Neurol. praxi. 2014;15(4):182-185

Sleep disturbances and sundowning in Alzheimer’s disease and other dementias

doc. MUDr. Robert Rusina, Ph.D.1,2, doc. MUDr. Iva Holmerová, Ph.D.3,4
1 Neurologická klinika a Centrum klinických neurověd, 1. LF UK a VFN v Praze
2 Neurologické oddělení, Thomayerova nemocnice, Praha

Sleep disturbances and sleep cycle distorsions are relatively common complications of dementia with a negative impact on both the patient’s and his caregiver’s state. Often their occurrence contributes to early institutionalization and may complicate provided care in nursing homes. Sleep disturbances in various neurodegenerative disorders, sleep cycle distorsions and sundowning and their impact on caregivers are discussed. The management is complex, based on non-pharmacological interventions and targeted pharmacotherapy.

Keywords: Alzheimer’s disease, insomnia, sleep cycle, sundowning, non-pharmacological interventions

Published: September 1, 2014  Show citation

ACS AIP APA ASA Harvard Chicago Chicago Notes IEEE ISO690 MLA NLM Turabian Vancouver
Rusina R, Holmerová I. Sleep disturbances and sundowning in Alzheimer’s disease and other dementias. Neurol. praxi. 2014;15(4):182-185.
Share...
Download citation
  • BibTeX (.bib)
  • Bookends (.ris)
  • EasyBib (.ris)
  • EndNote (.enw)
  • EndNote 8 (.xml)
  • ISI WoS (.isi)
  • Medlars (.medlars)
  • Mendeley (.ris)
  • MODS (.xml)
  • Papers (.ris)
  • RefWorks (.txt)
  • RefManager (.ris)
  • RIS (.ris)
  • MS Word (.xml)
  • Zotero (.ris)
    • Open full article

    References

    1. Asada T, Motonaga T, Yamagata Z, Uno M, Takahashi K. Associations between retrospectively recalled napping behavior and later development of Alzheimer's disease: association with APOE genotypes. Sleep 2000; 23: 1-6.
    2. Cheng CY, Tsai CF, Wang SJ, Hsu CY, Fuh JL. Sleep disturbance correlates with white matter hyperintensity in patients with subcortical ischemic vascular dementia. J Geriatr Psychiatry Neurol. 2013; 26: 158-164. Go to original source... Go to PubMed...
    3. David R, Zeitzer J, Friedman L, Noda A, O'Hara R, Robert P, Yesavage JA. Non-pharmacologic management of sleep disturbance in Alzheimer's disease. J Nutr Health Aging 2010; 14: 203-206. Go to original source... Go to PubMed...
    4. Deschenes CL, McCurry SM. Current treatments for sleep disturbances in individuals with dementia. Curr Psychiatry Rep 2009; 11: 20-26. Go to original source... Go to PubMed...
    5. García-Alberca JM, Lara JP, Cruz B, Garrido V, Gris E, Barbancho MA. Sleep disturbances in Alzheimer's disease are associated with neuropsychiatric symptoms and antidementia treatment. J Nerv Ment Dis 2013; 201: 251-257. Go to original source... Go to PubMed...
    6. Hope T, Keene J, Gedling K, Fairburn CG, Jacoby R. Predictors of institutionalization for people with dementia living at home with a carer. Int J Geriatr Psychiatry 1998; 13: 682-690. Go to original source...
    7. Khachiyants N, Trinkle D, Son SJ, Kim KY. Sundown syndrome in persons with dementia: an update. Psychiatry Investig 2011; 8: 275-287. Go to original source... Go to PubMed...
    8. Jiang B, Ding C, Yao G, Yao C, Zhang Y, Ge J, Qiu E, Elia M, Ferri R. Polysomnographic abnormalities in patients with vascular cognitive impairment-no dementia. Sleep Med. 2013; 14: 1071-1075. Go to original source... Go to PubMed...
    9. Ju YE, Lucey BP, Holtzman DM. Sleep and Alzheimer disease pathology-a bidirectional relationship. Nat Rev Neurol. 2014; 10: 115-119. Go to original source... Go to PubMed...
    10. Lim AS, Yu L, Costa MD, Buchman AS, Bennett DA, Leurgans SE, Saper CB. Quantification of the fragmentation of rest-activity patterns in elderly individuals using a state transition analysis. Sleep 2011; 34: 1569-1581. Go to original source... Go to PubMed...
    11. Lim AS, Kowgier M, Yu L, Buchman AS, Bennett DA. Sleep fragmentation and the risk of incident Alzheimer's disease and cognitive decline in older persons. Sleep 2013; 36: 1027-1032. Go to original source... Go to PubMed...
    12. Liu W, Miller BL, Kramer JH, Rankin K, Wyss-Coray C, Gearhart R, Phengrasamy L, Weiner M, Rosen HJ. Behavioral disorders in the frontal and tempoval variants of frontotemporal dementia. Neurology 2004; 62: 742-748. Go to original source... Go to PubMed...
    13. Martin JL, Marler MR, Harker JO, Josephson KR, Alessi CA. A multicomponent nonpharmacological intervention improves aktivity rhythms among nursing home residents with disrupted sleep/wake patterns. J Gerontol Biol Sci Med Sci 2007; 62A: 67-72. Go to original source... Go to PubMed...
    14. Martin JL, Ancoli-Israel S. Sleep disturbances in long-term care. Clin Geriatr Med 2008; 24: 39-50. Go to original source... Go to PubMed...
    15. McCurry SM, Logsdon RG, Vitiello M, Teri L. Treatment of sleep and nighttime in Alzheimer's disease: a behavior management approach. Sleep Med 2004; 5: 373-377. Go to original source... Go to PubMed...
    16. McKeith IG, Dickson DW, Lowe J, Emre M, O'Brien JT, Feldman H, Cummings J, Duda JE, Lippa C, Perry EK, Aarsland D, Arai H, Ballard CG, Boeve B, Burn DJ, Costa D, Del Ser T, Dubois B, Galasko D, Gauthier S, Goetz CG, Gomez-Tortosa E, Halliday G, Hansen LA, Hardy J, Iwatsubo T, Kalaria RN, Kaufer D, Kenny RA, Korczyn A, Kosaka K, Lee VM, Lees A, Litvan I, Londos E, Lopez OL, Minoshima S, Mizuno Y, Molina JA, Mukaetova-Ladinska EB, Pasquier F, Perry RH, Schulz JB, Trojanowski JQ, Yamada M; Consortium on DLB. Diagnosis and management of dementia with Lewy bodies. Third report of DLB consortium. Neurology 2005; 65: 1863-1872. Go to original source... Go to PubMed...
    17. Moran M, Lynch CA, Walsh C, Coen R, Coakley D, Lawlor BA. Sleep disturbance in mild to moderate Alzheimer's disease. Sleep Med 2005; 6: 347-352. Go to original source... Go to PubMed...
    18. Onor ML, Saina M, Trevisiol M, Cristante T, Aguglia E. Clinical experience with risperidone in the treatment of behavioral and psychological symptoms of dementia. Prog Neuropsychopharmacol Biol Psychiatry 2007; 31: 205-209. Go to original source... Go to PubMed...
    19. Rektorová I. Demence s Lewyho tělísky a demence u Parkinsonovy nemoci nejedná se o stejnou diagnózu! Neurol. praxi 2010; 11: 351-354.
    20. Rothman SM, Mattson MP. Sleep disturbances in Alzheimer's and Parkinson's diseases. Neuromolecular Med 2012; 14: 194-204. Go to original source... Go to PubMed...
    21. Schwartz J, Allison MA, Ancoli-Israel S, Hovell MF, Patterson RE, Natarajan L, Marshall SJ, Grant I. Sleep, type 2 diabetes, dyslipidemia, and hypertension in elderly Alzheimer's caregivers. Arch Gerontol Geriatr 2013; 57: 70-77. Go to original source... Go to PubMed...
    22. Sinforiani E, Terzaghi M, Passoti C, Zucchella C, Zambrelli E, Manni R. Hallucinations and sleep-wake cycle in Alzheimer's disease: a questionnaire-based study in 218 patients. Neurol Sci 2007; 28: 96-99. Go to original source... Go to PubMed...
    23. Singer C, Tractenberg RE, Kaye J, Schafer K, Gamst A, Grundman M, Thomas R, Thal LJ; Alzheimer's Disease Cooperative Study.et al. A multicenter, placebo-controlled trial of melatonin for sleep disturbance in Alzheimer's disease. Sleep 2003; 26: 893-901. Go to original source... Go to PubMed...
    24. Stahl SM, Markowitz JF, Gutterman EM, Papadopoulos G. Co-use of donepezil and hypnotics among Alzheimer's disease patients living in the community. J Clin Psychiatry 2003; 64: 466-472. Go to original source... Go to PubMed...
    25. von Känel R, Mausbach BT, Ancoli-Israel S, Dimsdale JE, Mills PJ, Patterson TL, Ziegler MG, Roepke SK, Chattillion EA, Allison M, Grant I. Sleep in spousal Alzheimer caregivers: a longitudinal study with a focus on the effects of major patient transitions on sleep. Sleep 2012; 35: 247-255. Go to original source... Go to PubMed...

    Return to the content


    Neurology for Practice

    Madam, Sir,
    please be aware that the website on which you intend to enter, not the general public because it contains technical information about medicines, including advertisements relating to medicinal products. This information and communication professionals are solely under §2 of the Act n.40/1995 Coll. Is active persons authorized to prescribe or supply (hereinafter expert).
    Take note that if you are not an expert, you run the risk of danger to their health or the health of other persons, if you the obtained information improperly understood or interpreted, and especially advertising which may be part of this site, or whether you used it for self-diagnosis or medical treatment, whether in relation to each other in person or in relation to others.

    I declare:

    1. that I have met the above instruction
    2. I'm an expert within the meaning of the Act n.40/1995 Coll. the regulation of advertising, as amended, and I am aware of the risks that would be a person other than the expert input to these sites exhibited

    No
    Yes

    If your statement is not true, please be aware
    that brings the risk of danger to their health or the health of others.