Neurol. praxi. 2011;12(2):110-113

Sudden unexpected death in epilepsy (SUDEP)

MUDr.Tomáš Procházka
Centrum pro epilepsie, neurologické oddělení, Nemocnice Na Homolce, Praha

Patients with epilepsy have increased mortality and sudden unexpected death (SUDEP) is the most frequent direct epilepsy-related

cause of death. In this review the author summarizes risk factor, proposed mechanisms and potential preventive strategies. Universal

discussion of SUDEP with all patients remains controversial.

Keywords: epilepsy, seizure, mortality, sudden death, SUDEP, ictal, bradycardia

Published: June 1, 2011  Show citation

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Procházka T. Sudden unexpected death in epilepsy (SUDEP). Neurol. praxi. 2011;12(2):110-113.
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    References

    1. Bateman LM, Spitz M, Seyal M. Ictal hypoventilation contributes to cardiac arrhythmia and SUDEP: report on two deaths in video-EEG-monitored patients. Epilepsia 2010; 51: 916-920. Go to original source... Go to PubMed...
    2. Bateman LM, Li CS, Seyal M. Ictal hypoxemia in localization-related epilepsy: analysis of incidence, severity and risk factors. Brain 2008; 131: 3239-3245. Go to original source... Go to PubMed...
    3. Brodie MJ, Holmes GL. Should all patients be told about sudden unexpected death in epilepsy (SUDEP)? Pros and Cons. Epilepsia 2008; 49(Suppl 9): 99-101. Go to original source... Go to PubMed...
    4. Choi H, Sell RL, Lenert L, Muening P, Goodman RR, Gilliam FG, Wong JB. Epilepsy surgery for pharmacoresistant temporal lobe epilepsy: a decision analysis. JAMA 2008; 300: 2497-2505. Go to original source... Go to PubMed...
    5. Gaitatzis A, Johnson AL, Chadwick DW, Shorvon SD, Sander JW. Life expectancy in people with newly diagnosed epilepsy. Brain 2004; 127: 2427-2432. Go to original source... Go to PubMed...
    6. Hitiris N, Mohanraj R, Norrie J, Brodie MJ. Mortality in epilepsy. Epilepsy Behav 2007; 10: 363-376. Go to original source... Go to PubMed...
    7. Hughes JR. A review of sudden unexpected death in epilepsy: prediction of patients at risk. Epilepsy Behav 2009; 14: 280-287. Go to original source... Go to PubMed...
    8. Lhatoo SD, Faulkner HJ, Dembny K, Tippick K, Johnson C, Bird JM. An electroclinical case-control study of sudden unexpected death in epilepsy. Ann Neurol 2010; 68: 787-796. Go to original source... Go to PubMed...
    9. Malow BA, Levy K, Maturen K, Bowes R. Obstructive sleep apnea is common in medically refractory epilepsy patients. Neurology 2000; 55: 1002-1007. Go to original source... Go to PubMed...
    10. Morton B, Richardson A, Duncan S. Sudden unexpected death in epilepsy (SUDEP): don´t ask, don´t tell? J Neurol Neurosurg Psychiatry 2006; 77: 199-202. Go to original source... Go to PubMed...
    11. Nashef L, Hindocha N, Makoff A. Risk factors in sudden death in epilepsy (SUDEP): the quest for mechanisms. Epilepsia 2007; 48: 859-871. Go to original source... Go to PubMed...
    12. Nei M, Hays R. Sudden unexpected death in epilepsy. Curr Neurol Neurosci Rep 2010; 10: 319-326. Go to original source... Go to PubMed...
    13. Nobili L, Proserpio P, Rubboli G, Montano N, Didato G, Tassinari CA. Sudden unexpected death in epilepsy (SUDEP) and sleep. Sleep Med Rev. E-pub, in press.
    14. Scorza FA, Arida RM, Terra VC, Cavalheiro EA. What can be done to reduce the risk of SUDEP? Epilepsy Behav 2010; 18(3): 137-138. Go to original source... Go to PubMed...
    15. So EL. What is known about the mechanisms underlying SUDEP? Epilepsia 2008; 49(Suppl 9): 93-98. Go to original source... Go to PubMed...
    16. So EL, Bainbridge J, Buchhalter JR, Donalty J, Donner EJ, Finucane A, Graves NM, Hirsch LJ, Montouris GD, Temkin NR, Wiebe S, Sierzant TL. Report of the American Epilepsy Society and the Epilepsy Foundation joint task force on sudden unexplained death in epilepsy. Epilepsia 2009; 50(4): 917-922. Go to original source... Go to PubMed...
    17. Schuele SU, Bermeo AC, Alexopoulos AV, Locatelli ER, Burgess RC, Dinner DS, Foldvary-Schaefer N. Video-electrographic and clinical features in patients with ictal asystole. Neurology 2007; 69: 434-441. Go to original source... Go to PubMed...
    18. Rugg-Gunn FJ, Duncan JS, Smith SJ. Cardiac arrhythmias in focal epilepsy: a prospective long-term study. Lancet. 2004; 364: 2212-2219. Go to original source... Go to PubMed...
    19. Sevcencu C, Struijk JJ. Autonomic alterations and cardiac changes in epilepsy. Epilepsia. 2010; 51: 725-737. Go to original source... Go to PubMed...
    20. Seyal M, Bateman LM. Ictal apnea linked to contralateral spread of temporal lobe seizures: intracranial EG recordings in refractory temporal lobe epilepsy. Epilepsia 2009; 50: 2557-2562. Go to original source... Go to PubMed...
    21. Seyal M, Bateman LM, Albertson TE, Lin TC, Li CS. Respiratory changes with seizures in localization-related epilepsy: analysis of periictal hypercapnia and airflow patterns. Epilepsia. 2010; 51: 1359-1364. Go to original source... Go to PubMed...
    22. Surges R, Taggart P, Sander JW, Walker MC. Too long or too short? New insights into abnormal cardiac repolarization in people with chronic epilepsy and its potential role in sudden unexpected death. Epilepsia. 2010; 51: 738-744. Go to original source... Go to PubMed...
    23. Surges R, Thijs RD, Tan HL, Sander JW. Sudden unexpected death in epilepsy: risk factors and potential pathomechanisms. Nat Rev Neurol. 2009; 5: 492-504. Go to original source... Go to PubMed...
    24. Tomson T, Nashef L, Ryvlin P. Sudden unexpected death in epilepsy: current knowledge and future directions. Lancet Neurol. 2008; 7: 1021-1031. Go to original source... Go to PubMed...

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