Neurol. pro Praxi, 2007; 2: 99-101

Roztroušená skleróza: zánět nebo neurodegenerace?

Eva Havrdová
Centrum pro demyelinizační onemocnění Neurologická klinika 1. LF UK a VFN Praha

Představy o patogenezi roztroušené sklerózy (RS) řadu let oscilují mezi větším důrazem na zánětlivé nebo degenerativní změny. Vzájemný vztah zánětu a degenerace není sice definitivně vyřešen, poškození axonů nejen v souvislosti se zánětem se však ukazuje jako nezvratný fakt v časných fázích RS a vede k jednoznačné změně terapeutického postupu u RS. Chybí sice vysoce účinné léky určené k ochraně axonů, ukazuje se však, že léky určené k omezení zánětu mohou mít i neuroprotektivní efekt jako je tomu u glatiramer acetátu.

Keywords: roztroušená skleróza, zánět, degenerativní změny, glatiramer acetát

Published: July 1, 2007  Show citation

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Havrdová E. Roztroušená skleróza: zánět nebo neurodegenerace? Neurol. praxi. 2007;8(2):99-101.
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