Neurol. praxi. 2018;19(6):440-445 | DOI: 10.36290/neu.2018.133

Treatment of peripheral neuropathic pain

MUDr. Jan Lejčko
KARIM, Centrum léčby bolesti, LF UK a FN Plzeň

Neuropathic pain is frequently refractory chronic pain condition representing a significant burden for patiens and healthcaresystem. Epidemiological studies estimate that as many as 7–10 % of adults in the general population have pain with neuropathiccharacteristics. Neuropathic pain differs from nociceptive pain, requires different therapeutic approach and continues to bechallenge. Several evidenced-based recomendations for pharmacological treatments have been published. However, results ofcurrent available pharmacotherapy are unsatisfactory – more than 50 % of patients experience only partial or no relief of theirpain. Hence, in the cases of intractable neuropathic pain interventional therapies such as nerve blocks, radiofrequency and neuromodulatorystrategies has been considered.

Keywords: neuropathic pain, pharmacological treatment, interventional therapy

Published: December 10, 2018  Show citation

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Lejčko J. Treatment of peripheral neuropathic pain. Neurol. praxi. 2018;19(6):440-445. doi: 10.36290/neu.2018.133.
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    References

    1. Bednařík J, Ambler Z, Opavský J, Keller O, Rokyta R, Mazanec R, Lejčko J, Kozák J, Suchý M, Pátá M, Kožený P. Klinický standard pro farmakoterapii neuropatické bolesti. Cesk Slov Neurol 2012; 75/108(1): 93-101.
    2. Bouhassira D, Wilhelm S, Schacht A, Perrot S, Kosek E, Cruccu G, Freynhagen R, Tesfaye S, Lledó A, Choy E, et al. Neuropathic pain phenotyping as a predictor of treatment response in painful diabetic neuropathy: data from the randomized, double blind, COMBO-DN study. Pain. 2014; 155(10): 2171-2110. Go to original source... Go to PubMed...
    3. Cui M, Khanijou S, Rubino J, Aoki KR. Subcutaneous administration of botulinum toxin A reduces formalin-induced pain. Pain 2004; 107(1-2): 125-133. Go to original source... Go to PubMed...
    4. Dworkin RH, O'Connor AB, Kent J, Mackey SC, Raja SN, Stacey BR, Levy RM, Backonja M, Baron R, Harke H, Loeser JD, Treede RD, Turk DC, Wells CD. Interventional management of neuropathic pain: NeuPSIG recommedations. Pain 2013; 154: 2249-2261. Go to original source... Go to PubMed...
    5. Farrar J, Young JP Jr, La Moreaux R, Werth JL, Poole RM. Clinical importance of chronic changes in chronic pain intensity measured on an 11-point numerical pain rating scale. Pain 2001; 94: 149-158. Go to original source... Go to PubMed...
    6. Finnerup NB, Attal N, Haroutounian S, Baron R, Dworkin RH, Gilron I, Haanpaa M, Hansson P, Jensen TS, Kamwerman PR, Lund K, Moore K, Raja SN, Rice ASC, Rowbotam M, Sena E, Siddall P, Smith BH, Wallace M. Pharmacotherapy for neuropathic pain in adults: a systematic review and meta-analysis. Lancet Neurol 2015; 14: 162-173. Go to original source... Go to PubMed...
    7. Gilron I, Jensen TS, Dickenson AH. Combination pharmacotherapy for management of chronic pain: from bench to bedside. Lancet Neurol. 2013; 12(11): 1084-1095. Go to original source... Go to PubMed...
    8. Holbech JV, Jung A, Jonsson T, Wanning M, Bredahl C, Bach FW. Combination treatment of neuropathic pain: Danish expert recommendation basewd on Delphi process. J Pain Res. 2017; 10: 1467-1475. Go to original source... Go to PubMed...
    9. IASP taxonomy, 2012. https://www.iasp-pain.org/Taxonomy
    10. Sills GL. The mechanismus of action of gabapentin and pregabalin. Curr Opin Pharmacol; 2006; 2006 (1): 108-113. Go to original source... Go to PubMed...
    11. Van Hecke O, Austin SK, Khan RA, Smith BH, Torrance N. Neuropathic pain in the general population: a systematic review of epidemiological studies. Pain 2014; 155: 654-662. Go to original source... Go to PubMed...
    12. Watson CP, Vernich L, Chipman M, Reed K. Nortriptyline versus Amitriptyline in postherpetic neuralgia: a randomised controlled trial. Neurology 1998; 51(4): 1166-1171. Go to original source... Go to PubMed...

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