Neurol. praxi. 2013;14(5):237-239

Deep brain stimulation in the context of neurostimulation treatment of epilepsy

prof.MUDr.Ivan Rektor, CSc., FCMA, FANA
Masarykova univerzita, Centrum pro epilepsie Brno, 1. neurologická klinika LF MU a FN u sv. Anny v Brně

An epileptic seizure is a manifestation of synchronization and spread of abnormally organized rhythmic elec¬trical activity of the brain.

Neurostimulation techniques modulate large-scale distributed neuronal networks, including those involved in epileptic processes.

Vagus nerve stimulation and deep brain stimulation (DBS) of the anterior nucleus of the thalamus (ANT) are routinely utilized in clinical

practice. Both are effective palliative methods in the treatment of pharmacoresistant epilepsy. Further stimulation targets are being

tested; as yet, smaller cohorts of patients with DBS of the subthalamic nucleus, caudate nucleus, centrum medianum of the thalamus

and posterior hypothalamus have been published. Novel methods of stimulation are also being tested, with the most advanced being

the stimulation of epileptic cortex in a closed loop (responsive brain stimulation). Further target structures, optimal methods and their

technical parameters as well as appropriate in¬dications are being searched for and tested.

Keywords: epilepsy, neurostimulation, deep brain stimulation, nucleus anterior thalami

Published: October 15, 2013  Show citation

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Rektor I, FANA. Deep brain stimulation in the context of neurostimulation treatment of epilepsy. Neurol. praxi. 2013;14(5):237-239.
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