Neurol. praxi. 2012;13(2):83-86

Drug-induced cognitive impairments

MUDr.Pavel Ressner, Ph.D., MUDr.Petra Bártová, Ph.D.
Kognitivní centrum, Neurologická klinika FN Ostrava

Although somewhat neglected and out of the main focus of recent medical literature, drug-induced cognitive impairments are a serious

issue. The present paper aims to provide an overview of pharmaceuticals with potential risks of inducing cognitive impairments. Pharmaceuticals

with anticholinergic effects and benzodiazepines are associated with the greatest risk. It is always appropriate to consider

possible drug interactions and other risks resulting from the biological and metabolic status of a particular patient. Medications may

interfere with cognition indirectly by affecting metabolism, such as in hypoglycaemia or drug-induced hyponatraemia; by inducing

hypotension and hypoperfusion of the CNS; and by activities that may interfere with synaptic transmission.

Keywords: cognitive impairments, delirium, dementia

Published: April 23, 2012  Show citation

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Ressner P, Bártová P. Drug-induced cognitive impairments. Neurol. praxi. 2012;13(2):83-86.
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    References

    1. Aminoff MJ, Greenberg DA, Simon RP. Clinical Neurology, Sixth Edition Lange Medical Books/MacGrawHill, 2005: 401.
    2. Betteli G. Preoperative evaluation in geriatric surgery: comorbidity, functional status and pharmacological history. Minerva Anestesiol. 2011; 77(6): 637-646. Go to PubMed...
    3. Bowen JD, Larson ER. Drug-induced cognitive impairment-defining the problem and finding solutions. Drugs Aging. 1993; 3: 349-357. Go to original source... Go to PubMed...
    4. Catic AG. Identification and management of in-hospital drug induced delirium in older patients. Drug Aging. 2011; 28(9): 737-748. Go to original source... Go to PubMed...
    5. Edell WS, Tunis SL. Antipsychotic treatment of behavioral and psychological symptoms of dementia in geropsychiatric inpatients. Am J Geriatr Psychiatry. 2001; 9(3): 289-297. Go to original source...
    6. Espino DV, Jules-Bradley ACA, Johnston CL, Mouton CP. Diagnostic approach to the confused elderly patient. Am Fam Physician. 1998; 57: 1358-1366. Go to PubMed...
    7. Flacker JM, Lipsitz LA. Serum anticholinergic activity changes with acute illness in the elderly medical patients. J Gerontol A Biol Sci Med Sci. 1999; 54: M12-M16. Go to original source... Go to PubMed...
    8. Flacker JM, Cummings C, Mach JR, Bettin K, Kiely DK, Wei J. The association of serum anticholinergic activity with delirium in elderly medical patients. Am J Geriatr Psychiatry. 1998; 6: 31-41. Go to original source...
    9. Flaherty JH. Commonly rescribed and over-the-counter medications: causes of confusion. Clin Geriatr Med. 1998; 14: 101-127. Go to original source... Go to PubMed...
    10. Gray SL, Lai KV, Larson EB. Drug induced cognition disorders in the elderly - incidence, prevention and management. Drug. Staf, 1999; 21: 101-122. Go to original source... Go to PubMed...
    11. Inouye SK. The dilemma of delirium: clinical and research controversies regarding diagnosis and evaluation of delirium in hospitalized elderly medical patients. Am J Med. 1994; 97: 278-288. Go to original source... Go to PubMed...
    12. Jirák R, Koukolík F. Demence. Galén, Praha, 2002: 335.
    13. Korneva EA, Kazakova TB, Korneva P. Interleukin-2 Gene Expression in Central Nervous System Cells after Stress and Antigen Application. Neuroimmune Biology. 2008; 6: 353-372. Go to original source...
    14. Langlan SJ, Deary IJ, Hepburn D, Frier BM. Cummulative cognitive impairment following recurrent severe hypoglycemia in adult patients with insulin-treated diabetes mellitus. Diabetologia. 1997; 34: 337-344. Go to original source... Go to PubMed...
    15. Lipowski ZJ. Update on delirium. Psychatr Clon North Am. 1992; 15: 335-346. Go to original source... Go to PubMed...
    16. Moore AR, O´Keefe TO, Drug-induced cognitive impairment in the elderly. Drugs Aging, 1999; 15: 15-28. Go to original source... Go to PubMed...
    17. Parikh SS, Chung F. Postoperative delirium in the elderly. Anest Analg. 1995; 80: 1223-1232. Go to original source...
    18. Ressner P. Farmakologicky indukované poruchy kognititivních funkcí u geriatrických pacientů. In Rektorova I, et al. Kognitiní poruchy a demence. Praha: Triton, 2007; 124(139): 190.
    19. Rimman TA, Evans JM, Krahn LE, Flemming KC. Delirium in the elderly patients: evaluation and management. Mayo Clon Proc. 1995; 70: 989-998. Go to original source... Go to PubMed...
    20. Ropper AH, Samuels MA. Adams and Victor´s Principles of Neurology. 9th ed., MacGrawHill, 2009: 1572.
    21. Rudberg MA, Pompei P, Foreman MD, Ross RE, Cassel CK. The natural history of delirium in older hospitalized patients: a syndrom of heterogenity. Age Aging. 1997; 26: 169-174. Go to original source... Go to PubMed...
    22. Smolík P. Duševní a behaviorální poruchy, Maxdorf, Praha 2002: 506.
    23. Starr JM, Whalley LJ. Drug induced dementia - incidence, management and prevention. Drug Staf. 1994; 11: 310-317. Go to original source... Go to PubMed...
    24. Weinrich S, Sarna L. Delirium in the older person with cancer. Cancer. 1994; 74: 2079-2091. Go to original source... Go to PubMed...

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