neurol 1996; 5: 757-763. Go to PubMed...
    19. Swiader M, Kotowski Gasior M, et al. Interaction of topiramate with conventional antiepileptic drugs in mice. Eur J Pharmacol 2000; 399: 35-41. Go to original source... Go to PubMed...
    20. Schmidt D. Strategies to prevent overtreatment with antiepileptic drugs in patients with epilepsy. Epilepsy Res 2002 Nov; 52 (1): 61-69. Go to original source... Go to PubMed...

    Return to the content


    Neurology for Practice

    Madam, Sir,
    please be aware that the website on which you intend to enter, not the general public because it contains technical information about medicines, including advertisements relating to medicinal products. This information and communication professionals are solely under §2 of the Act n.40/1995 Coll. Is active persons authorized to prescribe or supply (hereinafter expert).
    Take note that if you are not an expert, you run the risk of danger to their health or the health of other persons, if you the obtained information improperly understood or interpreted, and especially advertising which may be part of this site, or whether you used it for self-diagnosis or medical treatment, whether in relation to each other in person or in relation to others.

    I declare:

    1. that I have met the above instruction
    2. I'm an expert within the meaning of the Act n.40/1995 Coll. the regulation of advertising, as amended, and I am aware of the risks that would be a person other than the expert input to these sites exhibited

    No
    Yes

    If your statement is not true, please be aware
    that brings the risk of danger to their health or the health of others.