Neurol. praxi. 2022;23(4):273-277

Malformations of cortical development and their epilepsy surgery

MUDr. Martin Kudr, Ph.D.1, MUDr. Martin Kynčl, Ph.D.2, prof. MUDr. Pavel Kršek, Ph.D.1
1 Klinika dětské neurologie 2. LF UK a FN Motol, Praha
2 Klinika zobrazovacích metod 2. LF UK a FN Motol, Praha

Congenital malformations of cortical development (MCD) are frequent underlying pathology of focal structural epilepsies in children as well as adults. MCDs form a broad group of disorders ranging from well-localized lesions in focal cortical dysplasia (FCD) type II, through lobar and multilobar involvement in FCD types I and II, to extensive malformations affecting one or both hemispheres (hemimegalencephaly, lissencephaly). Pharmacoresistance, which is defined as the failure of two adequately selected anti-seizure drugs at the maximum tolerated doses, is reported in 65% of patients with MCD. For many patients with MCD epilepsy surgery is the only option for successful treatment. This manuscript presents MCDs that can be treated by epilepsy surgery.

Keywords: epilepsy, epilepsy surgery, malformations of cortical development (MCD), focal cortical dysplasias (FCD).

Received: January 16, 2022; Revised: March 25, 2022; Accepted: March 25, 2022; Prepublished online: March 25, 2022; Published: August 30, 2022  Show citation

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Kudr M, Kynčl M, Kršek P. Malformations of cortical development and their epilepsy surgery. Neurol. praxi. 2022;23(4):273-277.
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