Neurol. praxi. 2021;22(4):315-319 | DOI: 10.36290/neu.2021.052

CGRP inhibitors and gastrointestinal tract

MUDr. Vladimír Kojecký, Ph.D.
Interní oddělení, Krajská nemocnice T. Bati Zlín
Masarykova Univerzita Brno

CGRP antibodies block the vasodilating effect of CGRP and belong to the most potent antimigraine drugs available. The CGRP receptors are present in many tissues, including the gastrointestinal tract. CGRP is thought to be involved in the regulation of gastrointestinal motility, secretion, resorption and blood flow. Blockade of his action may result in a number of adverse effects. For example, a higher incidence of constipation after erenumab (anti-CGRP) has been reported. Hypothetically, these drugs may also impair gastroduodenal ulcerations healing, course of the inflammatory bowel disease or the gastric emptying rate.

Keywords: anti-CGRP, migréna, gastrointestinální trakt.

Received: July 11, 2021; Revised: July 26, 2021; Accepted: August 4, 2021; Prepublished online: August 4, 2021; Published: September 1, 2021  Show citation

ACS AIP APA ASA Harvard Chicago Chicago Notes IEEE ISO690 MLA NLM Turabian Vancouver
Kojecký V. CGRP inhibitors and gastrointestinal tract. Neurol. praxi. 2021;22(4):315-319. doi: 10.36290/neu.2021.052.
Share...
Download citation
  • BibTeX (.bib)
  • Bookends (.ris)
  • EasyBib (.ris)
  • EndNote (.enw)
  • EndNote 8 (.xml)
  • ISI WoS (.isi)
  • Medlars (.medlars)
  • Mendeley (.ris)
  • MODS (.xml)
  • Papers (.ris)
  • RefWorks (.txt)
  • RefManager (.ris)
  • RIS (.ris)
  • MS Word (.xml)
  • Zotero (.ris)
    • Open full article

    References

    1. Ashina M, Goadsby PJ, Reuter U, Silberstein S, Dodick DW, Xue F, Zhang F, Paiva da Silva Lima G, Cheng S, Mikol DD. Long-term efficacy and safety of erenumab in migraine prevention: Results from a 5-year, open-label treatment phase of a randomized clinical trial. Eur J Neurol, 2021; 28: 1716-1725. Go to original source... Go to PubMed...
    2. Engel MA, Khalil M, Siklosi N, Mueller-Tribbensee SM, Neuhuber WL, Neurath MF, Becker C, Reeh PW. Opposite Effects of Substance P and Calcitonin Gene-Related Peptide in Oxazolone Colitis. Digestive and Liver Disease 2012; 44(1): 24-29. Go to original source... Go to PubMed...
    3. Falkenberg K, Bjerg HR, Olesen J Two-Hour CGRP Infusion Causes Gastrointestinal Hyperactivity: Possible Relevance for CGRP Antibody Treatment. Headache: The Journal of Head and Face Pain 2020; 60(5): 929-937. Go to original source... Go to PubMed...
    4. Huang W, Rubinstein J, Prieto AR, Thang LV, Wang DH. Transient Receptor Potential Vanilloid Gene Deletion Exacerbates Inflammation and Atypical Cardiac Remodeling After Myocardial Infarction. Hypertension 2009; 53(2): 243-250. Go to original source... Go to PubMed...
    5. Lenz JH.Calcitonin and CGRP Inhibit Gastrointestinal Transit via Distinct Neuronal Pathways. American Journal of Physiology-Gastrointestinal and Liver Physiology 1988; 254(6): G920-G924. Go to original source... Go to PubMed...
    6. L'Heureux MC, St-Pierre S, Trudel L, Plourde V, Lepage R, Poitras P. Digestive Motor Effects and Vascular Actions of CGRP in Dog Are Expressed by Different Receptor Subtypes. Peptides 2020; 21(3): 425-430. Go to original source... Go to PubMed...
    7. Li FJ, Zou YY, Cui Y, Yin Y, Guo G, Lu FG.Calcitonin Gene-Related Peptide Is a Promising Marker in Ulcerative Colitis. Digestive Diseases and Sciences 2013; 58(3): 686-693. Go to original source... Go to PubMed...
    8. Makowska K, Gonkowski S The Influence of Inflammation and Nerve Damage on the Neurochemical Characterization of Calcitonin Gene-Related Peptide - Like Immunoreactive (CGRP-LI) Neurons in the Enteric Nervous System of the Porcine Descending Colon. International Journal of Molecular Sciences 2018; 19(2): 548. Go to original source... Go to PubMed...
    9. Marathe CS, Rayner CK, Jones KL, Horowitz M. Effects of GLP-1 and Incretin-Based Therapies on Gastrointestinal Motor Function. Experimental Diabetes Research 2011; 2011: 1-10. Go to original source... Go to PubMed...
    10. Mulderry PK, Ghatei MA, Spokes RA, Jones PM, Pierson AM, Hamid QA, Kanse S, Amara SG, Burrin JM, Legon S Differential Expression of Alpha-CGRP and Beta-CGRP by Primary Sensory Neurons and Enteric Autonomic Neurons of the Rat. Neuroscience 1988; 25(1): 195-205. Go to original source... Go to PubMed...
    11. Nilsson C, Hansen TK, Rosenquist C, Hartmann B, Kodra JT, Lau JF, Clausen TR, Raun K, Sams A. Long Acting Analogue of the Calcitonin Gene-Related Peptide Induces Positive Metabolic Effects and Secretion of the Glucagon-like Peptide-1. European Journal of Pharmacology 2016; 773: 24-31. Go to original source... Go to PubMed...
    12. Ornello R, Casalena A, Frattale I, Gabriele A, Affaitati G, Giamberardino MA, Assetta M, Maddestra M, Marzoli F, Viola S, Cerone D, Marini C, Pistoia F, Sacco S. Real-life data on the efficacy and safety of erenumab in the Abruzzo region, central Italy. J Headache Pain 2020; 21, 32. Go to original source... Go to PubMed...
    13. Peskar BM, Wong HC, Walsh JH, Holzer P. A Monoclonal Antibody to Calcitonin Gene-Related Peptide Abolishes Capsaicin-Induced Gastroprotection. European Journal of Pharmacology 1993; 250(1): 201-203. Go to original source... Go to PubMed...
    14. Preibisz J. Calcitonin Gene-Related Peptide and Regulation of Human Cardiovascular Homeostasis. American Journal of Hypertension 1993; 6: 434-450. Go to original source... Go to PubMed...
    15. Rivera-Mancilla E, Villalón CM, MaassenVanDenBrink A CGRP Inhibitors for Migraine Prophylaxis: A Safety Review. Expert Opinion on Drug Safety 2020; 19(10): 1237-1250. Go to original source... Go to PubMed...
    16. Rolston RK, Ghatei MA, Mulderry PK, Bloom SR.. Intravenous Calcitonin Gene-Related Peptide Stimulates Net Water Secretion in Rat Colon in Vivo. Digestive Diseases and Sciences 1989; 34(4): 612-616. Go to original source... Go to PubMed...
    17. Russell FA, King R, Smillie SJ, Kodji X, Brain SD. Calcitonin gene-related peptide: physiology and pathophysiology Calcitonin Gene-Related Peptide: Physiology and Pathophysiology. Physiological Reviews 2014; 94(4): 1099-1142. Go to original source... Go to PubMed...
    18. Toda M, Suzuki T, Hosono K, Kurihara Y, Kurihara H, Hayashi I, Kitasato H, Hoka S, Majima M. Roles of Calcitonin Gene-Related Peptide in Facilitation of Wound Healing and Angiogenesis. Biomedicine & Pharmacotherapy 2008; 62(6): 352-359. Go to original source... Go to PubMed...
    19. Yamasaki H, Mitsuyama K, Yoshioka S, Kuwaki K, Yamauchi R, Fukunaga S, Mori A, Tsuruta O, Torimura T. Leukocyte Apheresis Using a Fiber Filter Suppresses Colonic Injury Through Calcitonin Gene-Related Peptide Induction. Inflammatory Bowel Diseases 2020; 26(5): 709-719. Go to original source... Go to PubMed...
    20. Xiaojing Y, Chen Y, Chen K, Liu M. Efficacy and Safety of CGRP Monoclonal Antibodies for the Prevention of Migraine Compared with Placebo: A Systematic Review and Meta-Analysis 2020; https://www.researchsquare.com/article/rs-39329/v1, accessed June 6, 2021.
    21. Young A. Inhibition of Gastric Emptying. Advances in Pharmacology 2005; 52: 99-121. Go to original source... Go to PubMed...

    Return to the content


    Neurology for Practice

    Madam, Sir,
    please be aware that the website on which you intend to enter, not the general public because it contains technical information about medicines, including advertisements relating to medicinal products. This information and communication professionals are solely under §2 of the Act n.40/1995 Coll. Is active persons authorized to prescribe or supply (hereinafter expert).
    Take note that if you are not an expert, you run the risk of danger to their health or the health of other persons, if you the obtained information improperly understood or interpreted, and especially advertising which may be part of this site, or whether you used it for self-diagnosis or medical treatment, whether in relation to each other in person or in relation to others.

    I declare:

    1. that I have met the above instruction
    2. I'm an expert within the meaning of the Act n.40/1995 Coll. the regulation of advertising, as amended, and I am aware of the risks that would be a person other than the expert input to these sites exhibited

    No
    Yes

    If your statement is not true, please be aware
    that brings the risk of danger to their health or the health of others.