Neurol. praxi. 2011;12(1):48-51

Sandifer’s syndrome

MUDr.Miroslava Muchová
Klinika dětské neurologie LF MU a FN Brno

Sandifer’s syndrome is a clinical entity characterised by abnormal movements associated with gastroesophageal reflux, with or without

hiatal hernia. This syndrome occurrs especially in toddlers and infants but it has been rarely reported also among adult patients and

newborns. In the clinical picture various abnormal movements of the body (opisthotonic posturing, head/eye version, torticollis and

other dystonic postures) occur in periods several times per day, mainly after feeding. Sandifer’s syndrome is most commonly mistaken

for epileptic seizures or some form of dystonia. The syndrome is taken for underrecognized.

Keywords: torticollis, nonepileptic seizures, pseudodystonia, gastroesophageal reflux

Published: February 18, 2011  Show citation

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Muchová M. Sandifer’s syndrome. Neurol. praxi. 2011;12(1):48-51.
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    References

    1. Cardi E, Corrado G, Cavaliere M, Capocaccia P, Matrunola M, Rea P, Pacchiarotti C. Delayed gastric emptying in an infant with Sandifer syndrome. Ital J Gastroenterol 1996; 28(9): 518-519.
    2. Cerimagic D, Ivkic G, Bilic E. Neuroanatomical basis of Sandifer's syndrome: a new vagal reflex? Med Hypotheses 2008; 70(5): 957-961. Go to original source... Go to PubMed...
    3. Corrado G, Fossati C, Turchetti A, Pacchiarotti C, Nardelli F, D'Eufemia P. Irritable oesophagus: a new cause of Sandifer's syndrome. Acta Paediatr 2006; 95(11): 1509-1510. Go to original source... Go to PubMed...
    4. Corrado G, Cavaliere M, D'Eufemia P, Pelliccia A, Celli M, Porcelli M, Giardini O, Cardi E. Sandifer's syndrome in a breast-fed infant. Am J Perinatol 2000; 17(3): 147-150. Go to original source... Go to PubMed...
    5. Ghezzi A, Zaffaroni M. Neurological manifestations of gastrointestinal disorders, with particular reference to the differential diagnosis of multiple sclerosis. Neurol Sci 2001; 22(Suppl 2): 117-122. Go to original source... Go to PubMed...
    6. Gorrotxategi P, Reguilon MJ, Arana J. Gastroesophageal reflux in association with the Sandifer syndrome. Eur J Pediatr Surg 1995; 5(4): 203-205. Go to original source... Go to PubMed...
    7. Gordon NS. Sandifer's syndrome: Investigations and treatment. J Pediatr Neurol 2007; 5: 275-278. Go to original source...
    8. Kabakus N, Kurt A. Sandifer Syndrome: a continuing problem of misdiagnosis. Pediatr Int 2006; 48(6): 622-625. Go to original source... Go to PubMed...
    9. Kantor R, Saxton H. Abnormal head and neck movements associated with esophageal perforation and abscess caused by an ingested foreign body. Dysphagia 1987; 2: 50-51. Go to original source... Go to PubMed...
    10. Kinsbourne M. Hiatus hernia with contortions of the neck. Lancet 1964; 1: 1058-1061. Go to original source... Go to PubMed...
    11. Klusáček D. Gastroezofageální reflux v dětském věku. Pediatr. pro Praxi 2001; 1: 36-38.
    12. Klusáček D. Gastroezofageální reflux a refluxní choroba jícnu u dětí. Pediatr. pro Praxi, 2006; 6: 311-316.
    13. Mandel H, Tirosh E, Berant M. Sandifer syndrome reconsidered. Acta Paediatr Scand 1989; 78: 797-799. Go to original source... Go to PubMed...
    14. Murphy WJ, Gellis SS. Torticollis with hiatus hernia in infancy. Sandifer syndrome, Am J Dis Child 1977; 131: 564-565. Go to original source... Go to PubMed...
    15. Olguner M, Akgür FM, Hakgüder G, Aktug T. Gastroesophageal relfux associated with dystonic movements: Sandifer's syndrome. Pediatr Int 1999; 41: 321-322. Go to original source... Go to PubMed...
    16. Puntis JW, Smith HL, Buick RG, Booth IW. Effect of dystonic movements on esophageal peristalsis in Sandifer's syndrome. Arch Dis Child 1989; 64: 1311-1313. Go to original source... Go to PubMed...
    17. Rudolph CD, Mazur LJ, Liptak GS, Baker RD, Boyle JT, Colletti RB, Gerson WT, Werlin SL. Guidelines for Evaluation and Treatment of Gastroesophageal Reflux in Infants and Children: Recommendations of the North American Society for Pediatric Gastroenterology and Nutrition. J Pediatr Gastroenterol Nutr 2001; (Suppl 2/32): 1-31. Go to original source... Go to PubMed...
    18. Shahnawaz M, van der Westhuizen LR, Gledhill RF. Episodic cervical dystonia associated with gastro-oesophageal reflux. A case of adult-onset Sandifer syndrome. Clin Neurol Neurosurg 2001; 103(4): 212-215. Go to original source... Go to PubMed...
    19. Smallpiece CJ, Deverall PB. Sandifer's syndrome: a new cause. Thorax 1982; 37: 634-635. Go to original source... Go to PubMed...
    20. Somjit S, Lee Y, Berkovic SF, Harvey AS. Sandifer syndrome misdiagnosed as refractory partial seizures in an adult. Epileptic Disord 2004; 6(1): 49-50. Go to PubMed...
    21. Sutcliffe J. Torsion spasms and abnormal postures in children with hiatus hernia: Sandifer's syndrome. Prog Pediatr Radiol 1969; 2: 190-197.
    22. Sweetman LL, Ng YT, Kerrigan JF. Gelastic seizures misdiagnosed as gastroesophageal reflux disease. Clin Pediatr 2007; 46(4): 325-328. Go to original source... Go to PubMed...
    23. Vospělová J, Kolek A. Gastroezofageální relfux a nomoc z GER u dětí z pohledu medicíny založené na důkazech. Pediatr. pro Praxi 2003; 3: 154-159.
    24. Werlin SL, D'Souza BJ, Hogan WJ, Dodds WJ, Arndorfer RC. Sandifer syndrome: an unappreciated clinical entity. Dev Med Child Neurol 1980; 22(3): 374-378. Go to original source... Go to PubMed...

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