Neurol. praxi. 2012;13(4):221-224
Non-paraneoplastic limbic encephalitis with positivity of anti-LGI1 antibodies
- 1 Centrum pro epilepsie Brno, I. neurologická klinika LF MU a FN u sv. Anny v Brně
- 2 Středoevropský technologický institut CEITEC, MU Brno
- 3 Psychiatrická klinika LF MU a FN Brno Bohunice
Limbic encephalitis (LE) is a condition affecting the limbic system that typically presents with memory disorders, with recent memory
being most affected; concurrently, epileptic seizures and psychiatric symptoms can occur. Paraneoplastic limbic encephalitis (PLE) and
non-paraneoplastic limbic encephalitis (NLE) are distinguished. Recently, an association of NLE with anti-LGI1 antibodies has been
described. We report a case of a 45-year-old female patient with LE and positivity of anti-LGI1 antibodies. The differential diagnosis and
treatment of this disease are also discussed.
Keywords: limbic encephalitis, paraneoplastic limbic encephalitis, non-paraneoplastic limbic encephalitis, anti-LGI1 antibodies
Published: July 31, 2012 Show citation
References
- Ances BM, Vitaliani R, Taylor RA, Liebeskind DS, Voloschin A, Houghton DJ, Galetta SL, Dichter M, Alavi A, Rosenfeld MR, Dalmau J. Treatment-responsive limbic encephalitis identified by neuropil antibodies: MRI and PET correlates. Brain. 2005; 128(Pt 8): 1764-1777.
Go to original source... 
Go to PubMed... - Anderson NE, Barber PA. Limbic encephalitis - a review. J Clin Neurosci 2008; 15: 961-971. Go to original source... Go to PubMed...
- Bataller L, Kleopa KA, Wu GF, Rossi JE, Rosenfeld MR, Dalmau J. Autoimmune limbic encephalitis in 39 patients: immunophenotypes and outcomes. J Neurol Neurosurg Psychiatry 2007; 78: 381-385. Go to original source... Go to PubMed...
- Gultekin SH, Rosenfeld MR, Voltz R, Eichen J, Posner JB, Dalmau J. Paraneoplastic limbic encephalitis: neurological symptoms, immunological findings and tumour association in 50 patients. Brain 2000; 123: 1481-1494. Go to original source... Go to PubMed...
- Darnell RB, Posner JB. A new cause of limbic encephalopathy. Brain 2005; 128(Pt 8): 1745-1746. Go to original source... Go to PubMed...
- Irani SR, Buckley C, Vincent A, Cockerell OC, Rudge P, Johnson MR, Smith S. Immunotherapy-responsive seizurelike episodes with potassium channel antibodies. Neurology 2008; 71: 1647-1648. Go to original source... Go to PubMed...
- Irani SR, Alexander S, Waters P, Kleopa KA, Pettingill P, Zuliani L, Peles E, Buckley C, Lang B, Vincent A. Antibodies to Kv1 potassium channel-complex proteins leucine-rich, glioma inactivated 1 protein and contactin-associated protein-2 in limbic encephalitis, Morvan's syndrome and acquired neuromyotonia. Brain 2010; 133: 2734-2748. Go to original source... Go to PubMed...
- Ishiura H, Matsuda S, Higashihara M, Hasegawa M, Hida A, Hanajima R, Yamamoto T, Shimizu J, Dalmau J, Tsuji S. Response of anti-NMDA receptor encephalitis without tumor to immunotherapy including rituximab. Neurology. 2008; 71(23): 1921-1923. Go to original source... Go to PubMed...
- Keime-Guibert F, Graus F, Broët P, Re?é R, Molinuevo JL, Ascaso C, Delattre JY. Clinical outcome of patients with anti-Hu-associated encephalomyelitis after treatment of the tumor. Neurology 1999; 53: 1719-1723. Go to original source... Go to PubMed...
- Kopelman MD. Disorders of memory. Brain 2002; 125: 2152-2190. Go to original source... Go to PubMed...
- Lai M, Huiijbers MG, Lancaster E, et al. Investigation of LG1 as the antigen in limbic encephalitis previously attributed to potasiium channels: a case series. Lancet Neurol 2010; 9: 776-785. Go to original source... Go to PubMed...
- Lawn ND, Westmoreland BF, Kiely MJ, Lennon VA, Vernino S. Clinical, magnetic resonance imaging, and electroencephalographic findings in paraneoplastic limbic encephalitis. Mayo Clin Proc 2003; 78: 1363-1368. Go to original source... Go to PubMed...
- Tüzün E, Dalmau J. Limbic encephalitis and variants: classification, diagnosis and treatment. Neurologist 2007; 13: 261-271. Go to original source... Go to PubMed...
- Vincent A, Bien CG, Irani SR, Waters P. Autoantibodies associated with diseases of the CNS: new developments and future chalenges. Lancet Neurol 2011; 10: 759-772. Go to original source... Go to PubMed...