Neurol. praxi. 2008;9(4):252-257

Antiepileptika a kojení

MUDr. Ivana Kacířová, doc. MUDr. Milan Grundmann CSc
Ústavklinické farmakologie FN a ZSF OU, Ostrava

V současné době je obecně kojení u žen, které užívají antiepileptika, doporučováno. A to bez ohledu na to, která antiepileptika žena užívá. Dítě je antiepileptikům vystaveno po celou dobu těhotenství transplacentárním přestupem, a to ve vyšších koncentracích. Kojení má jednoznačně větší pozitivní význam než rizika spojená s další expozicí antiepileptikům. Za potenciálně nebezpečné se považuje podávání etosuximidu, fenobarbitalu a primidonu, proto je zde potřebná pečlivá klinická kontrola kojeného dítěte spojená se stanovením hladin těchto antiepileptik v séru matky, dítěte a v mléce. Vyšší plazmatické hladiny u kojených dětí byly popsány také u lamotriginu, kde by mělo být postupováno obdobně.

Keywords: Klíčová slova: kojení, epilepsie, antiepileptika, farmakokinetika.

Published: November 1, 2008  Show citation

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Kacířová I, Grundmann M. Antiepileptika a kojení. Neurol. praxi. 2008;9(4):252-257.
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