Neurol. praxi. 2025;26(4):312-317 | DOI: 10.36290/neu.2025.036

The role of gut dysbiosis in the pathogenesis of neurodegenerative diseases

Petr Roudenský, MSc., MSc.
The University of Sheffield: Neuroscience - Neurodegeneration, Velká Británie

The gut microbiome plays a crucial role in the regulation of the central nervous system through the gut-brain axis, and especially in the last decade, new findings have emerged suggesting a key role of its imbalance - dysbiosis - in the pathogenesis of a number of neurodegenerative diseases, particularly Alzheimer's disease, Parkinson's disease and amyotrophic lateral sclerosis. Underlying mechanisms include increased intestinal permeability, neuroinflammation, microbiota metabolites and disruption of neurotransmitter signalling. Experimental studies suggest that modulation of the gut microbiome, for example through fecal microbial transplantation, may influence the clinical course of these diseases. Further and more rigorous research is needed to elucidate the causality and potential of therapeutic interventions.

Keywords: neurodegeneration, gut microbiome, mikrobiota, dysbiosis, gut-brain axis.

Received: March 5, 2025; Revised: March 5, 2025; Accepted: April 10, 2025; Prepublished online: April 10, 2025; Published: September 29, 2025  Show citation

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Roudenský P. The role of gut dysbiosis in the pathogenesis of neurodegenerative diseases. Neurol. praxi. 2025;26(4):312-317. doi: 10.36290/neu.2025.036.
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