Neurol. praxi. 2017;18(5):318-321 | DOI: 10.36290/neu.2017.131

T- lymphocytes and B-lymphocytes ant their role in multiple sclerosis

MUDr. Zuzana Matejčíková, Ph.D., prof. MUDr. Jan Mareš, Ph.D.

Neurologická klinika FN a LF UP Olomouc

The multiple sclerosis (MS) is an autoimmune inflammatory demyelinating disease of central nervous system. The inflammatoryprocesses are present especially in early stages of MS. The neurodegenerative processes play role especially in later stages. Thereare characteristic inflammatory infiltrations (particularly in white matter) in MS. In these lesions are activating cells, ie. T-lymphocytes,macrophages and B- lymphocytes. Autoaggressive T and B lymphocytes have various functions in patogenesis of MS andplay any role in the demyelination of nerve fibers and damage of axons. The knowledge of their function is important for understandingthe MS and for development of the drugs modifying disease. In addition to autoimmune processes, the environmentalfactors (geographical, lifestyle, infections) have an important role in MS patogenesis.

Keywords: multiple sclerosis, T lymphocytes, B lymphocytes, autoimmune processes

Received: March 21, 2019; Accepted: April 23, 2019; Prepublished online: April 23, 2019; Published: November 1, 2017  Show citation