Neurol. praxi. 2017;18(2):103-108 | DOI: 10.36290/neu.2017.050
Smoking and multiple sclerosis
- 1Neurologická klinika LF UK a FN Plzeň, 2Neurologická klinika LF UK a FN Hradec Králové
Multiple sclerosis (MS) is a chronic inflammatory disease wherein demyelination and axonal loss occur in the central nervous system
(CNS). MS is a multifactorial disease in which environmental factors can be responsible for triggering an autoimmune response
in genetically susceptible individuals. Environmental factors typically act in combination, while being less selective and having
an effect on the pathogenesis of MS. A complex interplay between individual genetic predisposition and environmental factors
in MS affects both the incidence of MS and its clinical form. The most significant factors include smoking, reduced vitamin D
concentration, reduced UV light exposure, high sodium chloride level, and early Epstein-Barr virus (EBV) infection.
Keywords: multiple sclerosis, smoking, environmental risk factors
Received: October 19, 2017; Accepted: November 12, 2017; Published: May 1, 2017 Show citation
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