Neurol. praxi. 2017;18(4):274-278 | DOI: 10.36290/neu.2017.037

Long-term treatment of RLS and PLMS with a positive influence on comorbidities

MUDr. Richard Plný
Neurologická ambulance a spánková poradna Inspamed, Pardubice

Signs of restless legs syndrome (RLS) and periodic limb movement syndrome (PLMS) represent frequent complaints in generaland neurological practice. The prevalence in a broad population is about 10 %. These signs can be overlooked paradoxically fortheir miscellaneous nature (burning, tingling, twitching, pain in legs etc.) and a different intensity. The typical restlessness in thelower limbs alleviated by a motion is mentioned by a part of the patients. Essential is an occurrence of troubles in the eveningmainly before sleep and an improve by the movement. A bed partner testimony of the limbs movement during a sleep can alsobe helpfull in determining the right diagnosis.

Keywords: restless legs syndrome (RLS), periodic limb movement syndrome (PLMS), periodic limb movement index, augmentation
phenomena, generalised anxiety disorder (GAD).

Received: July 23, 2017; Accepted: August 5, 2017; Published: October 1, 2017  Show citation

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Plný R. Long-term treatment of RLS and PLMS with a positive influence on comorbidities. Neurol. praxi. 2017;18(4):274-278. doi: 10.36290/neu.2017.037.
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References

  1. Baldwin D, Ajel K, Masdrakis VG, Nowak M, Rafiq R. Pregabalin for the treatment of generalized anxiety disorder: an update. Neuropsychiatr Dis Treat, 2013; 9: 883-892. Go to original source... Go to PubMed...
  2. Berry RB, Wagner MH. Sleep medicine pearls (third edition). Elsevier 2015: 442-449. Go to original source...
  3. Earley CJ, Silber MH. Restless legs syndrome: Understanding its consequences and the need for better treatment. Sleep Medicine 2010; 11(9): 807-815. Go to original source... Go to PubMed...
  4. Garcia-Borreguero D, Silber MH and collaborators. Guidelines for the first-line treatment of restless legs syndrome/Willis-Ekbom disease, prevention and treatment of dopaminergic augmentation: a combined task force of the IRLSSG, EURLSSG, and the RLS-foundation. Sleep Medicine, 2016; 21: 01-11. Go to original source... Go to PubMed...
  5. Garcia-Borreguero D, Williams A. Dopaminergic augmentation of restless legs syndrome. Sleep Medicine Reviews 2010; 14(5): 339-346. Go to original source... Go to PubMed...
  6. Kemlink D, Vávrová J. Syndrom neklidných nohou. Česká a slovenská neurologie 2011; 74/102(2): 141-149.
  7. Koester K. Pregabalin for use in restless legs syndrome. Kansas university department of pharmacy practice journal, online version, 2017: 1(9).
  8. Narowska D, Bozek M, Krysiak K, Antczak J, Holka-Pokorska J, Jernajczyk W, Wichniak A. Frequent difficulties in the treatment of restless legs syndrome - case report and literature review. Psychiatria Polska 2015; 49(5): 921-930. Go to original source... Go to PubMed...
  9. Ohayon MM, O'Hara R, Vitiello MV. Epidemiology of restless legs syndrome: a synthesis of the literature. Sleep Medicine Reviews 2012, 16: 283-295. Go to original source... Go to PubMed...
  10. Příhodová I, Dostálová S. Spánková medicina v kazuistikách. Mladá fronta 2016; 150: 152.
  11. Silber MH. Sleep-related movement disorders. Continuum, American Academy of Neurology 2013; 19(1): 170-184. Go to original source... Go to PubMed...
  12. SPC. Souhrn údajů o připravku: Lyrica (pregabalin), Pfizer, 11. 5. 2017.
  13. SPC. Souhrn údajů o připravku: Targin (oxycodon/naloxon), Mundipharma Gesellschaft, 20. 9. 2016.
  14. Šonka K. Syndrom neklidných nohou. Jessenius Maxdorf 2006: 11.
  15. Tarsy D, Silber MH. Treatment of restless legs syndrome/Willis-Ekbom disease and periodic limb movement disorder in adults. UpToDate, the online resource for medical evidence-based knowledge, 2017. Dostupný z https://www.uptodate.com/contents/treatment-of-restless-legs-syndrome-willis-ekbom-disease-and-periodic-limb-movement-disorder-in-adults.




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