Neurol. praxi. 2020;21(5):384-389

Differential diagnosis of amyotrophic lateral sclerosis

MUDr. Jana Cepková¹, MUDr. Aleš Kopal¹, MUDr. Leoš Ungermann, Ph.D.^2,3, doc. MUDr. Edvard Ehler, CSc.^1,2

¹ Neurologická klinika Pardubické krajské nemocnice, Pardubice

² Fakulta zdravotnických studií Univerzity Pardubice

³ Radiologické oddělení Pardubické krajské nemocnice, Pardubice

Amyotrophic lateral sclerosis is characterized by an impairment of central and peripheral motoneurones. According to contemporary diagnostic criteria (Awaji-shima) on the basis of clinical findings and electrophysiological investigation there si possible to determine a probable or a definite diagnosis of ALS. A clasissical form of ALS with the beginning in the extremities or in the bulbar region with gradual generalization occures most frequently. In a differential diagnosis there is necessary to exclude the whole series of generalized disorders and for various focal forms of ALS also further neurological diseases.

Keywords: motoneurones, pyramidal tract, muscle atrophy, paralysis, EMG findings.

Published: November 11, 2020  Show citation