Neurol. praxi. 2017;18(4):261-264 | DOI: 10.36290/neu.2017.096

Immune-mediated necrotizing myopathy

MUDr. Tomáš Kalous1, prof. MUDr. Josef Zámečník, Ph.D.2
1 Neurologická klinika a Centrum klinických neurověd, 1. LF UK a VFN v Praze
1 Neurologie – elektrofyziologické laboratoře, s.r.o., Praha
2 Ústav patologie a molekulární medicíny, 2. LF UK a FN v Motole, Praha

Immune-mediated necrotizing myopathy is considered to be one of the idiopathic inflammatory myopathies. It is characterised byan acute onset of limb girdle weakness with widespread necrosis and regeneration of the myofibrils with minimal inflammatoryinfiltrates. Some patients have myositis-specific antibodies. Combined immunosupression is used for treatment but the responseis often poor with relapses.

Keywords: myopathy, limb girdle weakness, statins, necrosis

Published: October 1, 2017  Show citation

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Kalous T, Zámečník J. Immune-mediated necrotizing myopathy. Neurol. praxi. 2017;18(4):261-264. doi: 10.36290/neu.2017.096.
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