Neurol. praxi. 2017;18(3):174-178 | DOI: 10.36290/neu.2019.037

Vitamin D and multiple sclerosis

MUDr. Eva Krasulová, Ph.D.
Neurologická klinika a Centrum klinických neurověd
Univerzita Karlova v Praze, 1. lékařská fakulta a Všeobecná fakultní nemocnice v Praze

Multiple sclerosis (MS) represents severe autoimmune disease of the central nervous system, typically afflicting young people in

productive age. Disease etiology is not exactly known, however negative impact of low vitamin D serum level on disease onset and

progression is undoubted so far. Moreover significant vitamin D deficit is a problem of two thirds of population in our latitude. The

article summarizes up-to-date knowledge about vitamin D and its connection with MS including supplementary recommendation.

Keywords: multiple sclerosis, vitamin D, deficit, supplementation, recommendation

Received: May 15, 2019; Accepted: May 30, 2019; Prepublished online: May 30, 2019; Published: July 1, 2017  Show citation

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Krasulová E. Vitamin D and multiple sclerosis. Neurol. praxi. 2017;18(3):174-178. doi: 10.36290/neu.2019.037.
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    References

    1. Acheson ED, Bachrach CA, Wright FM. Some comments on the relationship of the distribution of multiple sclerosis to latitude, solar radiation, and other variables. Acta Psychiatr Scand Suppl 1960; 35: 132-147. Go to original source... Go to PubMed...
    2. Ascherio A, Munger KL, White R, Köchert K, Simon KC, Polman CH, Freedman MS, Hartung HP, Miller DH, Montalbán X, Edan G, Barkhof F, Pleimes D, Radü EW, Sandbrink R, Kappos L, Pohl C. Vitamin D as an early predictor of multiple sclerosis activity and progression. JAMA Neurol. 2014; 71: 306-314. Go to original source... Go to PubMed...
    3. Backhaus I, Mannocci A, Lemmens PH, La Torre G. Smoking as a risk factor for developing Multiple Sclerosis: a meta-analysis of observational studies. Clin Ter. 2016; 167: 82-92. Go to PubMed...
    4. Caprio M, Infante M, Calanchini M, Mammi C, Fabbri A. Vitamin D: not just the bone. Evidence for beneficial pleiotropic extraskeletal effects. Eat Weight Disord 2017; 22: 27-41. Go to original source...
    5. Compston A, Confavreux C, Lassmann H, McDonald I, Miller D, Noseworthy J, Smith K, Wekerle H. McAlpine's Multiple Sclerosis. Fourth Edition. Elsevier 2006: 110.
    6. Čierny D, Michalik J, Škereňová M, Kantorová E, Sivák Š, Javor J, Kurča E, Dobrota D, Lehotský J. ApaI, BsmI and TaqI VDR gene polymorphisms in association with multiple sclerosis in Slovaks. Neurol Res 2016; 38: 678-684. Go to original source...
    7. Faridar A, Eskandari G, Sahraian MA, Minagar A, Azimi A. Vitamin D and multiple sclerosis: a critical review and recommendations on treatment. Acta Neurol Belg 2012; 112: 327-333. Go to original source... Go to PubMed...
    8. Grossman Z, Hadjipanayis A, Stiris T, Del Torso S, Mercier JC, Valiulis A, Shamir R. Vitamin D in European children-statement from the European Academy of Paediatrics (EAP). Eur J Pediatr. 2017 Apr 12. doi: 10.1007/s00431-017-2903-2. Go to original source...
    9. Hayes DS. Calciferol in tuberculosis. Br Med J 1948; 1: 808. Go to original source...
    10. Holick MF, Binkley NC, Bischoff-Ferrari HA, Gordon CM, Hanley DA, Heaney RP, Murad MH, Weaver CM; Endocrine Society. Evaluation, treatment, and prevention of vitamin D deficiency: an endocrine society clinical practice guideline. J Clin Endocrinol Metab 2011; 96: 1911-1930. Go to original source...
    11. James E, Dobson R, Kuhle J, Baker D, Giovannoni G, Ramagopalan SV. The effect of vitamin D-related interventions on multiple sclerosis relapses: a meta-analysis. Mult Scler 2013; 19: 1571-1579. Go to original source... Go to PubMed...
    12. Krejsek J, Andrýs C, Krčmová I. Imunologie člověka. Hradec Králové: Garamon 2016: 364-365 s.
    13. Laursen JH, S?ndergaard HB, S?rensen PS, Sellebjerg F, Oturai AB. Vitamin D supplementation reduces relapse rate in relapsing-remitting multiple sclerosis patients treated with natalizumab. Mult Scler Relat Disord 2016; 10: 169-173. Go to original source... Go to PubMed...
    14. Lindstedt M. Multiple sclerosis - is research on the wrong track? Med Hypotheses 1991; 34: 69-72. Go to original source... Go to PubMed...
    15. Murray RK, Granner DK, Mayes PA, Rodwell VW. Harperova biochemie. East Norwalk, Connecticut: Appleton & Lange 1993: 545-546 s.
    16. Nielsen NM, Munger KL, Koch-Henriksen N, Hougaard DM, Magyari M, J?rgensen KT, Lundqvist M, Simonsen J, Jess T, Cohen A, Stenager E, Ascherio A. Neonatal vitamin D status and risk of multiple sclerosis: A population-based case-control study. Neurology 2017; 88: 44-51. Go to original source... Go to PubMed...
    17. Płudowski P, Ducki C, Konstantynowicz J, Jaworski M. Vitamin D status in Poland. Pol Arch Med Wewn 2016; 126: 530-539. Go to original source... Go to PubMed...
    18. Stepman HC, Vanderroost A, Van Uytfanghe K, Thienpont LM. Candidate reference measurement procedures for serum 25-hydroxyvitamin D3 and 25-hydroxyvitamin D2 by using isotope-dilution liquid chromatography-tandem mass spectrometry. Clin Chem 2011; 57: 441-448. Go to original source...
    19. Tizaoui K, Kaabachi W, Hamzaoui A, Hamzaoui K. Association between vitamin D receptor polymorphisms and multiple sclerosis: systematic review and meta-analysis of case-control studies. Cell Mol Immunol 2015; 12: 243-252. Go to original source...
    20. Vachová M. Nová epidemiologická data u RS v ČR. Sborník abstrakt - 6. Olomoucké neuroimunologické symposium 2010: 36.
    21. Vinkhuyzen AA, Eyles DW, Burne TH, Blanken LM, Kruithof CJ, Verhulst F, Jaddoe VW, Tiemeier H, McGrath JJ. Prevalence and predictors of vitamin D deficiency based on maternal mid-gestation and neonatal cord bloods: the Generation R Study. J Steroid Biochem Mol Biol 2016; 164: 161-167. Go to original source... Go to PubMed...
    22. Wagner CL, Hollis BW, Kotsa K, Fakhoury H, Karras SN. Vitamin D administration during pregnancy as prevention for pregnancy, neonatal and postnatal complications. Rev Endocr Metab Disord. 2017 Feb 18. doi: 10.1007/s11154-017-9414-3. Go to original source...

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